Rapid progression of mixed neuroendocrine carcinoma‑acinar adenocarcinoma of the prostate: A case report

  • Authors:
    • Jingchao Wei
    • Xiaoping Zheng
    • Liuxun Li
    • Wensu Wei
    • Zhi Long
    • Leye He
  • View Affiliations

  • Published online on: June 16, 2016     https://doi.org/10.3892/ol.2016.4737
  • Pages: 1019-1022
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Abstract

The current study presents the case of a 78‑year‑old male with mixed neuroendocrine (NE) carcinoma‑acinar adenocarcinoma of the prostate. The patient received endocrine therapy (maximal androgen blockade) after the initial diagnosis resulting in a significant decrease in serum prostate‑specific antigen (PSA) level. The patient underwent transurethral resection of the prostate after 6 months of androgen‑deprivation therapy for extraordinarily salient difficulty in urination, and histopathology demonstrated mixed NE carcinoma‑acinar adenocarcinoma once again. The NE prostate cancer progressed rapidly even though the serum PSA was controlled at a low level on account of the endocrine therapy. Previous treatment protocols were replaced by combined chemotherapy and endocrine therapy, and the patient responded well. The patient's serum PSA remained at a low level, however, urethral dilatation for acute urinary retention was required again 5 months later and the lower urinary tract symptoms became increasingly evident. The patient eventually died of cachexia.. These findings indicate that mixed NE carcinoma‑acinar adenocarcinoma has a higher degree of malignancy and that endocrine therapy for prostate cancer has a propensity to facilitate progression of this tumor.
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August-2016
Volume 12 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wei J, Zheng X, Li L, Wei W, Long Z and He L: Rapid progression of mixed neuroendocrine carcinoma‑acinar adenocarcinoma of the prostate: A case report. Oncol Lett 12: 1019-1022, 2016
APA
Wei, J., Zheng, X., Li, L., Wei, W., Long, Z., & He, L. (2016). Rapid progression of mixed neuroendocrine carcinoma‑acinar adenocarcinoma of the prostate: A case report. Oncology Letters, 12, 1019-1022. https://doi.org/10.3892/ol.2016.4737
MLA
Wei, J., Zheng, X., Li, L., Wei, W., Long, Z., He, L."Rapid progression of mixed neuroendocrine carcinoma‑acinar adenocarcinoma of the prostate: A case report". Oncology Letters 12.2 (2016): 1019-1022.
Chicago
Wei, J., Zheng, X., Li, L., Wei, W., Long, Z., He, L."Rapid progression of mixed neuroendocrine carcinoma‑acinar adenocarcinoma of the prostate: A case report". Oncology Letters 12, no. 2 (2016): 1019-1022. https://doi.org/10.3892/ol.2016.4737