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Article

Expression and clinical significance of glucose transporter-1 in pancreatic cancer

  • Authors:
    • Kai Lu
    • Jian Yang
    • De‑Chun Li
    • Song‑Bing He
    • Dong‑Ming Zhu
    • Li‑Feng Zhang
    • Xu Zhang
    • Xiao‑Chen Chen
    • Bing Zhang
    • Jian Zhou
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Department of Pathology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200090. P.R. China, Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China
  • Pages: 243-249
    |
    Published online on: May 16, 2016
       https://doi.org/10.3892/ol.2016.4586
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Abstract

Increasing evidence has demonstrated that malignant cells exhibit increased glucose uptake, which facilitates survival and growth in a hypoxic environment. The glucose transporter-1 (GLUT-1) is overexpressed in a variety of malignant tumors. However, the association between GLUT‑1 expression and clinicopathological factors, 18F‑fluorodeoxyglucose uptake and tumor proliferation in pancreatic cancer has not been investigated to date. In the present study, the expression of GLUT‑1 in 53 pancreatic cancer tissues was analyzed, which revealed that GLUT-1 was overexpressed in pancreatic tissue and correlated with poor prognosis and clinicopathological characteristics, including increased tumor size, clinical stage and lymph node metastasis, maximum standardized uptake value (SUVmax) and Ki‑67 expression. The receiver operating characteristic curve analysis indicated that a cut‑off SUVmax value of 4.830 was associated with optimal sensitivity (88%) and specificity (71.4%) for the detection of strong positive GLUT‑1 expression. In addition, as the expression of GLUT‑1 was found to correlate with Ki‑67 expression, GLUT‑1 may exhibit a significant effect on cell proliferation in pancreatic cancer. Overall, these findings indicate that GLUT‑1 may represent a prognostic indicator, and a potential therapeutic target for pancreatic cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Lu K, Yang J, Li DC, He SB, Zhu DM, Zhang LF, Zhang X, Chen XC, Zhang B, Zhou J, Zhou J, et al: Expression and clinical significance of glucose transporter-1 in pancreatic cancer. Oncol Lett 12: 243-249, 2016.
APA
Lu, K., Yang, J., Li, D., He, S., Zhu, D., Zhang, L. ... Zhou, J. (2016). Expression and clinical significance of glucose transporter-1 in pancreatic cancer. Oncology Letters, 12, 243-249. https://doi.org/10.3892/ol.2016.4586
MLA
Lu, K., Yang, J., Li, D., He, S., Zhu, D., Zhang, L., Zhang, X., Chen, X., Zhang, B., Zhou, J."Expression and clinical significance of glucose transporter-1 in pancreatic cancer". Oncology Letters 12.1 (2016): 243-249.
Chicago
Lu, K., Yang, J., Li, D., He, S., Zhu, D., Zhang, L., Zhang, X., Chen, X., Zhang, B., Zhou, J."Expression and clinical significance of glucose transporter-1 in pancreatic cancer". Oncology Letters 12, no. 1 (2016): 243-249. https://doi.org/10.3892/ol.2016.4586
Copy and paste a formatted citation
x
Spandidos Publications style
Lu K, Yang J, Li DC, He SB, Zhu DM, Zhang LF, Zhang X, Chen XC, Zhang B, Zhou J, Zhou J, et al: Expression and clinical significance of glucose transporter-1 in pancreatic cancer. Oncol Lett 12: 243-249, 2016.
APA
Lu, K., Yang, J., Li, D., He, S., Zhu, D., Zhang, L. ... Zhou, J. (2016). Expression and clinical significance of glucose transporter-1 in pancreatic cancer. Oncology Letters, 12, 243-249. https://doi.org/10.3892/ol.2016.4586
MLA
Lu, K., Yang, J., Li, D., He, S., Zhu, D., Zhang, L., Zhang, X., Chen, X., Zhang, B., Zhou, J."Expression and clinical significance of glucose transporter-1 in pancreatic cancer". Oncology Letters 12.1 (2016): 243-249.
Chicago
Lu, K., Yang, J., Li, D., He, S., Zhu, D., Zhang, L., Zhang, X., Chen, X., Zhang, B., Zhou, J."Expression and clinical significance of glucose transporter-1 in pancreatic cancer". Oncology Letters 12, no. 1 (2016): 243-249. https://doi.org/10.3892/ol.2016.4586
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