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Article

Impact of total lesion glycolysis measured by 18F-FDG-PET/CT on overall survival and distant metastasis in hypopharyngeal cancer

  • Authors:
    • Hidenori Suzuki
    • Masami Nishio
    • Hayao Nakanishi
    • Nobuhiro Hanai
    • Hitoshi Hirakawa
    • Takeshi Kodaira
    • Tsuneo Tamaki
    • Yasuhisa Hasegawa
  • View Affiliations / Copyright

    Affiliations: Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Aichi 464‑8681, Japan, Department of Radiology, Nagoya Positron Emission Tomography Imaging Center, Nagoya, Aichi 454‑0933, Japan, Department of Pathology, Aichi Cancer Center Aichi Hospital, Okazaki, Aichi 444‑0011, Japan, Department of Radiation Oncology, Aichi Cancer Center Hospital, Nagoya, Aichi 464‑8681, Japan, Department of Radiology, East Nagoya Positron Emission Tomography Imaging Center, Nagoya, Aichi 464‑0044, Japan
  • Pages: 1493-1500
    |
    Published online on: June 23, 2016
       https://doi.org/10.3892/ol.2016.4765
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Abstract

The present study investigated the possible correlation between 18F-2-fluorodeoxyglucose (18F-FDG)-uptake parameters and clinicopathological parameters in hypopharyngeal squamous cell carcinoma (HPSCC). A total of 53 patients, newly diagnosed with HPSCC, received pretreatment 18F-FDG-positron emission tomography/computed tomography (PET/CT). Metabolic tumor volume (MTV), total lesion glycolysis (TLG), and maximum and peak standardized uptake values (SUVmax and SUVpeak) were calculated as 18F‑FDG‑uptake parameters of the primary tumor. Tumor thickness, depth of invasion and pathological tumor volume were pathologically measured. Upon univariate survival analysis, SUVmax ≥28.5, SUVpeak ≥19, MTV ≥12 and TLG ≥42 were significantly associated with a shorter overall survival (OS) time, and MTV ≥12 and TLG ≥42 were significantly associated with a shorter distant metastasis‑free survival (DMFS) time. Upon multivariate analysis with adjustment for clinical T category and treatment group, patients with SUVmax ≥28.5 exhibited a significantly shorter OS time, while TLG ≥42 was significantly correlated with shorter OS and DMFS times. Upon simple regression analysis, TLG was found to be significantly associated with tumor thickness and depth of invasion, while MTV was found to be closely associated with pathological tumor volume. In conclusion, pretreatment 18F‑FDG‑PET/CT is likely to provide valuable prognostic parameters in HPSCC.
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Copy and paste a formatted citation
Spandidos Publications style
Suzuki H, Nishio M, Nakanishi H, Hanai N, Hirakawa H, Kodaira T, Tamaki T and Hasegawa Y: Impact of total lesion glycolysis measured by 18F-FDG-PET/CT on overall survival and distant metastasis in hypopharyngeal cancer. Oncol Lett 12: 1493-1500, 2016.
APA
Suzuki, H., Nishio, M., Nakanishi, H., Hanai, N., Hirakawa, H., Kodaira, T. ... Hasegawa, Y. (2016). Impact of total lesion glycolysis measured by 18F-FDG-PET/CT on overall survival and distant metastasis in hypopharyngeal cancer. Oncology Letters, 12, 1493-1500. https://doi.org/10.3892/ol.2016.4765
MLA
Suzuki, H., Nishio, M., Nakanishi, H., Hanai, N., Hirakawa, H., Kodaira, T., Tamaki, T., Hasegawa, Y."Impact of total lesion glycolysis measured by 18F-FDG-PET/CT on overall survival and distant metastasis in hypopharyngeal cancer". Oncology Letters 12.2 (2016): 1493-1500.
Chicago
Suzuki, H., Nishio, M., Nakanishi, H., Hanai, N., Hirakawa, H., Kodaira, T., Tamaki, T., Hasegawa, Y."Impact of total lesion glycolysis measured by 18F-FDG-PET/CT on overall survival and distant metastasis in hypopharyngeal cancer". Oncology Letters 12, no. 2 (2016): 1493-1500. https://doi.org/10.3892/ol.2016.4765
Copy and paste a formatted citation
x
Spandidos Publications style
Suzuki H, Nishio M, Nakanishi H, Hanai N, Hirakawa H, Kodaira T, Tamaki T and Hasegawa Y: Impact of total lesion glycolysis measured by 18F-FDG-PET/CT on overall survival and distant metastasis in hypopharyngeal cancer. Oncol Lett 12: 1493-1500, 2016.
APA
Suzuki, H., Nishio, M., Nakanishi, H., Hanai, N., Hirakawa, H., Kodaira, T. ... Hasegawa, Y. (2016). Impact of total lesion glycolysis measured by 18F-FDG-PET/CT on overall survival and distant metastasis in hypopharyngeal cancer. Oncology Letters, 12, 1493-1500. https://doi.org/10.3892/ol.2016.4765
MLA
Suzuki, H., Nishio, M., Nakanishi, H., Hanai, N., Hirakawa, H., Kodaira, T., Tamaki, T., Hasegawa, Y."Impact of total lesion glycolysis measured by 18F-FDG-PET/CT on overall survival and distant metastasis in hypopharyngeal cancer". Oncology Letters 12.2 (2016): 1493-1500.
Chicago
Suzuki, H., Nishio, M., Nakanishi, H., Hanai, N., Hirakawa, H., Kodaira, T., Tamaki, T., Hasegawa, Y."Impact of total lesion glycolysis measured by 18F-FDG-PET/CT on overall survival and distant metastasis in hypopharyngeal cancer". Oncology Letters 12, no. 2 (2016): 1493-1500. https://doi.org/10.3892/ol.2016.4765
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