Nasal dissemination of a single-clone IgH-rearranged conjunctival MALT lymphoma through the nasolacrimal duct: A case report

Hsieh,Chung‑Yu; Liao,Yi‑Ping; Wu,Chia‑Che; Yuan,Sheng‑Po; Ho,Jennifer  Hui‑Chun; Roan,Rachel; Liew,Phui‑Ly; Lai,Ming‑Tang; Lee,Feipeng

doi:10.3892/ol.2016.4700

August-2016 Volume 12 Issue 2

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August-2016 Volume 12 Issue 2

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Case Report

Nasal dissemination of a single-clone IgH-rearranged conjunctival MALT lymphoma through the nasolacrimal duct: A case report

Authors:
- Chung‑Yu Hsieh
- Yi‑Ping Liao
- Chia‑Che Wu
- Sheng‑Po Yuan
- Jennifer Hui‑Chun Ho
- Rachel Roan
- Phui‑Ly Liew
- Ming‑Tang Lai
- Feipeng Lee
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Affiliations: Department of Otolaryngology, Wan Fang Medical Center, Taipei Medical University, Taipei 11698, Taiwan R.O.C., Department of Ophthalmology, Wan Fang Medical Center, Taipei Medical University, Taipei 11698, Taiwan R.O.C., Post‑Baccalaureate Health Professions Program, UC Berkeley Extension, Berkeley, CA 94704, USA, Department of Pathology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan R.O.C.
Pages: 1007-1010
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Published online on: June 10, 2016

https://doi.org/10.3892/ol.2016.4700
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Abstract

The aim of the present study was to report a rare case of single-clone, immunoglobulin heavy chain (IgH)-rearranged mucosa-associated lymphoid tissue (MALT) lymphoma in the conjunctiva, with nasal cavity dissemination through the nasolacrimal duct. A 24-year-old female was diagnosed with MALT lymphoma of the nasal cavity at the Department of Otolaryngology, Wan Fang Medical Center, Taipei Medical University (Tapei, Taiwan) in October 2008. A biopsy of the relapsing conjunctival lesion revealed a MALT lymphoma by pathological staining, while a single-clone, IgH-rearranged tumor lesion in the nasal cavity and conjunctiva was confirmed using continuous sinus computed tomography scans and polymerase chain reaction. Tumor lesions were negative for Helicobacter pylori and Chlamydia infection, but exhibited bilateral neck lymph node dissemination. A combination of radiation therapy (a total dosage of 46.8 Gray, in two phases covering the left lacrimal sac, nasal cavity and bilateral neck region) and topical ciprofloxacin plus steroid (0.3% ciprofloxacin 4 times a day and betamethasone eye ointment before sleep for 1 month) was provided as an effective therapeutic strategy, and no recurrence was found in the next 3 years. The nasolacrimal duct serves as a channel for conjunctival tumor spreading and is easily neglected. IgH‑involved translocation in MALT lymphoma is a factor in the progression of the disease, and aggressive combination therapy is essential for a high-risk, disseminated IgH-rearranged MALT lymphoma.

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1	Sjö LD: Ophthalmic lymphoma: Epidemiology and pathogenesis. Acta Ophthalmol 87 Thesis. 1:1–20. 2009. View Article : Google Scholar
2	Ferry JA, Fung CY, Zukerberg L, Lucarelli MJ, Hasserjian RP, Preffer FI and Harris NL: Lymphoma of the ocular adnexa: A study of 353 cases. Am J Surg Pathol. 31:170–184. 2007. View Article : Google Scholar : PubMed/NCBI
3	Cuadra-Garcia I, Proulx GM, Wu CL, Wang CC, Pilch BZ, Harris NL and Ferry JA: Sinonasal lymphoma: A clinicopathologic analysis of 58 cases from the massachusetts general hospital. Am J Surg Pathol. 23:1356–1369. 1999. View Article : Google Scholar : PubMed/NCBI
4	Yang QP, Zhang WY, Yu JB, Zhao S, Xu H, Wang WY, Bi CF, Zuo Z, Wang XQ, Huang J, et al: Subtype distribution of lymphomas in southwest China: Analysis of 6,382 cases using WHO classification in a single institution. Diagn Pathol. 6:772011. View Article : Google Scholar : PubMed/NCBI
5	Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J and Vardiman JW: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (4th). IARC Press. Lyon: 2008.
6	Demirci H, Shields CL, Karatza EC and Shields JA: Orbital lymphoproliferative tumors: Analysis of clinical features and systemic involvement in 160 cases. Ophthalmology. 115:1626–1631. 2008. View Article : Google Scholar : PubMed/NCBI
7	Kossakowska AE, Eyton-Jones S and Urbanski SJ: Immunoglobulin and T-cell receptor gene rearrangements in lesions of mucosa-associated lymphoid tissue. Diagn Mol Pathol. 2:233–240. 1993. View Article : Google Scholar : PubMed/NCBI
8	Ferreri AJ, Dolcetti R, Du MQ, Doglioni C, Resti AG, Politi LS, De Conciliis C, Radford J, Bertoni F, Zucca E, et al: Ocular adnexal MALT lymphoma: An intriguing model for antigen-driven lymphomagenesis and microbial-targeted therapy. Ann Oncol. 19:835–846. 2008. View Article : Google Scholar : PubMed/NCBI
9	Verma V, Shen D, Sieving PC and Chan CC: The role of infectious agents in the etiology of ocular adnexal neoplasia. Surv Ophthalmol. 53:312–331. 2008. View Article : Google Scholar : PubMed/NCBI
10	Isaacson PG and Du MQ: MALT lymphoma: From morphology to molecules. Nat Rev Cancer. 4:644–653. 2004. View Article : Google Scholar : PubMed/NCBI
11	Ferreri AJ, Ponzoni M, Viale E, Guidoboni M, Conciliis CD, Resti AG, Politi L, Lettini AA, Sacchetti F, Dognini G, et al: Association between Helicobacter pylori infection and MALTtype lymphoma of the ocular adnexa: Clinical and therapeutic implications. Hematol Oncol. 24:33–37. 2006. View Article : Google Scholar : PubMed/NCBI
12	Ferreri AJ, Guidoboni M, Ponzoni M, De Conciliis C, Dell'Oro S, Fleischhauer K, Caggiari L, Lettini AA, Dal Cin E, Ieri R, et al: Evidence for an association between Chlamydia psittaci and ocular adnexal lymphomas. J Natl Cancer Inst. 96:586–594. 2004. View Article : Google Scholar : PubMed/NCBI
13	Matsuo T and Yoshino T: Long-term follow-up results of observation or radiation for conjunctival malignant lymphoma. Ophthalmology. 111:1233–1237. 2004. View Article : Google Scholar : PubMed/NCBI
14	Salepci T, Seker M, Kurnaz E, Guler DO, Bilici A, Dane F, Aliustaoglu M, Atesoglu EB, Gumus M and Yaylaci M: Conjunctival malt lymphoma successfully treated with single agent rituximab therapy. Leuk Res. 33:e10–e13. 2009. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Nasal dissemination of a single-clone IgH-rearranged conjunctival MALT lymphoma through the nasolacrimal duct: A case report

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