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Review

LncRNAs and cancer (Review)

  • Authors:
    • Rui Zhang
    • Li Qiong Xia
    • Wen Wen Lu
    • Jing Zhang
    • Jin‑Shui Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Shanghai Jiao Tong University Affiliated Shanghai Sixth People's Hospital, Shanghai 200233, P.R. China
  • Pages: 1233-1239
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    Published online on: June 23, 2016
       https://doi.org/10.3892/ol.2016.4770
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Abstract

Long non-coding RNAs (lncRNAs) are a group of non-coding RNAs composed of >200 nucleotides. Recent studies have revealed that lncRNAs exert an important role in the development and progression of cancer. In this review, the involvement of the most extensively investigated lncRNAs in cancers of the digestive, respiratory, reproductive, urinary and central nervous systems are discussed. LncRNAs function via molecular and biochemical mechanisms that include cis‑ and trans‑regulation of gene expression, epigenetic modulation in the nucleus and post‑transcriptional control in the cytoplasm. Although the detailed biological functions and molecular mechanisms of the majority of lncRNAs remain to be elucidated, this review aims to provide a novel insight into the diagnosis and treatment of cancer using lncRNAs.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang R, Xia LQ, Lu WW, Zhang J and Zhu JS: LncRNAs and cancer (Review). Oncol Lett 12: 1233-1239, 2016.
APA
Zhang, R., Xia, L.Q., Lu, W.W., Zhang, J., & Zhu, J. (2016). LncRNAs and cancer (Review). Oncology Letters, 12, 1233-1239. https://doi.org/10.3892/ol.2016.4770
MLA
Zhang, R., Xia, L. Q., Lu, W. W., Zhang, J., Zhu, J."LncRNAs and cancer (Review)". Oncology Letters 12.2 (2016): 1233-1239.
Chicago
Zhang, R., Xia, L. Q., Lu, W. W., Zhang, J., Zhu, J."LncRNAs and cancer (Review)". Oncology Letters 12, no. 2 (2016): 1233-1239. https://doi.org/10.3892/ol.2016.4770
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang R, Xia LQ, Lu WW, Zhang J and Zhu JS: LncRNAs and cancer (Review). Oncol Lett 12: 1233-1239, 2016.
APA
Zhang, R., Xia, L.Q., Lu, W.W., Zhang, J., & Zhu, J. (2016). LncRNAs and cancer (Review). Oncology Letters, 12, 1233-1239. https://doi.org/10.3892/ol.2016.4770
MLA
Zhang, R., Xia, L. Q., Lu, W. W., Zhang, J., Zhu, J."LncRNAs and cancer (Review)". Oncology Letters 12.2 (2016): 1233-1239.
Chicago
Zhang, R., Xia, L. Q., Lu, W. W., Zhang, J., Zhu, J."LncRNAs and cancer (Review)". Oncology Letters 12, no. 2 (2016): 1233-1239. https://doi.org/10.3892/ol.2016.4770
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