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Article

Use of negative pressure wound therapy as an adjunct to the treatment of extremity soft-tissue sarcoma with ulceration or impending ulceration

  • Authors:
    • Yu Chen
    • Song‑Feng Xu
    • Ming Xu
    • Xiu‑Chun Yu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedic Surgery, General Hospital of Jinan Military Commanding Region, Jinan, Shandong 250031, P.R. China
  • Pages: 757-763
    |
    Published online on: June 1, 2016
       https://doi.org/10.3892/ol.2016.4654
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Abstract

Major wound complications of the extremities, following wide tumor resection and reconstruction for soft‑tissue sarcomas (STSs), remain a challenge for limb‑sparing surgery. Furthermore, STSs with ulceration or impending ulceration predispose patients to an increased risk of post‑operative infection. The present study was conducted to assess the efficacy of negative pressure wound therapy (NPWT) in preventing wound complications associated with surgical treatment of STSs with ulceration or impending ulceration, in patients treated between February 2012 and January 2013. A total of 5 patients, with a mean age of 48 years (range, 24‑68 years), were enrolled in the present study. The diagnoses consisted of undifferentiated pleomorphic sarcoma (n=2), leiomyosarcoma (n=1), synovial sarcoma (n=1) and epithelioid sarcoma (n=1). According to American Joint Committee on Cancer criteria, 3 cases were stage III tumors, and the remaining 2 cases were of stages ⅡA and ⅡB, respectively. A total of 3 patients exhibited ulceration at diagnosis, and the remaining patients demonstrated impending ulceration. The mean wound area following wide resection of the tumor was 73 cm2 (range, 45‑110 cm2). A continuous suction mode, with pressures measuring ‑200 to ‑300 mmHg, was used for 7‑10 days on the soft‑tissue defects as preparation for wound closure. Soft‑tissue reconstruction included muscle flaps (n=2) and skin grafts (n=5). No major wound complications occurred. Post‑operative functional and cosmetic outcomes were acceptable. A single patient demonstrated local recurrence 12 months after surgery and re‑excision of the tumor was performed. All patients remained alive at the conclusion of follow‑up, with a mean follow‑up time of 26 months (range, 12‑36 months). The present study demonstrated that NPWT is effective and safe when used as an adjunct to wound closure following resection of extremity STS with ulceration/impending ulceration.
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1 

Rosenberg AE: WHO classification of soft tissue and bone, fourth edition: Summary and commentary. Curr Opin Oncol. 25:571–573. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Kneisl JS, Coleman MM and Raut CP: Outcomes in the management of adult soft tissue sarcomas. J Surg Oncol. 110:527–538. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Gronchi A, Colombo C and Raut CP: Surgical management of localized soft tissue tumors. Cancer. 120:2638–2648. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Trovik CS, Bauer HC, Alvegård TA, Anderson H, Blomqvist C, Berlin O, Gustafson P, Saeter G and Wallöe A: Surgical margins, local recurrence and metastasis in soft tissue sarcomas: 559 surgically-treated patients from the Scandinavian Sarcoma Group Register. Eur J Cancer. 36:710–716. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Williard WC, Collin C, Casper ES, Hajdu SI and Brennan MF: The changing role of amputation for soft tissue sarcoma of the extremity in adults. Surg Gynecol Obstet. 175:389–396. 1992.PubMed/NCBI

6 

Talbot SG, Athanasian EA, Cordeiro PG and Mehrara BJ: Soft tissue reconstruction following tumor resection in the hand. Hand Clin. 20(vi): 181–202. 2004. View Article : Google Scholar

7 

Baldini EH, Lapidus MR, Wang Q, Manola J, Orgill DP, Pomahac B, Marcus KJ, Bertagnolli MM, Devlin PM, George S, et al: Predictors for major wound complications following preoperative radiotherapy and surgery for soft-tissue sarcoma of the extremities and trunk: Importance of tumor proximity to skin surface. Ann Surg Oncol. 20:1494–1499. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Jeong HS, Lee BH, Lee HK, Kim HS, Moon MS and Suh IS: Negative pressure wound therapy of chronically infected wounds using 1% acetic Acid irrigation. Arch Plast Surg. 42:59–67. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Orgill DP, Manders EK, Sumpio BE, Lee RC, Attinger CE, Gurtner GC and Ehrlich HP: The mechanisms of action of vacuum assisted closure: More to learn. Surgery. 146:40–51. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Karaaslan F, Erdem Ş and Mermerkaya MU: Wound management with vacuum-assisted closure in postoperative infections after surgery for spinal stenosis. Int Med Case Rep J. 8:7–11. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Wu CC, Chew KY, Chen CC and Kuo YR: Antimicrobial-impregnated dressing combined with negative-pressure wound therapy increases split-thickness skin graft engraftment: A simple effective technique. Adv Skin Wound Care. 28:21–27. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Putnis S, Khan WS and Wong JM: Negative pressure wound therapy - a review of its uses in orthopaedic trauma. Open Orthop J. 8:142–147. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Lahat G, Tuvin D, Wei C, Anaya DA, Bekele BN, Lazar AJ, Pisters PW, Lev D and Pollock RE: New perspectives for staging and prognosis in soft tissue sarcoma. Ann Surg Oncol. 15:2739–2748. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Gronchi A, Verderio P, De Paoli A, Ferraro A, Tendero O, Majò J, Martin J, Comandone A, Grignani G, Pizzamiglio S, et al: Quality of surgery and neoadjuvant combined therapy in the ISG-GEIS trial on soft tissue sarcomas of limbs and trunk wall. Ann Oncol. 24:817–823. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Barwick WJ, Goldberg JA, Scully SP and Harrelson JM: Vascularized tissue transfer for closure of irradiated wounds after soft tissue sarcoma resection. Ann Surg. 216:591–595. 1992. View Article : Google Scholar : PubMed/NCBI

16 

Boyce DE and Shokrollahi K: Reconstructive surgery. BMJ. 332:710–712. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Turner AJ and Parkhouse N: Revisiting the reconstructive ladder. Plast Reconstr Surg. 118:267–268. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Lohman RF, Nabawi AS, Reece GP, Pollock RE and Evans GR: Soft tissue sarcoma of the upper extremity: A 5-year experience at two institutions emphasizing the role of soft tissue flap reconstruction. Cancer. 94:2256–2264. 2002. View Article : Google Scholar : PubMed/NCBI

19 

Geller DS, Hornicek FJ, Mankin HJ and Raskin KA: Soft tissue sarcoma resection volume associated with wound-healing complications. Clin Orthop Relat Res. 459:182–185. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Li J, Topaz M, Tan H, Li Y, Li W, Xun W, Yuan Y, Chen S and Li X: Treatment of infected soft tissue blast injury in swine by regulated negative pressure wound therapy. Ann Surg. 257:335–344. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Blum ML, Esser M, Richardson M, Paul E and Rosenfeldt FL: Negative pressure wound therapy reduces deep infection rate in open tibial fractures. J Orthop Trauma. 26:499–505. 2012. View Article : Google Scholar : PubMed/NCBI

22 

de Laat EH, van den Boogaard MH, Spauwen PH, van Kuppevelt DH, van Goor H and Schoonhoven L: Faster wound healing with topical negative pressure therapy in difficult-to-heal wounds: A prospective randomized controlled trial. Ann Plast Surg. 67:626–631. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Kim BS, Choi WJ, Baek MK, Kim YS and Lee JW: Limb salvage in severe diabetic foot infection. Foot Ankle Int. 32:31–37. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Scherer SS, Pietramaggiori G, Mathews JC, Prsa MJ, Huang S and Orgill DP: The mechanism of action of the vacuum-assisted closure device. Plast Reconstr Surg. 122:786–797. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Oh BH, Lee SH, Nam KA, Lee HB and Chung KY: Comparison of negative pressure wound therapy and secondary intention healing after excision of acral lentiginous melanoma on the foot. Br J Dermatol. 168:333–338. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Katz MS, Finck CM, Schwartz MZ, Moront ML, Prasad R, Timmapuri SJ and Arthur LG: Vacuum-assisted closure in the treatment of extensive lymphangiomas in children. J Pediatr Surg. 47:367–370. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Ferguson PC, Kulidjian AA, Jones KB, Deheshi BM and Wunder JS: Peripheral nerve considerations in the management of extremity soft tissue sarcomas. Recent Results Cancer Res. 179:243–256. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Mahendra A, Gortzak Y, Ferguson PC, Deheshi BM, Lindsay TF and Wunder JS: Management of vascular involvement in extremity soft tissue sarcoma. Recent Results Cancer Res. 179:285–299. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Lee SK and Wolfe SW: Nerve transfers for the upper extremity: New horizons in nerve reconstruction. J Am Acad Orthop Surg. 20:506–517. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Wong JC and Abraham JA: Upper extremity considerations for oncologic surgery. Orthop Clin North Am. 45:541–564. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Borgquist O, Ingemansson R and Malmsjö M: Individualizing the use of negative pressure wound therapy for optimal wound healing: A focused review of the literature. Ostomy Wound Manage. 57:44–54. 2011.PubMed/NCBI

32 

Younan G, Ogawa R, Ramirez M, Helm D, Dastouri P and Orgill DP: Analysis of nerve and neuropeptide patterns in vacuum-assisted closure-treated diabetic murine wounds. Plast Reconstr Surg. 126:87–96. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Huang C, Leavitt T, Bayer LR and Orgill DP: Effect of negative pressure wound therapy on wound healing. Curr Probl Surg. 51:301–331. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen Y, Xu SF, Xu M and Yu XC: Use of negative pressure wound therapy as an adjunct to the treatment of extremity soft-tissue sarcoma with ulceration or impending ulceration. Oncol Lett 12: 757-763, 2016.
APA
Chen, Y., Xu, S., Xu, M., & Yu, X. (2016). Use of negative pressure wound therapy as an adjunct to the treatment of extremity soft-tissue sarcoma with ulceration or impending ulceration. Oncology Letters, 12, 757-763. https://doi.org/10.3892/ol.2016.4654
MLA
Chen, Y., Xu, S., Xu, M., Yu, X."Use of negative pressure wound therapy as an adjunct to the treatment of extremity soft-tissue sarcoma with ulceration or impending ulceration". Oncology Letters 12.1 (2016): 757-763.
Chicago
Chen, Y., Xu, S., Xu, M., Yu, X."Use of negative pressure wound therapy as an adjunct to the treatment of extremity soft-tissue sarcoma with ulceration or impending ulceration". Oncology Letters 12, no. 1 (2016): 757-763. https://doi.org/10.3892/ol.2016.4654
Copy and paste a formatted citation
x
Spandidos Publications style
Chen Y, Xu SF, Xu M and Yu XC: Use of negative pressure wound therapy as an adjunct to the treatment of extremity soft-tissue sarcoma with ulceration or impending ulceration. Oncol Lett 12: 757-763, 2016.
APA
Chen, Y., Xu, S., Xu, M., & Yu, X. (2016). Use of negative pressure wound therapy as an adjunct to the treatment of extremity soft-tissue sarcoma with ulceration or impending ulceration. Oncology Letters, 12, 757-763. https://doi.org/10.3892/ol.2016.4654
MLA
Chen, Y., Xu, S., Xu, M., Yu, X."Use of negative pressure wound therapy as an adjunct to the treatment of extremity soft-tissue sarcoma with ulceration or impending ulceration". Oncology Letters 12.1 (2016): 757-763.
Chicago
Chen, Y., Xu, S., Xu, M., Yu, X."Use of negative pressure wound therapy as an adjunct to the treatment of extremity soft-tissue sarcoma with ulceration or impending ulceration". Oncology Letters 12, no. 1 (2016): 757-763. https://doi.org/10.3892/ol.2016.4654
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