Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
August-2016 Volume 12 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2016 Volume 12 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Endothelial progenitor cells promote tumor growth and progression by enhancing new vessel formation (Review)

  • Authors:
    • Xin Zhao
    • Huan‑Qiu Liu
    • Ji Li
    • Xiao‑Liang Liu
  • View Affiliations / Copyright

    Affiliations: Cancer Center, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Anesthesiology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 793-799
    |
    Published online on: June 15, 2016
       https://doi.org/10.3892/ol.2016.4733
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Tumor growth and progression require new blood vessel formation to deliver nutrients and oxygen for further cell proliferation and to create a neovascular network exit for tumor cell metastasis. Endothelial progenitor cells (EPCs) are a bone marrow (BM)-derived stem cell population that circulates in the peripheral circulation and homes to the tumor bed to participate in new blood vessel formation. In addition to structural support to nascent vessels, these cells can also regulate the angiogenic process by paracrine secretion of a number of proangiogenic growth factors and cytokines, thus playing a crucial role in tumor neovascularization and development. Inhibition of EPC‑mediated new vessel formation may be a promising therapeutic strategy in tumor treatment. EPC‑mediated neovascularization is a complex process that includes multiple steps and requires a series of cytokines and modulators, thus understanding the underlying mechanisms may provide anti‑neovasculogenesis targets that may be blocked for the prevention of tumor development. The present review stresses the process and contribution of EPCs to the formation of new blood vessels in solid tumors, in an attempt to gain an improved understanding of the underlying cellular and molecular mechanisms involved, and to provide a potential effective therapeutic target for cancer treatment.
View Figures

Figure 1

Figure 2

View References

1 

Global Burden of Disease Cancer Collaboration. Fitzmaurice C, Dicker D, Pain A, et al: The global burden of cancer 2013. JAMA Oncol. 1:505–527. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Janic B and Arbab AS: The role and therapeutic potential of endothelial progenitor cells in tumor neovascularization. Scientific World Journal. 10:1088–1099. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Kerbel RS: Tumor angiogenesis: Past, present and the near future. Carcinogenesis. 21:505–515. 2000. View Article : Google Scholar : PubMed/NCBI

4 

Folkman J and Shing Y: Angiogenesis. J Biol Chem. 267:10931–10934. 1992.PubMed/NCBI

5 

Folkman J: Seminars in medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. N Engl J Med. 333:1757–1763. 1995. View Article : Google Scholar : PubMed/NCBI

6 

Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, Witzenbichler B, Schatteman G and Isner JM: Isolation of putative progenitor endothelial cells for angiogenesis. Science. 275:964–967. 1997. View Article : Google Scholar : PubMed/NCBI

7 

Moubarik C, Guillet B, Youssef B, Codaccioni JL, Piercecchi MD, Sabatier F, Lionel P, Dou L, Foucault-Bertaud A, Velly L, et al: Transplanted late outgrowth endothelial progenitor cells as cell therapy product for stroke. Stem Cell Rev. 7:208–220. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Nolan DJ, Ciarrocchi A, Mellick AS, Jaggi JS, Bambino K, Gupta S, Heikamp E, McDevitt MR, Scheinberg DA, Benezra R and Mittal V: Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization. Genes Dev. 21:1546–1558. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Folkins C, Shaked Y, Man S, Tang T, Lee CR, Zhu Z, Hoffman RM and Kerbel RS: Glioma tumor stem-like cells promote tumor angiogenesis and vasculogenesis via vascular endothelial growth factor and stromal-derived factor 1. Cancer Res. 69:7243–7251. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Zhang HR, Chen FL, Xu CP, Ping YF, Wang QL, Liang ZQ, Wang JM and Bian XW: Incorporation of endothelial progenitor cells into the neovasculature of malignant glioma xenograft. J Neurooncol. 93:165–174. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Chen X, Fang J, Wang S, Liu H, Du X, Chen J, Li X, Yang Y, Zhang B and Zhang W: A new mosaic pattern in glioma vascularization: Exogenous endothelial progenitor cells integrating into the vessels containing tumor-derived endothelial cells. Oncotarget. 5:1955–1968. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Russell JS and Brown JM: Circulating mouse Flk1+/c-Kit+/CD45− cells function as endothelial progenitors cells (EPCs) and stimulate the growth of human tumor xenografts. Mol Cancer. 13:1772014. View Article : Google Scholar : PubMed/NCBI

13 

Lee PS and Poh KK: Endothelial progenitor cells in cardiovascular diseases. World J Stem Cells. 6:355–366. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Rouhl RP, van Oostenbrugge RJ, Damoiseaux J, Tervaert JW and Lodder J: Endothelial progenitor cell research in stroke: A potential shift in pathophysiological and therapeutical concepts. Stroke. 39:2158–2165. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Fadini GP, Losordo D and Dimmeler S: Critical reevaluation of endothelial progenitor cell phenotypes for therapeutic and diagnostic use. Circ Res. 110:624–637. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Hur J, Yoon CH, Kim HS, Choi JH, Kang HJ, Hwang KK, Oh BH, Lee MM and Park YB: Characterization of two types of endothelial progenitor cells and their different contributions to neovasculogenesis. Arterioscler Thromb Vasc Biol. 24:288–293. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Hristov M, Erl W and Weber PC: Endothelial progenitor cells: Mobilization, differentiation and homing. Arterioscler Thromb Vasc Biol. 23:1185–1189. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Walenta KL, Bettink S, Böhm M and Friedrich EB: Differential chemokine receptor expression regulates functional specialization of endothelial progenitor cell subpopulations. Basic Res Cardiol. 106:299–305. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Gehling UM, Ergün S, Schumacher U, Wagener C, Pantel K, Otte M, Schuch G, Schafhausen P, Mende T, Kilic N, et al: In vitro differentiation of endothelial cells from AC133-positive progenitor cells. Blood. 95:3106–3112. 2000.PubMed/NCBI

20 

Peichev M, Naiyer AJ, Pereira D, Zhu Z, Lane WJ, Williams M, Oz MC, Hicklin DJ, Witte L, Moore MA and Rafii S: Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors. Blood. 95:952–958. 2000.PubMed/NCBI

21 

Khakoo AY and Finkel T: Endothelial progenitor cells. Annu Rev Med. 56:79–101. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Shantsila E, Watson T and Lip GY: Endothelial progenitor cells in cardiovascular disorders. J Am Coll Cardiol. 49:741–752. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Kawamoto A, Gwon HC, Iwaguro H, Yamaguchi JI, Uchida S, Masuda H, Silver M, Ma H, Kearney M, Isner JM and Asahara T: Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia. Circulation. 103:634–637. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Kawamoto A, Tkebuchava T, Yamaguchi J, Nishimura H, Yoon YS, Milliken C, Uchida S, Masuo O, Iwaguro H, Ma H, et al: Intramyocardial transplantation of autologous endothelial progenitor cells for therapeutic neovascularization of myocardial ischemia. Circulation. 107:461–468. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Zhang ZG, Zhang L, Jiang Q and Chopp M: Bone marrow-derived endothelial progenitor cells participate in cerebral neovascularization after focal cerebral ischemia in the adult mouse. Circ Res. 90:284–288. 2002. View Article : Google Scholar : PubMed/NCBI

26 

Fan Y, Shen F, Frenzel T, Zhu W, Ye J, Liu J, Chen Y, Su H, Young WL and Yang GY: Endothelial progenitor cell transplantation improves long-term stroke outcome in mice. Ann Neurol. 67:488–497. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Yamaguchi J, Kusano KF, Masuo O, Kawamoto A, Silver M, Murasawa S, Bosch-Marce M, Masuda H, Losordo DW, Isner JM and Asahara T: Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization. Circulation. 107:1322–1328. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Liu ZJ and Velazquez OC: Hyperoxia, endothelial progenitor cell mobilization, and diabetic wound healing. Antioxid Redox Signal. 10:1869–1882. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Dome B, Timar J, Ladanyi A, Paku S, Renyi-Vamos F, Klepetko W, Lang G, Dome P, Bogos K and Tovari J: Circulating endothelial cells, bone marrow-derived endothelial progenitor cells and proangiogenic hematopoietic cells in cancer: From biology to therapy. Crit Rev Oncol Hematol. 69:108–124. 2009. View Article : Google Scholar : PubMed/NCBI

30 

de la Puente P, Muz B, Azab F and Azab AK: Cell trafficking of endothelial progenitor cells in tumor progression. Clin Cancer Res. 19:3360–3368. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Tazzyman S, Lewis CE and Murdoch C: Neutrophils: Key mediators of tumour angiogenesis. Int J Exp Pathol. 90:222–231. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Folkman J: Role of angiogenesis in tumor growth and metastasis. Semin Oncol. 29(6 Suppl 16): S15–S18. 2002. View Article : Google Scholar

33 

Rak J, Filmus J and Kerbel RS: Reciprocal paracrine interactions between tumour cells and endothelial cells: The ‘angiogenesis progression’ hypothesis. Eur J Cancer. 32A:2438–2450. 1996. View Article : Google Scholar : PubMed/NCBI

34 

Folkman J: Angiogenesis-dependent diseases. Semin Oncol. 28:536–542. 2001. View Article : Google Scholar : PubMed/NCBI

35 

Folkman J: Angiogenesis and apoptosis. Semin Cancer Biol. 13:159–167. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Fidler IJ and Ellis LM: The implications of angiogenesis for the biology and therapy of cancer metastasis. Cell. 79:185–188. 1994. View Article : Google Scholar : PubMed/NCBI

37 

Urbich C and Dimmeler S: Endothelial progenitor cells: Characterization and role in vascular biology. Circ Res. 95:343–353. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Li Calzi S, Neu MB, Shaw LC, Kielczewski JL, Moldovan NI and Grant MB: EPCs and pathological angiogenesis: When good cells go bad. Microvasc Res. 79:207–216. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Xu XH, Pan W, Kang LH, Feng H and Song YQ: Association of annexin A2 with cancer development (Review). Oncol Rep. 33:2121–2128. 2015.PubMed/NCBI

40 

Urbich C, Aicher A, Heeschen C, Dernbach E, Hofmann WK, Zeiher AM and Dimmeler S: Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells. J Mol Cell Cardiol. 39:733–742. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Lyden D, Hattori K, Dias S, Costa C, Blaikie P, Butros L, Chadburn A, Heissig B, Marks W, Witte L, et al: Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat Med. 7:1194–1201. 2001. View Article : Google Scholar : PubMed/NCBI

42 

Hristov M and Weber C: Endothelial progenitor cells: Characterization, pathophysiology, and possible clinical relevance. J Cell Mol Med. 8:498–508. 2004. View Article : Google Scholar : PubMed/NCBI

43 

Hristov M, Erl W and Weber PC: Endothelial progenitor cells: Isolation and characterization. Trends Cardiovasc Med. 13:201–206. 2003. View Article : Google Scholar : PubMed/NCBI

44 

Stoll BR, Migliorini C, Kadambi A, Munn LL and Jain RK: A mathematical model of the contribution of endothelial progenitor cells to angiogenesis in tumors: Implications for antiangiogenic therapy. Blood. 102:2555–2561. 2003. View Article : Google Scholar : PubMed/NCBI

45 

Nozawa H, Chiu C and Hanahan D: Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis. Proc Natl Acad Sci USA. 103:12493–12498. 2006. View Article : Google Scholar : PubMed/NCBI

46 

Shojaei F, Wu X, Malik AK, Zhong C, Baldwin ME, Schanz S, Fuh G, Gerber HP and Ferrara N: Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells. Nat Biotechnol. 25:911–920. 2007. View Article : Google Scholar : PubMed/NCBI

47 

Li DW, Liu ZQ, Wei J, Liu Y and Hu LS: Contribution of endothelial progenitor cells to neovascularization (Review). Int J Mol Med. 30:1000–1006. 2012.PubMed/NCBI

48 

Lapidot T and Petit I: Current understanding of stem cell mobilization: The roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines and stromal cells. Exp Hematol. 30:973–981. 2002. View Article : Google Scholar : PubMed/NCBI

49 

Lapidot T, Dar A and Kollet O: How do stem cells find their way home? Blood. 106:1901–1910. 2005. View Article : Google Scholar : PubMed/NCBI

50 

Ferrara N and Alitalo K: Clinical applications of angiogenic growth factors and their inhibitors. Nat Med. 5:1359–1364. 1999. View Article : Google Scholar : PubMed/NCBI

51 

Asahara T, Takahashi T, Masuda H, Kalka C, Chen D, Iwaguro H, Inai Y, Silver M, Isner JM, et al: VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells. EMBO J. 18:3964–3972. 1999. View Article : Google Scholar : PubMed/NCBI

52 

Kalka C, Masuda H, Takahashi T, Gordon R, Tepper O, Gravereaux E, Pieczek A, Iwaguro H, Hayashi SI, Isner JM and Asahara T: Vascular endothelial growth factor(165) gene transfer augments circulating endothelial progenitor cells in human subjects. Circ Res. 86:1198–1202. 2000. View Article : Google Scholar : PubMed/NCBI

53 

Hattori K, Dias S, Heissig B, Hackett NR, Lyden D, Tateno M, Hicklin DJ, Zhu Z, Witte L, Crystal RG, et al: Vascular endothelial growth factor and angiopoietin-1 stimulate postnatal hematopoiesis by recruitment of vasculogenic and hematopoietic stem cells. J Exp Med. 193:1005–1014. 2001. View Article : Google Scholar : PubMed/NCBI

54 

Kopp HG, Ramos CA and Rafii S: Contribution of endothelial progenitors and proangiogenic hematopoietic cells to vascularization of tumor and ischemic tissue. Curr Opin Hematol. 13:175–181. 2006. View Article : Google Scholar : PubMed/NCBI

55 

Kopp HG, Avecilla ST, Hooper AT and Rafii S: The bone marrow vascular niche: Home of HSC differentiation and mobilization. Physiology (Bethesda). 20:349–356. 2005. View Article : Google Scholar : PubMed/NCBI

56 

Heissig B, Hattori K, Dias S, Friedrich M, Ferris B, Hackett NR, Crystal RG, Besmer P, Lyden D, Moore MA, et al: Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell. 109:625–637. 2002. View Article : Google Scholar : PubMed/NCBI

57 

Powell TM, Paul JD, Hill JM, Thompson M, Benjamin M, Rodrigo M, McCoy JP, Read EJ, Khuu HM, Leitman SF, et al: Granulocyte colony-stimulating factor mobilizes functional endothelial progenitor cells in patients with coronary artery disease. Arterioscler Thromb Vasc Biol. 25:296–301. 2005. View Article : Google Scholar : PubMed/NCBI

58 

Lévesque JP, Takamatsu Y, Nilsson SK, Haylock DN and Simmons PJ: Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor. Blood. 98:1289–1297. 2001. View Article : Google Scholar : PubMed/NCBI

59 

Chang EI, Chang EI, Thangarajah H, Hamou C and Gurtner GC: Hypoxia, hormones, and endothelial progenitor cells in hemangioma. Lymphat Res Biol. 5:237–243. 2007. View Article : Google Scholar : PubMed/NCBI

60 

Ling CC, Ng KT, Shao Y, Geng W, Xiao JW, Liu H, Li CX, Liu XB, Ma YY, Yeung WH, et al: Post-transplant endothelial progenitor cell mobilization via CXCL10/CXCR3 signaling promotes liver tumor growth. J Hepatol. 60:103–109. 2014. View Article : Google Scholar : PubMed/NCBI

61 

Spring H, Schüler T, Arnold B, Hämmerling GJ and Ganss R: Chemokines direct endothelial progenitors into tumor neovessels. Proc Natl Acad Sci USA. 102:18111–18116. 2005. View Article : Google Scholar : PubMed/NCBI

62 

Shibata R, Skurk C, Ouchi N, Galasso G, Kondo K, Ohashi T, Shimano M, Kihara S, Murohara T and Walsh K: Adiponectin promotes endothelial progenitor cell number and function. FEBS Lett. 582:1607–1612. 2008. View Article : Google Scholar : PubMed/NCBI

63 

Nakamura N, Naruse K, Matsuki T, Hamada Y, Nakashima E, Kamiya H, Matsubara T, Enomoto A, Takahashi M, Oiso Y and Nakamura J: Adiponectin promotes migration activities of endothelial progenitor cells via Cdc42/Rac1. FEBS Lett. 583:2457–2463. 2009. View Article : Google Scholar : PubMed/NCBI

64 

Landskroner-Eiger S, Qian B, Muise ES, Nawrocki AR, Berger JP, Fine EJ, Koba W, Deng Y, Pollard JW and Scherer PE: Proangiogenic contribution of adiponectin toward mammary tumor growth in vivo. Clin Cancer Res. 15:3265–3276. 2009. View Article : Google Scholar : PubMed/NCBI

65 

Kucia M, Reca R, Miekus K, Wanzeck J, Wojakowski W, Janowska-Wieczorek A, Ratajczak J and Ratajczak MZ: Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: Pivotal role of the SDF-1-CXCR4 axis. Stem Cells. 23:879–894. 2005. View Article : Google Scholar : PubMed/NCBI

66 

Ceradini DJ, Kulkarni AR, Callaghan MJ, Tepper OM, Bastidas N, Kleinman ME, Capla JM, Galiano RD, Levine JP and Gurtner GC: Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med. 10:858–864. 2004. View Article : Google Scholar : PubMed/NCBI

67 

Bhakta S, Hong P and Koc O: The surface adhesion molecule CXCR4 stimulates mesenchymal stem cell migration to stromal cell-derived factor-1 in vitro but does not decrease apoptosis under serum deprivation. Cardiovasc Revasc Med. 7:19–24. 2006. View Article : Google Scholar : PubMed/NCBI

68 

Kryczek I, Lange A, Mottram P, Alvarez X, Cheng P, Hogan M, Moons L, Wei S, Zou L, Machelon V, et al: CXCL12 and vascular endothelial growth factor synergistically induce neoangiogenesis in human ovarian cancers. Cancer Res. 65:465–472. 2005.PubMed/NCBI

69 

Darash-Yahana M, Pikarsky E, Abramovitch R, Zeira E, Pal B, Karplus R, Beider K, Avniel S, Kasem S, Galun E and Peled A: Role of high expression levels of CXCR4 in tumor growth, vascularization and metastasis. FASEB J. 18:1240–1242. 2004.PubMed/NCBI

70 

Pugh CW and Ratcliffe PJ: Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med. 9:677–684. 2003. View Article : Google Scholar : PubMed/NCBI

71 

Kollet O, Shivtiel S, Chen YQ, Suriawinata J, Thung SN, Dabeva MD, Kahn J, Spiegel A, Dar A, Samira S, et al: HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver. J Clin Invest. 112:160–169. 2003. View Article : Google Scholar : PubMed/NCBI

72 

Askari AT, Unzek S, Popovic ZB, Goldman CK, Forudi F, Kiedrowski M, Rovner A, Ellis SG, Thomas JD, DiCorleto PE, et al: Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy. Lancet. 362:697–703. 2003. View Article : Google Scholar : PubMed/NCBI

73 

Arbab AS, Janic B, Knight RA, Anderson SA, Pawelczyk E, Rad AM, Read EJ, Pandit SD and Frank JA: Detection of migration of locally implanted AC133+ stem cells by cellular magnetic resonance imaging with histological findings. FASEB J. 22:3234–3246. 2008. View Article : Google Scholar : PubMed/NCBI

74 

Gallagher KA, Liu ZJ, Xiao M, Chen H, Goldstein LJ, Buerk DG, Nedeau A, Thom SR and Velazquez OC: Diabetic impairments in NO-mediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF-1 alpha. J Clin Invest. 117:1249–1259. 2007. View Article : Google Scholar : PubMed/NCBI

75 

Abbott JD, Huang Y, Liu D, Hickey R, Krause DS and Giordano FJ: Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury. Circulation. 110:3300–3305. 2004. View Article : Google Scholar : PubMed/NCBI

76 

Walter DH, Haendeler J, Reinhold J, Rochwalsky U, Seeger F, Honold J, Hoffmann J, Urbich C, Lehmann R, Arenzana-Seisdesdos F, et al: Impaired CXCR4 signaling contributes to the reduced neovascularization capacity of endothelial progenitor cells from patients with coronary artery disease. Circ Res. 97:1142–1151. 2005. View Article : Google Scholar : PubMed/NCBI

77 

Sun X, Cheng G, Hao M, Zheng J, Zhou X, Zhang J, Taichman RS, Pienta KJ and Wang J: CXCL12/CXCR4/CXCR7 chemokine axis and cancer progression. Cancer Metastasis Rev. 29:709–722. 2010. View Article : Google Scholar : PubMed/NCBI

78 

Vajkoczy P, Blum S, Lamparter M, Mailhammer R, Erber R, Engelhardt B, Vestweber D and Hatzopoulos AK: Multistep nature of microvascular recruitment of ex vivo-expanded embryonic endothelial progenitor cells during tumor angiogenesis. J Exp Med. 197:1755–1765. 2003. View Article : Google Scholar : PubMed/NCBI

79 

Di Santo S, Diehm N, Ortmann J, Völzmann J, Yang Z, Keo HH, Baumgartner I and Kalka C: Oxidized low density lipoprotein impairs endothelial progenitor cell function by downregulation of E-selectin and integrin alpha(v)beta5. Biochem Biophys Res Commun. 373:528–532. 2008. View Article : Google Scholar : PubMed/NCBI

80 

Lapidot T: Mechanism of human stem cell migration and repopulation of NOD/SCID and B2mnull NOD/SCID mice. The role of SDF-1/CXCR4 interactions. Ann N Y Acad Sci. 938:83–95. 2001. View Article : Google Scholar : PubMed/NCBI

81 

Chavakis E, Aicher A, Heeschen C, Sasaki K, Kaiser R, El Makhfi N, Urbich C, Peters T, Scharffetter-Kochanek K, Zeiher AM, et al: Role of beta2-integrins for homing and neovascularization capacity of endothelial progenitor cells. J Exp Med. 201:63–72. 2005. View Article : Google Scholar : PubMed/NCBI

82 

Carmona G, Chavakis E, Koehl U, Zeiher AM and Dimmeler S: Activation of Epac stimulates integrin-dependent homing of progenitor cells. Blood. 111:2640–2646. 2008. View Article : Google Scholar : PubMed/NCBI

83 

Bauters C, Marotte F, Hamon M, Oliviéro P, Farhadian F, Robert V, Samuel JL and Rappaport L: Accumulation of fetal fibronectin mRNAs after balloon denudation of rabbit arteries. Circulation. 92:904–911. 1995. View Article : Google Scholar : PubMed/NCBI

84 

Chavakis E, Hain A, Vinci M, Carmona G, Bianchi ME, Vajkoczy P, Zeiher AM, Chavakis T and Dimmeler S: High-mobility group box 1 activates integrin-dependent homing of endothelial progenitor cells. Circ Res. 100:204–212. 2007. View Article : Google Scholar : PubMed/NCBI

85 

Caiado F and Dias S: Endothelial progenitor cells and integrins: Adhesive needs. Fibrogenesis Tissue Repair. 5:42012. View Article : Google Scholar : PubMed/NCBI

86 

Hanjaya-Putra D, Yee J, Ceci D, Truitt R, Yee D and Gerecht S: Vascular endothelial growth factor and substrate mechanics regulate in vitro tubulogenesis of endothelial progenitor cells. J Cell Mol Med. 14:2436–2447. 2010. View Article : Google Scholar : PubMed/NCBI

87 

Jin H, Aiyer A, Su J, Borgstrom P, Stupack D, Friedlander M and Varner J: A homing mechanism for bone marrow-derived progenitor cell recruitment to the neovasculature. J Clin Invest. 116:652–662. 2006. View Article : Google Scholar : PubMed/NCBI

88 

Qin G, Ii M, Silver M, Wecker A, Bord E, Ma H, Gavin M, Goukassian DA, Yoon YS, Papayannopoulou T, et al: Functional disruption of alpha4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularization. J Exp Med. 203:153–163. 2006. View Article : Google Scholar : PubMed/NCBI

89 

Hall K and Ran S: Regulation of tumor angiogenesis by the local environment. Front Biosci (Landmark Ed). 15:195–212. 2010. View Article : Google Scholar : PubMed/NCBI

90 

McKeage MJ and Baguley BC: Disrupting established tumor blood vessels: An emerging therapeutic strategy for cancer. Cancer. 116:1859–1871. 2010. View Article : Google Scholar : PubMed/NCBI

91 

Folkman J: Tumor angiogenesis: Therapeutic implications. N Engl J Med. 285:1182–1186. 1971. View Article : Google Scholar : PubMed/NCBI

92 

Ribatti D, Vacca A and Dammacco F: The role of the vascular phase in solid tumor growth: A historical review. Neoplasia. 1:293–302. 1999. View Article : Google Scholar : PubMed/NCBI

93 

Tosetti F, Ferrari N, De Flora S and Albini A: Angioprevention': Angiogenesis is a common and key target for cancer chemopreventive agents. FASEB J. 16:2–14. 2002. View Article : Google Scholar : PubMed/NCBI

94 

Albini A, Noonan DM and Ferrari N: Molecular pathways for cancer angioprevention. Clin Cancer Res. 13:4320–4325. 2007. View Article : Google Scholar : PubMed/NCBI

95 

Li WW, Li VW, Hutnik M and Chiou AS: Tumor angiogenesis as a target for dietary cancer prevention. J Oncol. 2012:8796232012. View Article : Google Scholar : PubMed/NCBI

96 

Zhao YH, Yuan B, Chen J, Feng DH, Zhao B, Qin C and Chen YF: Endothelial progenitor cells: Therapeutic perspective for ischemic stroke. CNS Neurosci Ther. 19:67–75. 2013. View Article : Google Scholar : PubMed/NCBI

97 

Peters BA, Diaz LA, Polyak K, Meszler L, Romans K, Guinan EC, Antin JH, Myerson D, Hamilton SR, Vogelstein B, et al: Contribution of bone marrow-derived endothelial cells to human tumor vasculature. Nat Med. 11:261–262. 2005. View Article : Google Scholar : PubMed/NCBI

98 

Murakami J, Li TS, Ueda K, Tanaka T and Hamano K: Inhibition of accelerated tumor growth by blocking the recruitment of mobilized endothelial progenitor cells after chemotherapy. Int J Cancer. 124:1685–1692. 2009. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhao X, Liu HQ, Li J and Liu XL: Endothelial progenitor cells promote tumor growth and progression by enhancing new vessel formation (Review) . Oncol Lett 12: 793-799, 2016.
APA
Zhao, X., Liu, H., Li, J., & Liu, X. (2016). Endothelial progenitor cells promote tumor growth and progression by enhancing new vessel formation (Review) . Oncology Letters, 12, 793-799. https://doi.org/10.3892/ol.2016.4733
MLA
Zhao, X., Liu, H., Li, J., Liu, X."Endothelial progenitor cells promote tumor growth and progression by enhancing new vessel formation (Review) ". Oncology Letters 12.2 (2016): 793-799.
Chicago
Zhao, X., Liu, H., Li, J., Liu, X."Endothelial progenitor cells promote tumor growth and progression by enhancing new vessel formation (Review) ". Oncology Letters 12, no. 2 (2016): 793-799. https://doi.org/10.3892/ol.2016.4733
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao X, Liu HQ, Li J and Liu XL: Endothelial progenitor cells promote tumor growth and progression by enhancing new vessel formation (Review) . Oncol Lett 12: 793-799, 2016.
APA
Zhao, X., Liu, H., Li, J., & Liu, X. (2016). Endothelial progenitor cells promote tumor growth and progression by enhancing new vessel formation (Review) . Oncology Letters, 12, 793-799. https://doi.org/10.3892/ol.2016.4733
MLA
Zhao, X., Liu, H., Li, J., Liu, X."Endothelial progenitor cells promote tumor growth and progression by enhancing new vessel formation (Review) ". Oncology Letters 12.2 (2016): 793-799.
Chicago
Zhao, X., Liu, H., Li, J., Liu, X."Endothelial progenitor cells promote tumor growth and progression by enhancing new vessel formation (Review) ". Oncology Letters 12, no. 2 (2016): 793-799. https://doi.org/10.3892/ol.2016.4733
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team