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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Hypermethylation reduces the expression of PNPLA7 in hepatocellular carcinoma

  • Authors:
    • Xiaojiao Zhang
    • Jun Zhang
    • Rui Wang
    • Shicheng Guo
    • Huilu Zhang
    • Yanyun Ma
    • Qingmei Liu
    • Haiyan Chu
    • Xianghong Xu
    • Yitong Zhang
    • Dongqin Yang
    • Jiucun Wang
    • Jie Liu
  • View Affiliations / Copyright

    Affiliations: Department of Digestive Diseases, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China, Ministry of Education (MOE) Key Laboratory of Contemporary Anthropology, State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200433, P.R. China
  • Pages: 670-674
    |
    Published online on: June 1, 2016
       https://doi.org/10.3892/ol.2016.4660
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Abstract

Liver cancer has a high morbidity and mortality rate, and is one of the most common types of cancer in men. PNPLA7 is a member of the patatin‑like phospholipase domain‑containing protein family which is involved in triglyceride hydrolysis, energy metabolism and lipid droplet metabolism. The liver is the most important energy metabolism organ; whether PNPLA7 is deregulated in liver cancer has not been previously reported. In the present study, reverse transcription‑quantitative polymerase chain reaction and subsequent methylation analysis provided evidence that PNPLA7 is down‑regulated in hepatocellular carcinoma (HCC) cell lines and tissue samples, via the mechanism of transcriptional silencing by promoter hypermethylation. These results may provide novel insights for HCC diagnosis.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Leong TY and Leong AS: Epidemiology and carcinogenesis of hepatocellular carcinoma. HPB (Oxford). 7:5–15. 2005. View Article : Google Scholar : PubMed/NCBI

3 

El-Serag HB and Rudolph KL: Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis. Gastroenterology. 132:2557–2576. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Buendia MA and Neuveut C: Hepatocellular carcinoma. Cold Spring Harb Perspect Med. 5:a0214442015. View Article : Google Scholar : PubMed/NCBI

5 

Lemmer ER, Friedman SL and Llovet JM: Molecular diagnosis of chronic liver disease and hepatocellular carcinoma: The potential of gene expression profiling. Semin Liver Dis. 26:373–384. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Matter MS, Decaens T, Andersen JB and Thorgeirsson SS: Targeting the mTOR pathway in hepatocellular carcinoma: Current state and future trends. J Hepatol. 60:855–865. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Easwaran H, Tsai HC and Baylin SB: Cancer epigenetics: Tumor heterogeneity, plasticity of stem-like states and drug resistance. Mol Cell. 54:716–727. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Ma L, Chua MS, Andrisani O and So S: Epigenetics in hepatocellular carcinoma: An update and future therapy perspectives. World J Gastroenterol. 20:333–345. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Rydel TJ, Williams JM, Krieger E, Moshiri F, Stallings WC, Brown SM, Pershing JC, Purcell JP and Alibhai MF: The crystal structure, mutagenesis, and activity studies reveal that patatin is a lipid acyl hydrolase with a Ser-Asp catalytic dyad. Biochemistry. 42:6696–6708. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Wilson PA, Gardner SD, Lambie NM, Commans SA and Crowther DJ: Characterization of the human patatin-like phospholipase family. J Lipid Res. 47:1940–1949. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Finn RD, Bateman A, Clements J, Coggill P, Eberhardt RY, Eddy SR, Heger A, Hetherington K, Holm L, Mistry J, et al: Pfam: The protein families database. Nucleic Acids Res. 42(Database Issue): D222–D230. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Winrow CJ, Hemming ML, Allen DM, Quistad GB, Casida JE and Barlow C: Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity. Nat Genet. 33:477–485. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Kienesberger PC, Lass A, Preiss-Landl K, Wolinski H, Kohlwein SD, Zimmermann R and Zechner R: Identification of an insulin-regulated lysophospholipase with homology to neuropathy target esterase. J Biol Chem. 283:5908–5917. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Herman JG and Baylin SB: Methylation-specific PCR. Curr Protoc Hum Genet Chapter. 10:Unit 10.6. 2001. View Article : Google Scholar

15 

Kienesberger PC, Oberer M, Lass A and Zechner R: Mammalian patatin domain containing proteins: A family with diverse lipolytic activities involved in multiple biological functions. J Lipid Res. 50(Suppl): S63–S68. 2009.PubMed/NCBI

16 

Chang PA, Long DX, Sun Q, Wang Q, Bu YQ and Wu YJ: Identification and characterization of a splice variant of the catalytic domain of mouse NTE-related esterase. Gene. 417:43–50. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Richardson RJ, Hein ND, Wijeyesakere SJ, Fink JK and Makhaeva GF: Neuropathy target esterase (NTE): Overview and future. Chem Biol Interact. 203:238–244. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Chang PA, Chen YY, Long DX, Qin WZ and Mou XL: Degradation of mouse NTE-related esterase by macroautophagy and the proteasome. Mol Biol Rep. 39:7125–7131. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Kotronen A, Johansson LE, Johansson LM, Roos C, Westerbacka J, Hamsten A, Bergholm R, Arkkila P, Arola J, Kiviluoto T, et al: A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans. Diabetologia. 52:1056–1060. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Sookoian S, Castaño GO, Burgueño AL, Gianotti TF, Rosselli MS and Pirola CJ: A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity. J Lipid Res. 50:2111–2116. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Valenti L, Al-Serri A, Daly AK, Galmozzi E, Rametta R, Dongiovanni P, Nobili V, Mozzi E, Roviaro G, Vanni E, et al: Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease. Hepatology. 51:1209–1217. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Vrieze SI, Malone SM, Pankratz N, Vaidyanathan U, Miller MB, Kang HM, McGue M, Abecasis G and Iacono WG: Genetic associations of nonsynonymous exonic variants with psychophysiological endophenotypes. Psychophysiology. 51:1300–1308. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Jones PA and Laird PW: Cancer epigenetics comes of age. Nat Genet. 21:163–167. 1999. View Article : Google Scholar : PubMed/NCBI

24 

Lopez-Serra P and Esteller M: DNA methylation-associated silencing of tumor-suppressor microRNAs in cancer. Oncogene. 31:1609–1622. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang X, Zhang J, Wang R, Guo S, Zhang H, Ma Y, Liu Q, Chu H, Xu X, Zhang Y, Zhang Y, et al: Hypermethylation reduces the expression of PNPLA7 in hepatocellular carcinoma. Oncol Lett 12: 670-674, 2016.
APA
Zhang, X., Zhang, J., Wang, R., Guo, S., Zhang, H., Ma, Y. ... Liu, J. (2016). Hypermethylation reduces the expression of PNPLA7 in hepatocellular carcinoma. Oncology Letters, 12, 670-674. https://doi.org/10.3892/ol.2016.4660
MLA
Zhang, X., Zhang, J., Wang, R., Guo, S., Zhang, H., Ma, Y., Liu, Q., Chu, H., Xu, X., Zhang, Y., Yang, D., Wang, J., Liu, J."Hypermethylation reduces the expression of PNPLA7 in hepatocellular carcinoma". Oncology Letters 12.1 (2016): 670-674.
Chicago
Zhang, X., Zhang, J., Wang, R., Guo, S., Zhang, H., Ma, Y., Liu, Q., Chu, H., Xu, X., Zhang, Y., Yang, D., Wang, J., Liu, J."Hypermethylation reduces the expression of PNPLA7 in hepatocellular carcinoma". Oncology Letters 12, no. 1 (2016): 670-674. https://doi.org/10.3892/ol.2016.4660
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang X, Zhang J, Wang R, Guo S, Zhang H, Ma Y, Liu Q, Chu H, Xu X, Zhang Y, Zhang Y, et al: Hypermethylation reduces the expression of PNPLA7 in hepatocellular carcinoma. Oncol Lett 12: 670-674, 2016.
APA
Zhang, X., Zhang, J., Wang, R., Guo, S., Zhang, H., Ma, Y. ... Liu, J. (2016). Hypermethylation reduces the expression of PNPLA7 in hepatocellular carcinoma. Oncology Letters, 12, 670-674. https://doi.org/10.3892/ol.2016.4660
MLA
Zhang, X., Zhang, J., Wang, R., Guo, S., Zhang, H., Ma, Y., Liu, Q., Chu, H., Xu, X., Zhang, Y., Yang, D., Wang, J., Liu, J."Hypermethylation reduces the expression of PNPLA7 in hepatocellular carcinoma". Oncology Letters 12.1 (2016): 670-674.
Chicago
Zhang, X., Zhang, J., Wang, R., Guo, S., Zhang, H., Ma, Y., Liu, Q., Chu, H., Xu, X., Zhang, Y., Yang, D., Wang, J., Liu, J."Hypermethylation reduces the expression of PNPLA7 in hepatocellular carcinoma". Oncology Letters 12, no. 1 (2016): 670-674. https://doi.org/10.3892/ol.2016.4660
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