MicroRNA-206 inhibits the viability and migration of human lung adenocarcinoma cells partly by targeting MET

  • Authors:
    • Xi Chen
    • Zhong‑Kai Tong
    • Jian‑Ya Zhou
    • Ya‑Ke Yao
    • Shu‑Meng Zhang
    • Jian‑Ying Zhou
  • View Affiliations

  • Published online on: June 15, 2016     https://doi.org/10.3892/ol.2016.4735
  • Pages: 1171-1177
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Abstract

MicroRNA (miRNA)-based targeting in cancer has emerged as a potential therapeutic strategy. miR‑206 has recently been implicated in cancer. However, the role and molecular mechanism of miR‑206 in lung adenocarcinoma are still unclear. The present study revealed that miR‑206 was downregulated in human lung adenocarcinoma tissues. Overexpression of miR‑206 in human lung adenocarcinoma‑derived cells significantly inhibited cell viability and migration. Further experiments indicated that the overexpression of miR‑206 decreased the expression of MET at the messenger RNA and protein levels via direct targeting of MET in a 3'‑untranslated region‑dependent manner. The knockdown of MET by small interfering RNA partly led to a phenocopy effect of miR‑206. In conclusion, the present study identified miR‑206 as a potential tumor suppressor of lung adenocarcinoma that exerts its functions, in part, by negative regulation of MET.
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August-2016
Volume 12 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Chen X, Tong ZK, Zhou JY, Yao YK, Zhang SM and Zhou JY: MicroRNA-206 inhibits the viability and migration of human lung adenocarcinoma cells partly by targeting MET. Oncol Lett 12: 1171-1177, 2016
APA
Chen, X., Tong, Z., Zhou, J., Yao, Y., Zhang, S., & Zhou, J. (2016). MicroRNA-206 inhibits the viability and migration of human lung adenocarcinoma cells partly by targeting MET. Oncology Letters, 12, 1171-1177. https://doi.org/10.3892/ol.2016.4735
MLA
Chen, X., Tong, Z., Zhou, J., Yao, Y., Zhang, S., Zhou, J."MicroRNA-206 inhibits the viability and migration of human lung adenocarcinoma cells partly by targeting MET". Oncology Letters 12.2 (2016): 1171-1177.
Chicago
Chen, X., Tong, Z., Zhou, J., Yao, Y., Zhang, S., Zhou, J."MicroRNA-206 inhibits the viability and migration of human lung adenocarcinoma cells partly by targeting MET". Oncology Letters 12, no. 2 (2016): 1171-1177. https://doi.org/10.3892/ol.2016.4735