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Article Open Access

Evaluation of the ‘Hedgehog’ signaling pathways in squamous and basal cell carcinomas of the eyelids and conjunctiva

  • Authors:
    • Ali Riza Cenk Celebi
    • Hayyam Kiratli
    • Figen Soylemezoglu
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, Acibadem University School of Medicine, 34303 Istanbul, Turkey, Department of Ophthalmology, Hacettepe University School of Medicine, 06100 Ankara, Turkey, Department of Pathology, Hacettepe University School of Medicine, 06100 Ankara, Turkey
    Copyright: © Celebi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 467-472
    |
    Published online on: May 25, 2016
       https://doi.org/10.3892/ol.2016.4625
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Abstract

The purpose of the present study was to assess the role of hedgehog signaling pathway in the carcinogenesis of eyelid skin and conjunctival epithelial malignant tumors. The study was conducted on specimens from 41 patients with cutaneous eyelid basal cell carcinoma, 22 with bulbar conjunctival squamous cell carcinoma, 12 with bulbar conjunctival intraepithelial neoplasia. Major molecules of Hedgehog signaling pathway (Sonic Hedgehog [Shh] and Patched-1 [Ptch-1] and Glioma-associated oncogene [Gli-1]) were evaluated in paraffin‑embedded tissue specimens using immunohistochemical staining. For each specimen, the percentage (<10%, 10‑50%, >50%) and the intensity of the immunohistochemical staining (graded from 0 to 3) were calculated and the scores obtained by multiplication of two values were analyzed using the Kruskall‑Wallis test. Shh and Ptch‑1 expression levels were statistically significantly lower in the basal cell carcinoma group compared with the squamous cell carcinoma group (P=0.043 for Shh; P=0.030 for Ptch-1). In the conjunctival squamous cell carcinoma group, the Ptch‑1 score was 0 in ~25% of specimens and the Gli‑1 score was ≤2 in ~45% of cases. In the conjunctival intraepithelial neoplasia group, the Ptch‑1 score was ≥2 in 66% of specimens, the Gli‑1 score was ≤2 in ~92% of cases. Ptch‑1 mutations contribute to the development of cutaneous eyelid basal cell carcinoma. The present study provides evidence that alterations in hedgehog signaling pathways may lead to transformation of the conjunctival intraepithelial neoplasia into invasive squamous cell carcinoma.
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1 

Rosner M: Section 2 eyelid tumors basal cell carcinoma. Clinical Ophthalmic Oncology. Singh AD, Damato BE, Murphree AL and Perry JD: Saunders, Elsevier. (Philadelphia, USA). 76–80. 2007. View Article : Google Scholar

2 

Margo CE and Waltz K: Basal cell carcinoma of the eyelid and periocular skin. Surv Ophthalmol. 38:169–192. 1993. View Article : Google Scholar : PubMed/NCBI

3 

Allali J, D'Hermies F and Renard G: Basal cell carcinomas of the eyelids. Ophthalmologica. 219:57–71. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Green A: Changing patterns in incidence of non-melanoma skin cancer. Epithelial Cell Biol. 1:47–51. 1992. View Article : Google Scholar : PubMed/NCBI

5 

Donaldson MJ, Sullivan TJ, Whitehead KJ and Williamson RM: Squamous cell carcinoma of the eyelids. Br J Ophthalmol. 86:1161–1165. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Lee GA and Hirst LW: Ocular surface squamous neoplasia. Surv Ophthalmol. 39:429–450. 1995. View Article : Google Scholar : PubMed/NCBI

7 

Tumbar T, Guasch G, Greco V, Blanpain C, Lowry WE, Rendl M and Fuchs E: Defining the epithelial stem cell niche in skin. Science. 303:359–363. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Molofsky AV, Pardal R and Morrison SJ: Diverse mechanisms regulate stem cell self-renewal. Curr Opin Cell Biol1. 6:700–707. 2004. View Article : Google Scholar

9 

Evangelista M, Tian H and de Sauvage FJ: The hedgehog signaling pathway in cancer. Clin Cancer Res. 12:5924–5928. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Guerrero I and Ruizi Altaba A: Development: Longing for ligand: Hedgehog, patched, and cell death. Science. 301:774–776. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Toftgård R: Hedgehog signalling in cancer. Cell Mol Life Sci. 57:1720–1731. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Hutchin ME, Kariapper MS, Grachtchouk M, Wang A, Wei L, Cummings D, Liu J, Michael LE, Glick A and Dlugosz AA: Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: Conditional skin tumorigenesis recapitulates the hair growth cycle. Genes Dev. 19:214–223. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Owens DM and Watt FM: Contribution of stem cells and differentiated cells to epidermal tumors. Nat Rev Cancer. 3:444–451. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Ruiz A, Altaba I, Stecca B and Sánchez P: Hedgehog-Gli signaling in brain tumors: Stem cells and paradevelopmental programs in cancer. Cancer Lett. 204:145–157. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Wolter M, Reifenberger J, Sommer C, Ruzicka T and Reifenberger G: Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. Cancer Res. 57:2581–2585. 1997.PubMed/NCBI

16 

Chidambaram A, Goldstein AM, Gailani MR, Gerrard B, Bale SJ, DiGiovanna JJ, Bale AE and Dean M: Mutations in the human homologue of the Drosophila patched gene in Caucasian and African-American nevoid basal cell carcinoma syndrome patients. Cancer Res. 56:4599–4601. 1996.PubMed/NCBI

17 

Tostar U, Malm CJ, Meis-Kindblom JM, Toftgård R and Undén AB: Deregulation of the hedgehog signalling pathway: A possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development. J Pathol. 208:17–25. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Xie J, Johnson RL, Zhang X, Bare JW, Waldman FM, Cogen PH, Menon AG, Warren RS, Chen LC, Scott MP and Epstein EH Jr: Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors. Cancer Res. 57:2369–2372. 1997.PubMed/NCBI

19 

Ruizi Altaba A: Gli proteins encode context-dependent positive and negative functions: Implications for development and disease. Development. 126:3205–3216. 1999.PubMed/NCBI

20 

Dahmane N, Lee J, Robins P, Heller P and Ruizi Altaba A: Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours. Nature. 389:876–881. 1997. View Article : Google Scholar : PubMed/NCBI

21 

Mori Y, Okumura T, Tsunoda S, Sakai Y and Shimada Y: Gli-1 expression is associated with lymph node metastasis and tumor progression in esophageal squamous cell carcinoma. Oncology. 70:378–389. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Schneider S, Thurnher D, Kloimstein P, Leitner V, Petzelbauer P, Pammer J, Brunner M and Erovic BM: Expression of the Sonic hedgehog pathway in squamous cell carcinoma of the skin and the mucosa of the head and neck. Head Neck. 33:244–250. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Wicking C and McGlinn E: The role of hedgehog signalling in tumorigenesis. Cancer Lett. 173:1–7. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Tojo M, Mori T, Kiyosawa H, Honma Y, Tanno Y, Kanazawa KY, Yokoya S, Kaneko F and Wanaka A: Expression of sonic hedgehog signal transducers, patched and smoothened, in human basal cell carcinoma. Pathol Int. 49:687–694. 1999. View Article : Google Scholar : PubMed/NCBI

25 

Kim MY, Park HJ, Baek SC, Byun DG and Houh D: Mutations of the p53 and PTCH gene in basal cell carcinomas: UV mutation signature and strand bias. J Dermatol Sci. 29:1–9. 2002. View Article : Google Scholar : PubMed/NCBI

26 

De Gruijl FR, Van Kranen HJ and Mullenders LH: UV-induces DNA damage, repair, mutations and oncogenic pathways in skin cancer. J Photochem Photobiol B. 63:19–27. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Holikova Z, Massi D, Lotti T and Hercogová J: Insight into the pathogenesis of sporadic basal cell carcinoma. Int J Dermatol. 43:865–869. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Green J, Leigh IM, Poulsom R and Quinn AG: Basal cell carcinoma development is associated with induction of the expression of the transcription factor Gli-1. Br J Dermatol. 139:911–915. 1998. View Article : Google Scholar : PubMed/NCBI

29 

Lupi O: Correlations between the sonic hedgehog pathway and basal cell carcinoma. Int J Dermatol. 46:1113–1117. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Xuan YH, Li GL, Jiang HY and Lin ZH: Relationship between hedgehog signaling pathway molecules and HPV16 infection in uterine cervical cancers. Zhonghua Bing Li Xue Za Zhi. 38:178–182. 2009.(In Chinese). PubMed/NCBI

31 

Xuan YH, Jung HS, Choi YL, Shin YK, Kim HJ, Kim KH, Kim WJ, Lee YJ and Kim SH: Enhanced expression of hedgehog signaling molecules in squamous cell carcinoma of uterine cervix and its precursor lesions. Mod Pathol. 19:1139–1147. 2006.PubMed/NCBI

32 

Cavicchioli Buim ME, Gurgel CA, Gonçalves Ramos EA, Lourenço SV and Soares FA: Activation of sonic hedgehog signaling in oral squamous cell carcinomas: A preliminary study. Hum Pathol. 42:1484–1490. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Nishimaki H, Kasai K, Kozaki Ki, Takeo T, Ikeda H, Saga S, Nitta M and Itoh G: A role of activated Sonic hedgehog signaling for the cellular proliferation of oral squamous cell carcinoma cell line. Biochem Biophys Res Commun. 314:313–320. 2004. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Celebi AR, Kiratli H and Soylemezoglu F: Evaluation of the ‘Hedgehog’ signaling pathways in squamous and basal cell carcinomas of the eyelids and conjunctiva. Oncol Lett 12: 467-472, 2016.
APA
Celebi, A.R., Kiratli, H., & Soylemezoglu, F. (2016). Evaluation of the ‘Hedgehog’ signaling pathways in squamous and basal cell carcinomas of the eyelids and conjunctiva. Oncology Letters, 12, 467-472. https://doi.org/10.3892/ol.2016.4625
MLA
Celebi, A. R., Kiratli, H., Soylemezoglu, F."Evaluation of the ‘Hedgehog’ signaling pathways in squamous and basal cell carcinomas of the eyelids and conjunctiva". Oncology Letters 12.1 (2016): 467-472.
Chicago
Celebi, A. R., Kiratli, H., Soylemezoglu, F."Evaluation of the ‘Hedgehog’ signaling pathways in squamous and basal cell carcinomas of the eyelids and conjunctiva". Oncology Letters 12, no. 1 (2016): 467-472. https://doi.org/10.3892/ol.2016.4625
Copy and paste a formatted citation
x
Spandidos Publications style
Celebi AR, Kiratli H and Soylemezoglu F: Evaluation of the ‘Hedgehog’ signaling pathways in squamous and basal cell carcinomas of the eyelids and conjunctiva. Oncol Lett 12: 467-472, 2016.
APA
Celebi, A.R., Kiratli, H., & Soylemezoglu, F. (2016). Evaluation of the ‘Hedgehog’ signaling pathways in squamous and basal cell carcinomas of the eyelids and conjunctiva. Oncology Letters, 12, 467-472. https://doi.org/10.3892/ol.2016.4625
MLA
Celebi, A. R., Kiratli, H., Soylemezoglu, F."Evaluation of the ‘Hedgehog’ signaling pathways in squamous and basal cell carcinomas of the eyelids and conjunctiva". Oncology Letters 12.1 (2016): 467-472.
Chicago
Celebi, A. R., Kiratli, H., Soylemezoglu, F."Evaluation of the ‘Hedgehog’ signaling pathways in squamous and basal cell carcinomas of the eyelids and conjunctiva". Oncology Letters 12, no. 1 (2016): 467-472. https://doi.org/10.3892/ol.2016.4625
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