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Article Open Access

HPV16 E6 upregulates Aurora A expression

  • Authors:
    • Yi Guo
    • Jiaming Ma
    • Yahong Zheng
    • Lu Li
    • Xiaowei Gui
    • Qian Wang
    • Xiangkai Meng
    • Hong Shang
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Pain Management, Shengjing Hospital, Shenyang, Liaoning 110022, P.R. China, Key Laboratory of AIDS Immunology of Ministry of Health, Department of Laboratory Medicine, First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1387-1393
    |
    Published online on: June 27, 2016
       https://doi.org/10.3892/ol.2016.4786
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Abstract

Overexpression of Aurora A kinase occurs in certain types of cancer, and therefore results in chromosome instability and phosphorylation‑mediated ubiquitylation and degradation of p53 for tumorigenesis. The high-risk subtype human papillomavirus (HPV)16 early oncoprotein E6 is a major contributor inducing host cell immortalization and transformation through interaction with a number of cellular factors. In the present study, co‑immunoprecipitation, glutathione S-transferase pull‑down and immunostaining were used to show that HPV16 E6 and Aurora A bind to each other in vivo and in vitro. Western blotting and reverse transcription‑polymerase chain reaction were used to reveal that HPV16 E6 inhibited cell apoptosis by stabilizing Aurora A expression. The present study may report a new mechanism for the involvement of HPV16 E6 in carcinogenesis, as HPV16 E6 elevates Aurora A expression and the latter may be a common target for oncogenic viruses that result in cell carcinogenesis.
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Copy and paste a formatted citation
Spandidos Publications style
Guo Y, Ma J, Zheng Y, Li L, Gui X, Wang Q, Meng X and Shang H: HPV16 E6 upregulates Aurora A expression. Oncol Lett 12: 1387-1393, 2016.
APA
Guo, Y., Ma, J., Zheng, Y., Li, L., Gui, X., Wang, Q. ... Shang, H. (2016). HPV16 E6 upregulates Aurora A expression. Oncology Letters, 12, 1387-1393. https://doi.org/10.3892/ol.2016.4786
MLA
Guo, Y., Ma, J., Zheng, Y., Li, L., Gui, X., Wang, Q., Meng, X., Shang, H."HPV16 E6 upregulates Aurora A expression". Oncology Letters 12.2 (2016): 1387-1393.
Chicago
Guo, Y., Ma, J., Zheng, Y., Li, L., Gui, X., Wang, Q., Meng, X., Shang, H."HPV16 E6 upregulates Aurora A expression". Oncology Letters 12, no. 2 (2016): 1387-1393. https://doi.org/10.3892/ol.2016.4786
Copy and paste a formatted citation
x
Spandidos Publications style
Guo Y, Ma J, Zheng Y, Li L, Gui X, Wang Q, Meng X and Shang H: HPV16 E6 upregulates Aurora A expression. Oncol Lett 12: 1387-1393, 2016.
APA
Guo, Y., Ma, J., Zheng, Y., Li, L., Gui, X., Wang, Q. ... Shang, H. (2016). HPV16 E6 upregulates Aurora A expression. Oncology Letters, 12, 1387-1393. https://doi.org/10.3892/ol.2016.4786
MLA
Guo, Y., Ma, J., Zheng, Y., Li, L., Gui, X., Wang, Q., Meng, X., Shang, H."HPV16 E6 upregulates Aurora A expression". Oncology Letters 12.2 (2016): 1387-1393.
Chicago
Guo, Y., Ma, J., Zheng, Y., Li, L., Gui, X., Wang, Q., Meng, X., Shang, H."HPV16 E6 upregulates Aurora A expression". Oncology Letters 12, no. 2 (2016): 1387-1393. https://doi.org/10.3892/ol.2016.4786
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