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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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August-2016 Volume 12 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Case Report

Rapid progression of mixed neuroendocrine carcinoma‑acinar adenocarcinoma of the prostate: A case report

  • Authors:
    • Jingchao Wei
    • Xiaoping Zheng
    • Liuxun Li
    • Wensu Wei
    • Zhi Long
    • Leye He
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China
  • Pages: 1019-1022
    |
    Published online on: June 16, 2016
       https://doi.org/10.3892/ol.2016.4737
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Abstract

The current study presents the case of a 78‑year‑old male with mixed neuroendocrine (NE) carcinoma‑acinar adenocarcinoma of the prostate. The patient received endocrine therapy (maximal androgen blockade) after the initial diagnosis resulting in a significant decrease in serum prostate‑specific antigen (PSA) level. The patient underwent transurethral resection of the prostate after 6 months of androgen‑deprivation therapy for extraordinarily salient difficulty in urination, and histopathology demonstrated mixed NE carcinoma‑acinar adenocarcinoma once again. The NE prostate cancer progressed rapidly even though the serum PSA was controlled at a low level on account of the endocrine therapy. Previous treatment protocols were replaced by combined chemotherapy and endocrine therapy, and the patient responded well. The patient's serum PSA remained at a low level, however, urethral dilatation for acute urinary retention was required again 5 months later and the lower urinary tract symptoms became increasingly evident. The patient eventually died of cachexia.. These findings indicate that mixed NE carcinoma‑acinar adenocarcinoma has a higher degree of malignancy and that endocrine therapy for prostate cancer has a propensity to facilitate progression of this tumor.
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1 

Aggarwal R, Zhang T, Small EJ and Armstrong AJ: Neuroendocrine prostate cancer: Subtypes, biology, and clinical outcomes. J Natl Compr Canc Netw. 12:719–726. 2014.PubMed/NCBI

2 

Wang HT, Yao YH, Li BG, Tang Y, Chang JW and Zhang J: Neuroendocrine Prostate Cancer (NEPC) progressing from conventional prostatic adenocarcinoma: Factors associated with time to development of NEPC and survival from NEPC diagnosis - a systematic review and pooled analysis. J Clin Oncol. 32:3383–3390. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Marcus DM, Goodman M, Jani AB, Osunkoya AO and Rossi PJ: A comprehensive review of incidence and survival in patients with rare histological variants of prostate cancer in the United States from 1973 to 2008. Prostate Cancer Prostatic Dis. 15:283–288. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Fléchon A, Pouessel D, Ferlay C, Perol D, Beuzeboc P, Gravis G, Joly F, Oudard S, Deplanque G, Zanetta S, et al: Phase II study of carboplatin and etoposide in patients with anaplastic progressive metastatic castration-resistant prostate cancer (mCRPC) with or without neuroendocrine differentiation: Results of the French Genito-Urinary Tumor Group (GETUG) P01 trial. Ann Oncol. 22:2476–2481. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Fjällskog ML, Granberg DP, Welin SL, Eriksson C, Oberg KE, Janson ET and Eriksson BK: Treatment with cisplatin and etoposide in patients with neuroendocrine tumors. Cancer. 92:1101–1107. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Palmgren JS, Karavadia SS and Wakefield MR: Unusual and underappreciated: Small cell carcinoma of the prostate. Semin Oncol. 34:22–29. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Chung MS, Lee SH, Lee DH and Chung BH: Evaluation of the 7th American Joint Committee on cancer TNM staging system for prostate cancer in point of classification of bladder neck invasion. Jpn J Clin Oncol. 43:184–188. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Lipianskaya J, Cohen A, Chen CJ, Hsia E, Squires J, Li Z, Zhang Y, Li W, Chen X, Xu H and Huang J: Androgen-deprivation therapy-induced aggressive prostate cancer with neuroendocrine differentiation. Asian J Androl. 16:541–544. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Beltran H, Tagawa ST, Park K, MacDonald T, Milowsky MI, Mosquera JM, Rubin MA and Nanus DM: Challenges in recognizing treatment-related neuroendocrine prostate cancer. J Clin Oncol. 30:e386–e389. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Di Sant'Agnese PA and Cockett AT: The prostatic endocrine-paracrine (neuroendocrine) regulatory system and neuroendocrine differentiation in prostatic carcinoma: A review and future directions in basic research. J Urol. 152:1927–1931. 1994.PubMed/NCBI

11 

Ramírez-Balderrama L, López-Briones S, Daza-Benítez L, Macías MH, López-Gaytán T and Pérez-Vázquez V: Neuroendocrine differentiation in prostate adenocarcinoma. Gac Med Mex. 149:639–645. 2013.(In Spanish). PubMed/NCBI

12 

Kinebuchi Y, Noguchi W, Irie K, Nakayama T, Kato H and Nishizawa O: Relapsed prostate cancer with neuroendocrine differentiation and high serum levels of carcinoembryonic antigen without elevation of prostrate-specific antigen: A case report. Int J Urol. 14:147–149. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Epstein JI, Amin MB, Beltran H, Lotan TL, Mosquera JM, Reuter VE, Robinson BD, Troncoso P and Rubin MA: Proposed morphologic classification of prostate cancer with neuroendocrine differentiation. Am J Surg Pathol. 38:756–767. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Tanaka M, Suzuki Y, Takaoka K, Suzuki N, Murakami S, Matsuzaki O and Shimazaki J: Progression of prostate cancer to neuroendocrine cell tumor. Int J Urol. 8:431–437. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Marcus DM, Goodman M, Jani AB, Osunkoya AO and Rossi PJ: A comprehensive review of incidence and survival in patients with rare histological variants of prostate cancer in the United States from 1973 to 2008. Prostate Cancer Prostatic Dis. 15:283–288. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Yashi M, Terauchi F, Nukui A, Ochi M, Yuzawa M, Hara Y and Morita T: Small-cell neuroendocrine carcinoma as a variant form of prostate cancer recurrence: A case report and short literature review. Urol Oncol. 24:313–317. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Reichardt P: Systematic hormone- and chemotherapy in the management of skeletal metastases. Orthopade. 27:240–244. 1998.(In German). View Article : Google Scholar : PubMed/NCBI

18 

Lipianskaya J, Cohen A, Chen CJ, Hsia E, Squires J, Li Z, Zhang Y, Li W, Chen X, Xu H and Huang J: Androgen-deprivation therapy-induced aggressive prostate cancer with neuroendocrine differentiation. Asian J Androl. 16:541–544. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Aragon-Ching JB: The evolution of prostate cancer therapy: Targeting the androgen receptor. Front Oncol. 4:2952014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wei J, Zheng X, Li L, Wei W, Long Z and He L: Rapid progression of mixed neuroendocrine carcinoma‑acinar adenocarcinoma of the prostate: A case report. Oncol Lett 12: 1019-1022, 2016.
APA
Wei, J., Zheng, X., Li, L., Wei, W., Long, Z., & He, L. (2016). Rapid progression of mixed neuroendocrine carcinoma‑acinar adenocarcinoma of the prostate: A case report. Oncology Letters, 12, 1019-1022. https://doi.org/10.3892/ol.2016.4737
MLA
Wei, J., Zheng, X., Li, L., Wei, W., Long, Z., He, L."Rapid progression of mixed neuroendocrine carcinoma‑acinar adenocarcinoma of the prostate: A case report". Oncology Letters 12.2 (2016): 1019-1022.
Chicago
Wei, J., Zheng, X., Li, L., Wei, W., Long, Z., He, L."Rapid progression of mixed neuroendocrine carcinoma‑acinar adenocarcinoma of the prostate: A case report". Oncology Letters 12, no. 2 (2016): 1019-1022. https://doi.org/10.3892/ol.2016.4737
Copy and paste a formatted citation
x
Spandidos Publications style
Wei J, Zheng X, Li L, Wei W, Long Z and He L: Rapid progression of mixed neuroendocrine carcinoma‑acinar adenocarcinoma of the prostate: A case report. Oncol Lett 12: 1019-1022, 2016.
APA
Wei, J., Zheng, X., Li, L., Wei, W., Long, Z., & He, L. (2016). Rapid progression of mixed neuroendocrine carcinoma‑acinar adenocarcinoma of the prostate: A case report. Oncology Letters, 12, 1019-1022. https://doi.org/10.3892/ol.2016.4737
MLA
Wei, J., Zheng, X., Li, L., Wei, W., Long, Z., He, L."Rapid progression of mixed neuroendocrine carcinoma‑acinar adenocarcinoma of the prostate: A case report". Oncology Letters 12.2 (2016): 1019-1022.
Chicago
Wei, J., Zheng, X., Li, L., Wei, W., Long, Z., He, L."Rapid progression of mixed neuroendocrine carcinoma‑acinar adenocarcinoma of the prostate: A case report". Oncology Letters 12, no. 2 (2016): 1019-1022. https://doi.org/10.3892/ol.2016.4737
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