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Article Open Access

Concomitant essential thrombocythemia with JAK2 V617F mutation in a patient with chronic myeloid leukemia with major molecular response with imatinib and long-term follow-up

  • Authors:
    • Katia Borgia Barbosa Pagnano
    • Márcia Torresan Delamain
    • Mariana Munari Magnus
    • José Vassallo
    • Carmino Antonio De Souza
    • Daiane De Almeida
    • Irene Lorand‑Metze
  • View Affiliations / Copyright

    Affiliations: Hematology and Hemotherapy Center, University of Campinas, Campinas, São Paulo, SP 13083‑868, Brazil, Department of Pathological Anatomy, University of Campinas, Campinas, São Paulo, SP 13083‑868, Brazil
    Copyright: © Pagnano et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 485-487
    |
    Published online on: May 26, 2016
       https://doi.org/10.3892/ol.2016.4631
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Abstract

The association of chronic myeloid leukemia (CML) with other myeloproliferative neoplasms (MPNs), in particular with the V617F mutation in the Janus kinase 2 (JAK2) gene, is very uncommon, and there are only a few cases reported in the literature. In the present study, the case of a 73‑year‑old man with CML and persistent thrombocytosis, is reported. The patient achieved a complete cytogenetic response and major molecular response (MR) with imatinib. The patient presented JAK2 V617F mutation, and bone marrow morphology was consistent with essential thrombocythemia. The patient was treated with imatinib and hydroxyurea to control the platelet count, and maintains complete MR with imatinib upon 10 years of follow‑up. Although rare, the association of breakpoint cluster region‑Abelson rearrangement and JAK2 V617F mutation should be investigated in patients with MPN, since both genetic anomalies may be present at diagnosis or may emerge during treatment, and require different therapeutic approaches.
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Copy and paste a formatted citation
Spandidos Publications style
Pagnano KB, Delamain MT, Magnus MM, Vassallo J, De Souza CA, De Almeida D and Lorand‑Metze I: Concomitant essential thrombocythemia with JAK2 V617F mutation in a patient with chronic myeloid leukemia with major molecular response with imatinib and long-term follow-up. Oncol Lett 12: 485-487, 2016.
APA
Pagnano, K.B., Delamain, M.T., Magnus, M.M., Vassallo, J., De Souza, C.A., De Almeida, D., & Lorand‑Metze, I. (2016). Concomitant essential thrombocythemia with JAK2 V617F mutation in a patient with chronic myeloid leukemia with major molecular response with imatinib and long-term follow-up. Oncology Letters, 12, 485-487. https://doi.org/10.3892/ol.2016.4631
MLA
Pagnano, K. B., Delamain, M. T., Magnus, M. M., Vassallo, J., De Souza, C. A., De Almeida, D., Lorand‑Metze, I."Concomitant essential thrombocythemia with JAK2 V617F mutation in a patient with chronic myeloid leukemia with major molecular response with imatinib and long-term follow-up". Oncology Letters 12.1 (2016): 485-487.
Chicago
Pagnano, K. B., Delamain, M. T., Magnus, M. M., Vassallo, J., De Souza, C. A., De Almeida, D., Lorand‑Metze, I."Concomitant essential thrombocythemia with JAK2 V617F mutation in a patient with chronic myeloid leukemia with major molecular response with imatinib and long-term follow-up". Oncology Letters 12, no. 1 (2016): 485-487. https://doi.org/10.3892/ol.2016.4631
Copy and paste a formatted citation
x
Spandidos Publications style
Pagnano KB, Delamain MT, Magnus MM, Vassallo J, De Souza CA, De Almeida D and Lorand‑Metze I: Concomitant essential thrombocythemia with JAK2 V617F mutation in a patient with chronic myeloid leukemia with major molecular response with imatinib and long-term follow-up. Oncol Lett 12: 485-487, 2016.
APA
Pagnano, K.B., Delamain, M.T., Magnus, M.M., Vassallo, J., De Souza, C.A., De Almeida, D., & Lorand‑Metze, I. (2016). Concomitant essential thrombocythemia with JAK2 V617F mutation in a patient with chronic myeloid leukemia with major molecular response with imatinib and long-term follow-up. Oncology Letters, 12, 485-487. https://doi.org/10.3892/ol.2016.4631
MLA
Pagnano, K. B., Delamain, M. T., Magnus, M. M., Vassallo, J., De Souza, C. A., De Almeida, D., Lorand‑Metze, I."Concomitant essential thrombocythemia with JAK2 V617F mutation in a patient with chronic myeloid leukemia with major molecular response with imatinib and long-term follow-up". Oncology Letters 12.1 (2016): 485-487.
Chicago
Pagnano, K. B., Delamain, M. T., Magnus, M. M., Vassallo, J., De Souza, C. A., De Almeida, D., Lorand‑Metze, I."Concomitant essential thrombocythemia with JAK2 V617F mutation in a patient with chronic myeloid leukemia with major molecular response with imatinib and long-term follow-up". Oncology Letters 12, no. 1 (2016): 485-487. https://doi.org/10.3892/ol.2016.4631
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