Lidocaine inhibits the invasion and migration of TRPV6-expressing cancer cells by TRPV6 downregulation

Corrigendum in: /10.3892/ol.2023.13957

  • Authors:
    • Yuan Jiang
    • Hui Gou
    • Jiang Zhu
    • Si Tian
    • Lehua Yu
  • View Affiliations

  • Published online on: June 13, 2016     https://doi.org/10.3892/ol.2016.4709
  • Pages: 1164-1170
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Abstract

It is well known that local anesthetics have a broad spectrum of pharmacological actions, acting as nerve blocks, and treating pain and cardiac arrhythmias via blocking of the sodium channel. The use of local anesthetics could reduce the possibility of cancer metastasis and recurrence following surgical tumor excision. The purpose of the present study was to investigate the inhibitory effect of lidocaine upon the invasion and migration of transient receptor potential cation channel subfamily V member 6 (TRPV6)‑expressing cancer cells. Human breast cancer MDA‑MB‑231 cells, prostatic cancer PC‑3 cells and ovarian cancer ES‑2 cells were treated with lidocaine. Cell viability was quantitatively determined by MTT assay. The migration of the cells was evaluated using the wound healing assay, and the invasion of the cells was assessed using a Transwell assay. Calcium (Ca2+) measurements were performed using a Fluo‑3 AM fluorescence kit. The expression of TRPV6 mRNA and protein in the cells was determined by quantitative‑polymerase chain reaction and western blot analysis, respectively. The results suggested that lidocaine inhibits the cell invasion and migration of MDA‑MB‑231, PC‑3 and ES‑2 cells at lower than clinical concentrations. The inhibitory effect of lidocaine on TRPV6‑expressing cancer cells was associated with a reduced rate of calcium influx, and could occur partly as a result of the downregulation of TRPV6 expression. The use of appropriate local anesthetics may confer potential benefits in clinical practice for the treatment of patients with TRPV6-expressing cancer.
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August-2016
Volume 12 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Jiang Y, Gou H, Zhu J, Tian S and Yu L: Lidocaine inhibits the invasion and migration of TRPV6-expressing cancer cells by TRPV6 downregulation Corrigendum in /10.3892/ol.2023.13957. Oncol Lett 12: 1164-1170, 2016
APA
Jiang, Y., Gou, H., Zhu, J., Tian, S., & Yu, L. (2016). Lidocaine inhibits the invasion and migration of TRPV6-expressing cancer cells by TRPV6 downregulation Corrigendum in /10.3892/ol.2023.13957. Oncology Letters, 12, 1164-1170. https://doi.org/10.3892/ol.2016.4709
MLA
Jiang, Y., Gou, H., Zhu, J., Tian, S., Yu, L."Lidocaine inhibits the invasion and migration of TRPV6-expressing cancer cells by TRPV6 downregulation Corrigendum in /10.3892/ol.2023.13957". Oncology Letters 12.2 (2016): 1164-1170.
Chicago
Jiang, Y., Gou, H., Zhu, J., Tian, S., Yu, L."Lidocaine inhibits the invasion and migration of TRPV6-expressing cancer cells by TRPV6 downregulation Corrigendum in /10.3892/ol.2023.13957". Oncology Letters 12, no. 2 (2016): 1164-1170. https://doi.org/10.3892/ol.2016.4709