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Review

Role of periostin in esophageal, gastric and colon cancer (Review)

  • Authors:
    • Tadeusz Moniuszko
    • Andrzej Wincewicz
    • Mariusz Koda
    • Izabela Domysławska
    • Stanisław Sulkowski
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Diagnostics and Bronchofiberoscopy, Medical University of Białystok, Białystok, 15‑269 Podlaskie, Poland, Department of Anatomy, Faculty of Health Sciences, Jan Kochanowski University, Kielce, 25-317 Świętokrzyskie, Poland, Department of General Pathomorphology, Medical University of Białystok, Białystok, 15‑269 Podlaskie, Poland, Department of Rheumatology and Internal Diseases, Medical University of Białystok, Białystok, 15‑269 Podlaskie, Poland
  • Pages: 783-787
    |
    Published online on: June 9, 2016
       https://doi.org/10.3892/ol.2016.4692
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Abstract

Periostin, also known as osteoblast-specific factor 2, is a cell‑adhesion protein with pleiotropic properties. The protein serves a vital role in the maintenance and development of tooth and bone tissue, in addition to cardiac development and healing. Periostin levels are increased in several forms of cancer, including pancreatic, ovarian, colon, lung, breast, gastric, thyroid, and esophageal head and neck carcinomas. The present review highlights the key role of periostin in tumorigenesis, particularly in increasing cell survival, invasion, angiogenesis, epithelial‑mesenchymal transition and metastasis of carcinoma cells by interacting with numerous cell‑surface receptors, including integrins, in the phosphoinositide 3-kinase-Akt pathway. In addition, periostin actively affects the canonical Wnt signaling pathway of colorectal tumorigenesis. The current review focused on the involvement of periostin in the development of colorectal, esophageal and gastric cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Moniuszko T, Wincewicz A, Koda M, Domysławska I and Sulkowski S: Role of periostin in esophageal, gastric and colon cancer (Review). Oncol Lett 12: 783-787, 2016.
APA
Moniuszko, T., Wincewicz, A., Koda, M., Domysławska, I., & Sulkowski, S. (2016). Role of periostin in esophageal, gastric and colon cancer (Review). Oncology Letters, 12, 783-787. https://doi.org/10.3892/ol.2016.4692
MLA
Moniuszko, T., Wincewicz, A., Koda, M., Domysławska, I., Sulkowski, S."Role of periostin in esophageal, gastric and colon cancer (Review)". Oncology Letters 12.2 (2016): 783-787.
Chicago
Moniuszko, T., Wincewicz, A., Koda, M., Domysławska, I., Sulkowski, S."Role of periostin in esophageal, gastric and colon cancer (Review)". Oncology Letters 12, no. 2 (2016): 783-787. https://doi.org/10.3892/ol.2016.4692
Copy and paste a formatted citation
x
Spandidos Publications style
Moniuszko T, Wincewicz A, Koda M, Domysławska I and Sulkowski S: Role of periostin in esophageal, gastric and colon cancer (Review). Oncol Lett 12: 783-787, 2016.
APA
Moniuszko, T., Wincewicz, A., Koda, M., Domysławska, I., & Sulkowski, S. (2016). Role of periostin in esophageal, gastric and colon cancer (Review). Oncology Letters, 12, 783-787. https://doi.org/10.3892/ol.2016.4692
MLA
Moniuszko, T., Wincewicz, A., Koda, M., Domysławska, I., Sulkowski, S."Role of periostin in esophageal, gastric and colon cancer (Review)". Oncology Letters 12.2 (2016): 783-787.
Chicago
Moniuszko, T., Wincewicz, A., Koda, M., Domysławska, I., Sulkowski, S."Role of periostin in esophageal, gastric and colon cancer (Review)". Oncology Letters 12, no. 2 (2016): 783-787. https://doi.org/10.3892/ol.2016.4692
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