Translational significance of Nodal, Cripto-1 and Notch4 in adult nevi

Strizzi,Luigi; Margaryan,Naira  V.; Gerami,Pedram; Haghighat,Zahra; Harms,Paul  W.; Madonna,Gabriele; Botti,Gerardo; Ascierto,Paolo  A.; Hendrix,Mary J.C.

doi:10.3892/ol.2016.4755

August-2016 Volume 12 Issue 2

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August-2016 Volume 12 Issue 2

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Article Open Access

Translational significance of Nodal, Cripto-1 and Notch4 in adult nevi

Authors:
- Luigi Strizzi
- Naira V. Margaryan
- Pedram Gerami
- Zahra Haghighat
- Paul W. Harms
- Gabriele Madonna
- Gerardo Botti
- Paolo A. Ascierto
- Mary J.C. Hendrix
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Affiliations: Cancer Biology and Epigenomics Program, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA, Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA, Melanoma, Cancer Immunotherapy and Innovative Therapy Unit, Istituto Nazionale Tumori Fondazione Pascale, 80131 Napoli, Italy, Department of Pathology, Istituto Nazionale Tumori Fondazione Pascale, 80131 Napoli, Italy

Copyright: © Strizzi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 1349-1354
|
Published online on: June 21, 2016

https://doi.org/10.3892/ol.2016.4755
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Abstract

The TGF-β associated growth factor Nodal is highly expressed in aggressive metastatic melanoma. Determining the risk for melanomagenesis from Nodal expression in nevi prior to the development of melanoma may be useful for both the screening and prevention of melanoma. Tissue sections of human adult nevi with or without a history of melanoma were stained by immunohistochemistry (IHC) for Nodal, the Nodal co‑receptor Cripto-1, and Notch4, which have previously been shown to be associated with Nodal expression in melanoma. The degree of Nodal, Cripto‑1 and Notch4 staining was scored and correlated with available clinical data. Median IHC scores for Nodal, Cripto‑1 and Notch4 expression were significantly higher in nevi removed from patients who eventually developed melanoma compared with nevi from patients with no history of melanoma. In addition, the degree of Nodal expression in nevi from patients who eventually developed melanoma correlated significantly with the Breslow depth of the melanoma. Expression of Nodal and components of its signaling pathway in nevi may represent a biomarker for selecting a unique subset of patients requiring increased surveillance for screening and prevention of melanoma.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Translational significance of Nodal, Cripto-1 and Notch4 in adult nevi

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