Open Access

Endothelial progenitor cells promote tumor growth and progression by enhancing new vessel formation (Review)

  • Authors:
    • Xin Zhao
    • Huan‑Qiu Liu
    • Ji Li
    • Xiao‑Liang Liu
  • View Affiliations

  • Published online on: June 15, 2016     https://doi.org/10.3892/ol.2016.4733
  • Pages: 793-799
  • Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Tumor growth and progression require new blood vessel formation to deliver nutrients and oxygen for further cell proliferation and to create a neovascular network exit for tumor cell metastasis. Endothelial progenitor cells (EPCs) are a bone marrow (BM)-derived stem cell population that circulates in the peripheral circulation and homes to the tumor bed to participate in new blood vessel formation. In addition to structural support to nascent vessels, these cells can also regulate the angiogenic process by paracrine secretion of a number of proangiogenic growth factors and cytokines, thus playing a crucial role in tumor neovascularization and development. Inhibition of EPC‑mediated new vessel formation may be a promising therapeutic strategy in tumor treatment. EPC‑mediated neovascularization is a complex process that includes multiple steps and requires a series of cytokines and modulators, thus understanding the underlying mechanisms may provide anti‑neovasculogenesis targets that may be blocked for the prevention of tumor development. The present review stresses the process and contribution of EPCs to the formation of new blood vessels in solid tumors, in an attempt to gain an improved understanding of the underlying cellular and molecular mechanisms involved, and to provide a potential effective therapeutic target for cancer treatment.
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August-2016
Volume 12 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Zhao X, Liu HQ, Li J and Liu XL: Endothelial progenitor cells promote tumor growth and progression by enhancing new vessel formation (Review) . Oncol Lett 12: 793-799, 2016
APA
Zhao, X., Liu, H., Li, J., & Liu, X. (2016). Endothelial progenitor cells promote tumor growth and progression by enhancing new vessel formation (Review) . Oncology Letters, 12, 793-799. https://doi.org/10.3892/ol.2016.4733
MLA
Zhao, X., Liu, H., Li, J., Liu, X."Endothelial progenitor cells promote tumor growth and progression by enhancing new vessel formation (Review) ". Oncology Letters 12.2 (2016): 793-799.
Chicago
Zhao, X., Liu, H., Li, J., Liu, X."Endothelial progenitor cells promote tumor growth and progression by enhancing new vessel formation (Review) ". Oncology Letters 12, no. 2 (2016): 793-799. https://doi.org/10.3892/ol.2016.4733