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Article Open Access

Role of IL-33 expression in oncogenesis and development of human hepatocellular carcinoma

  • Authors:
    • Yan Yang
    • Jun‑Bin Wang
    • Yu‑Mei Li
    • Yu Zhao
    • Rui Wang
    • Qiong Wu
    • Rong‑Sheng Zheng
    • Yu‑Rong Ou
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, P.R. China, Department of Pathology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 429-436
    |
    Published online on: May 25, 2016
       https://doi.org/10.3892/ol.2016.4622
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Abstract

Interleukin-33 (IL-33), a newly-discovered cytokine belonging to the IL-1 family, serves an important role in inflammation. However, it is not clear whether IL‑33 is of clinical significance in hepatocarcinogenesis. The present study was designed to investigate the role of IL‑33 during oncogenesis and development of hepatocellular carcinoma (HCC). IL‑33 protein expression was detected in 76 HCC (including 36 para‑carcinoma), 33 cirrhosis, 30 hepatitis, and 20 normal liver tissues using immunohistochemistry. IL‑33 mRNA expression in carcinoma and para‑carcinoma tissues was evaluated by reverse transcription‑polymerase chain reaction (RT‑PCR). The possible correlation between IL‑33 and clinicopathological parameters of HCC was also analyzed. Significant differences in IL‑33 expression were not observed among normal, hepatic, and cirrhotic tissues (P>0.05), whereas the level of protein positive rate was markedly reduced in HCC tissues (P<0.01). Positive staining of IL‑33 in non‑cancerous liver (NCL) tissues (i.e. normal, hepatitis, and liver cirrhosis) was located predominantly in the nucleus and occasionally in the cytoplasm of hepatocytes; however, the expression in HCC tissues was mostly restricted to the cytoplasm. A significant alteration in protein localization was observed in HCC tissues as compared with NCL tissues (P<0.01). In comparison with HCC tissues, cytoplasmic staining of IL‑33 was increased in para‑carcinoma tissues. RT‑PCR assay further confirmed relatively high mRNA expression levels of IL‑33 in para‑carcinoma tissues. IL‑33 expression was significantly negatively associated with tumor histological grade (r=‑0.279, P=0.015), but not with year, gender, tumor size, clinical stage, HCC with hepatitis and cirrhosis background, lymph node metastasis or intrahepatic vascular embolism (P>0.05). Therefore, the aberrant expression of IL‑33 is associated with oncogenesis and progression of HCC and the cytoplasmic accumulation of the protein may serve a role in hepatocarcinogenesis.
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1 

Marx J: Cancer research. Inflammation and cancer: The link grows stronger. Science. 306:966–968. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Hofseth LJ and Ying L: Identifying and defusing weapons of mass inflammation in carcinogenesis. Biochim Biophys Acta. 1765:74–84. 2006.PubMed/NCBI

3 

Chew V, Tow C, Teo M, et al: Inflammatory tumour microenvironment is associated with superior survival in hepatocellular carcinoma patients. J Hepatol. 52:370–379. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Wong CM and Ng IO: Molecular pathogenesis of hepatocellular carcinoma. Liver Int. 28:160–174. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, McClanahan TK, Zurawski G, Moshrefi M, Qin J, Li X, et al: IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity. 23:479–490. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Milovanovic M, Volarevic V, Radosavljevic G, Jovanovic I, Pejnovic N, Arsenijevic N and Lukic ML: IL-33/ST2 axis in inflammation and immunopathology. Immunol Res. 52:89–99. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Carriere V, Roussel L, Ortega N, Lacorre DA, Americh L, Aguilar L, Bouche G and Girard JP: IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo. Proc Natl Acad Sci USA. 104:282–287. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Chen SF, Nieh S, Jao SW, Wu MZ, Liu CL, Chang YC and Lin YS: The paracrine effect of cancer-associated fibroblast-induced interleukin-33 regulates the invasiveness of head and neck squamous cell carcinoma. J Pathol. 231:180–189. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Jovanovic IP, Pejnovic NN, Radosavljevic GD, Pantic JM, Milovanovic MZ, Arsenijevic NN and Lukic ML: Interleukin-33/ST2 axis promotes breast cancer growth and metastases by facilitating intratumoral accumulation of immunosuppressive and innate lymphoid cells. Int J Cancer. 134:1669–1682. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Sun P, Ben Q, Tu S, Dong W, Qi X and Wu Y: Serum interleukin-33 levels in patients with gastric cancer. Dig Dis Sci. 56:3596–3601. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Hu LA, Fu Y, Zhang DN and Zhang J: Serum IL-33 as a diagnostic and prognostic marker in non-small cell lung cancer. Asian Pac J Cancer Prev. 14:2563–2566. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Liu J, Shen JX, Hu JL, Huang WH and Zhang GJ: Significance of interleukin-33 and its related cytokines in patients with breast cancers. Front Immunol. 5:1412014. View Article : Google Scholar : PubMed/NCBI

13 

Bonilla WV, Fröhlich A, Senn K, Kallert S, Fernandez M, Johnson S, Kreutzfeldt M, Hegazy AN, Schrick C, Fallon PG, et al: The alarmin interleukin-33 drives protective antiviral CD8+ T cell responses. Science. 335:984–989. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Arshad MI, Rauch M, L'Helgoualc'h A, Julia V, Leite-de-Moraes MC, Lucas-Clerc C, Piquet-Pellorce C and Samson M: NKT cells are required to induce high IL-33 expression in hepatocytes during ConA-induced acute hepatitis. Eur J Immunol. 41:2341–2348. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Wang J, Cai Y, Ji H, Feng J, Ayana DA, Niu J and Jiang Y: Serum IL-33 levels are associated with liver damage in patients with chronic hepatitis B. J Interferon Cytokine Res. 32:248–253. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Marvie P, Lisbonne M, L'Helgoualc'h A, Rauch M, Turlin B, Preisser L, Bourd-Boittin K, Théret N, Gascan H, Piquet-Pellorce C and Samson M: Interleukin-33 overexpression is associated with liver fibrosis in mice and humans. J Cell Mol Med. 14:1726–1739. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Zhang P, Liu XK, Chu Z, Ye JC, Li KL, Zhuang WL, Yang DJ and Jiang YF: Detection of interleukin-33 in serum and carcinoma tissue from patients with hepatocellular carcinoma and its clinical implications. J Int Med Res. 40:1654–1661. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Bergis D, Kassis V, Ranglack A, Koeberle V, Piiper A, Kronenberger B, Zeuzem S, Waidmann O and Radeke HH: High serum levels of the interleukin-33 receptor soluble ST2 as a negative prognostic factor in hepatocellular carcinoma. Transl Oncol. 6:311–318. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Sakai N, Van Sweringen HL, Quillin RC, Schuster R, Blanchard J, Burns JM, Tevar AD, Edwards MJ and Lentsch AB: Interleukin-33 is hepatoprotective during liver ischemia/reperfusion in mice. Hepatology. 56:1468–1478. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Edmondson HA and Steiner PE: Primary carcinoma of the liver: A study of 100 cases among 48,900 necropsies. Cancer. 7:462–503. 1954. View Article : Google Scholar : PubMed/NCBI

21 

Zheng R, Wang J, Wu Q, Wang Z, Ou Y, Ma L, Wang M, Wang J and Yang Y: Expression of ALDH1 and TGFβ2 in benign and malignant breast tumors and their prognostic implications. Int J Clin Exp Pathol. 7:4173–4183. 2014.PubMed/NCBI

22 

He XD, Wang Y, Wu Q, Wang HX, Chen ZD, Zheng RS, Wang ZS, Wang JB and Yang Y: Xuebijing protects rats from sepsis challenged with acinetobacter baumannii by promoting annexin A1 expression and inhibiting proinflammatory cytokines secretion. Evid Based Complement Alternat Med. 2013:8049402013. View Article : Google Scholar : PubMed/NCBI

23 

Goncalves CK, Fregnani ER, Leon JE, Silva-Sousa YT and Perez DE: Immunohistochemical expression of p63, epidermal growth factor receptor (EGFR) and notch-1 in radicular cysts, dentigerous cysts and keratocystic odontogenic tumors. Braz Dent J. 23:337–343. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Yang Y, Qin SK, Wu Q, Wang ZS, Zheng RS, Tong XH, Liu H, Tao L and He XD: Connexin-dependent gap junction enhancement is involved in the synergistic effect of sorafenib and all-trans retinoic acid on HCC growth inhibition. Oncol Rep. 31:540–550. 2014.PubMed/NCBI

25 

Zhang DY and Friedman SL: Fibrosis-dependent mechanisms of hepatocarcinogenesis. Hepatology. 56:769–775. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Baekkevold ES, Roussigné M, Yamanaka T, Johansen FE, Jahnsen FL, Amalric F, Brandtzaeg P, Erard M, Haraldsen G and Girard JP: Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules. Am J Pathol. 163:69–79. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Hayakawa H, Hayakawa M, Kume A and Tominaga S: Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation. J Biol Chem. 282:26369–26380. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Arend WP, Palmer G and Gabay C: IL-1, IL-18, and IL-33 families of cytokines. Immunol Rev. 223:20–38. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Lüthi AU, Cullen SP, McNeela EA, Duriez PJ, Afonina IS, Sheridan C, Brumatti G, Taylor RC, Kersse K, Vandenabeele P, et al: Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases. Immunity. 31:84–98. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Cayrol C and Girard JP: The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1. Proc Natl Acad Sci USA. 106:9021–9026. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Kunes P, Holubcová Z, Kolácková M and Krejsek J: The counter-regulation of atherogenesis: A role for interleukin-33. Acta Medica (Hradec Kralove). 53:125–129. 2010.PubMed/NCBI

32 

Miller AM: Role of IL-33 in inflammation and disease. J Inflamm (Lond). 8:222011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang Y, Wang JB, Li YM, Zhao Y, Wang R, Wu Q, Zheng RS and Ou YR: Role of IL-33 expression in oncogenesis and development of human hepatocellular carcinoma. Oncol Lett 12: 429-436, 2016.
APA
Yang, Y., Wang, J., Li, Y., Zhao, Y., Wang, R., Wu, Q. ... Ou, Y. (2016). Role of IL-33 expression in oncogenesis and development of human hepatocellular carcinoma. Oncology Letters, 12, 429-436. https://doi.org/10.3892/ol.2016.4622
MLA
Yang, Y., Wang, J., Li, Y., Zhao, Y., Wang, R., Wu, Q., Zheng, R., Ou, Y."Role of IL-33 expression in oncogenesis and development of human hepatocellular carcinoma". Oncology Letters 12.1 (2016): 429-436.
Chicago
Yang, Y., Wang, J., Li, Y., Zhao, Y., Wang, R., Wu, Q., Zheng, R., Ou, Y."Role of IL-33 expression in oncogenesis and development of human hepatocellular carcinoma". Oncology Letters 12, no. 1 (2016): 429-436. https://doi.org/10.3892/ol.2016.4622
Copy and paste a formatted citation
x
Spandidos Publications style
Yang Y, Wang JB, Li YM, Zhao Y, Wang R, Wu Q, Zheng RS and Ou YR: Role of IL-33 expression in oncogenesis and development of human hepatocellular carcinoma. Oncol Lett 12: 429-436, 2016.
APA
Yang, Y., Wang, J., Li, Y., Zhao, Y., Wang, R., Wu, Q. ... Ou, Y. (2016). Role of IL-33 expression in oncogenesis and development of human hepatocellular carcinoma. Oncology Letters, 12, 429-436. https://doi.org/10.3892/ol.2016.4622
MLA
Yang, Y., Wang, J., Li, Y., Zhao, Y., Wang, R., Wu, Q., Zheng, R., Ou, Y."Role of IL-33 expression in oncogenesis and development of human hepatocellular carcinoma". Oncology Letters 12.1 (2016): 429-436.
Chicago
Yang, Y., Wang, J., Li, Y., Zhao, Y., Wang, R., Wu, Q., Zheng, R., Ou, Y."Role of IL-33 expression in oncogenesis and development of human hepatocellular carcinoma". Oncology Letters 12, no. 1 (2016): 429-436. https://doi.org/10.3892/ol.2016.4622
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