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Article

Aloe-emodin suppresses esophageal cancer cell TE1 proliferation by inhibiting AKT and ERK phosphorylation

  • Authors:
    • Xiaobin Chang
    • Jimin Zhao
    • Fang Tian
    • Yanan Jiang
    • Jing Lu
    • Junfen Ma
    • Xiaoyan Zhang
    • Guoguo Jin
    • Youtian Huang
    • Zigang Dong
    • Kangdong Liu
    • Ziming Dong
  • View Affiliations / Copyright

    Affiliations: Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China
  • Pages: 2232-2238
    |
    Published online on: July 25, 2016
       https://doi.org/10.3892/ol.2016.4910
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Abstract

Aberrant AKT and extracellular signal-regulated kinase (ERK) activation is often observed in various human cancers. Both AKT and ERK are important in the phosphoinositide 3-kinase/AKT and mitogen-activated protein kinase kinase/ERK signaling pathways, which play vital roles in cell proliferation, differentiation and survival. Compounds that are able to block these pathways have therefore a promising use in cancer treatment and prevention. The present study revealed that AKT and ERK are activated in esophageal cancer TE1 cells. Aloe‑emodin, an anthraquinone present in aloe latex, can suppress TE1 cell proliferation and anchor‑independent cell growth. Aloe‑emodin can also reduce the number of TE1 cells in S phase. Protein analysis indicated that aloe‑emodin inhibits the phosphorylation of AKT and ERK in a dose‑dependent manner. Overall, the present data indicate that aloe‑emodin can suppress TE1 cell growth by inhibiting AKT and ERK phosphorylation, and suggest its clinical use for cancer therapy.
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1 

Ghasemi-Kebria F, Roshandel G, Semnani S, Shakeri R, Khoshnia M, Naeimi-Tabiei M, Merat S and Malekzadeh R: Marked increase in the incidence rate of esophageal adenocarcinoma in a high-risk area for esophageal cancer. Arch Iran Med. 16:320–323. 2013.PubMed/NCBI

2 

Zhang XM and Guo MZ: The value of epigenetic markers in esophageal cancer. Front Med China. 4:378–384. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Pohl H, Sirovich B and Welch HG: Esophageal adenocarcinoma incidence: Are we reaching the peak? Cancer Epidemiol Biomarkers Prev. 19:1468–1470. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Siegel R, Naishadham D and Jemal A: Cancer statistics for Hispanics/Latinos, 2012. CA Cancer J Clin. 62:283–298. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Pennathur A, Gibson MK, Jobe BA and Luketich JD: Oesophageal carcinoma. Lancet. 381:400–412. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Pennathur A, Farkas A, Krasinskas AM, Ferson PF, Gooding WE, Gibson MK, Schuchert MJ, Landreneau RJ and Luketich JD: Esophagectomy for T1 esophageal cancer: Outcomes in 100 patients and implications for endoscopic therapy. Ann Thorac Surg. 87:1048–1054; discussion 1054–1055. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Akagi I, Miyashita M, Makino H, Nomura T, Hagiwara N, Takahashi K, Cho K, Mishima T, Ishibashi O, Ushijima T, et al: Overexpression of PIK3CA is associated with lymph node metastasis in esophageal squamous cell carcinoma. Int J Oncol. 34:767–775. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Okines A, Cunningham D and Chau I: Targeting the human EGFR family in esophagogastric cancer. Nat Rev Clin Oncol. 8:492–503. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Bettstetter M, Berezowska S, Keller G, Walch A, Feuchtinger A, Slotta-Huspenina J, Feith M, Drecoll E, Höfler H and Langer R: Epidermal growth factor receptor, phosphatidylinositol-3-kinase catalytic subunit/PTEN, and KRAS/NRAS/BRAF in primary resected esophageal adenocarcinomas: Loss of PTEN is associated with worse clinical outcome. Hum Pathol. 44:829–836. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Hou G, Lu Z, Liu M, Liu H and Xue L: Mutational analysis of the PTEN gene and its effects in esophageal squamous cell carcinoma. Dig Dis Sci. 56:1315–1322. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Cho MY, Kim HS, Eng C, Kim DS, Kang SJ, Eom M, Yi SY and Bronner MP: First report of ovarian dysgerminoma in Cowden syndrome with germline PTEN mutation and PTEN-related 10q loss of tumor heterozygosity. Am J Surg Pathol. 32:1258–1264. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Lugli A, Zlobec I, Minoo P, Tornillo L, Terracciano L and Jass JR: Role of the mitogen-activated protein kinase and phosphoinositide 3-kinase/AKT pathways downstream molecules, phosphorylated extracellular signal-regulated kinase, and phosphorylated AKT in colorectal cancer - a tissue microarray-based approach. Hum Pathol. 37:1022–1031. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Kocieniewski P and Lipniacki T: MEK1 and MEK2 differentially control the duration and amplitude of the ERK cascade response. Phys Biol. 10:0350062013. View Article : Google Scholar : PubMed/NCBI

15 

Chappell WH, Steelman LS, Long JM, Kempf RC, Abrams SL, Franklin RA, Bäsecke J, Stivala F, Donia M, Fagone P, et al: Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: Rationale and importance to inhibiting these pathways in human health. Oncotarget. 2:135–164. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Mebratu Y and Tesfaigzi Y: How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer? Cell Cycle. 8:1168–1175. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Santarpia L, Lippman SM and El-Naggar AK: Targeting the MAPK-RAS-RAF signaling pathway in cancer therapy. Expert Opin Ther Targets. 16:103–119. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Martelli AM, Tabellini G, Bressanin D, Ognibene A, Goto K, Cocco L and Evangelisti C: The emerging multiple roles of nuclear Akt. Biochim Biophys Acta. 1823:2168–2178. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Li XY, Zhan XR, Liu XM and Wang XC: CREB is a regulatory target for the protein kinase Akt/PKB in the differentiation of pancreatic ductal cells into islet β-cells mediated by hepatocyte growth factor. Biochem Biophys Res Commun. 404:711–716. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Du K and Montminy M: CREB is a regulatory target for the protein kinase Akt/PKB. J Biol Chem. 273:32377–32379. 1998. View Article : Google Scholar : PubMed/NCBI

21 

Nicholson KM and Anderson NG: The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal. 14:381–395. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Wang JM, Chao JR, Chen W, Kuo ML, Yen JJ and Yang-Yen HF: The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB. Mol Cell Biol. 19:6195–6206. 1999. View Article : Google Scholar : PubMed/NCBI

23 

Feng J, Tamaskovic R, Yang Z, Brazil DP, Merlo A, Hess D and Hemmings BA: Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation. J Biol Chem. 279:35510–35517. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Zhou BP, Liao Y, Xia W, Spohn B, Lee MH and Hung MC: Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat Cell Biol. 3:245–252. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Diehl JA, Cheng M, Roussel MF and Sherr CJ: Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev. 12:3499–3511. 1998. View Article : Google Scholar : PubMed/NCBI

26 

Gregory MA, Qi Y and Hann SR: Phosphorylation by glycogen synthase kinase-3 controls c-myc proteolysis and subnuclear localization. J Biol Chem. 278:51606–51612. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Popadic D, Savic E, Ramic Z, Djordjevic V, Trajkovic V, Medenica L and Popadic S: Aloe-emodin inhibits proliferation of adult human keratinocytes in vitro. J Cosmet Sci. 63:297–302. 2012.PubMed/NCBI

28 

Tabolacci C, Oliverio S, Lentini A, Rossi S, Galbiati A, Montesano C, Mattioli P, Provenzano B, Facchiano F and Beninati S: Aloe-emodin as antiproliferative and differentiating agent on human U937 monoblastic leukemia cells. Life Sci. 89:812–820. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Suboj P, Babykutty S, Srinivas P and Gopala S: Aloe emodin induces G2/M cell cycle arrest and apoptosis via activation of caspase-6 in human colon cancer cells. Pharmacology. 89:91–98. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Radovic J, Maksimovic-Ivanic D, Timotijevic G, Popadic S, Ramic Z, Trajkovic V, Miljkovic D, Stosic-Grujicic S and Mijatovic S: Cell-type dependent response of melanoma cells to aloe emodin. Food Chem Toxicol. 50:3181–3189. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Pecere T, Gazzola MV, Mucignat C, Parolin C, Vecchia FD, Cavaggioni A, Basso G, Diaspro A, Salvato B, Carli M and Palù G: Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors. Cancer Res. 60:2800–2804. 2000.PubMed/NCBI

32 

Lin ML, Lu YC, Chung JG, Li YC, Wang SGNGSH, Wu CY, Su HL and Chen SS: Aloe-emodin induces apoptosis of human nasopharyngeal carcinoma cells via caspase-8-mediated activation of the mitochondrial death pathway. Cancer Lett. 291:46–58. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Lee HZ: Protein kinase C involvement in aloe-emodin- and emodin-induced apoptosis in lung carcinoma cell. Br J Pharmacol. 134:1093–1103. 2001. View Article : Google Scholar : PubMed/NCBI

34 

Kuo PL, Lin TC and Lin CC: The antiproliferative activity of aloe-emodin is through p53-dependent and p21-dependent apoptotic pathway in human hepatoma cell lines. Life Sci. 71:1879–1892. 2002. View Article : Google Scholar : PubMed/NCBI

35 

Guo J, Xiao B, Zhang S, Liu D, Liao Y and Sun Q: Growth inhibitory effects of gastric cancer cells with an increase in S phase and alkaline phosphatase activity repression by aloe-emodin. Cancer Biol Ther. 6:85–88. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Liu K, Park C, Li S, Lee KW, Liu H, He L, Soung NK, Ahn JS, Bode AM, Dong Z, et al: Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2. Carcinogenesis. 33:1406–1411. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Lu GD, Shen HM, Chung MC and Ong CN: Critical role of oxidative stress and sustained JNK activation in aloe-emodin-mediated apoptotic cell death in human hepatoma cells. Carcinogenesis. 28:1937–1945. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Chiu TH, Lai WW, Hsia TC, Yang JS, Lai TY, Wu PP, Ma CY, Yeh CC, Ho CC, Lu HF, et al: Aloe-emodin induces cell death through S-phase arrest and caspase-dependent pathways in human tongue squamous cancer SCC-4 cells. Anticancer Res. 29:4503–4511. 2009.PubMed/NCBI

39 

Wang ZW, Wang JS, Yang MH, Luo JG and Kong LY: Developmental Changes in the composition of five anthraquinones from rheum palmatum as quantified by (1) H-NMR. Phytochem Anal. 24:329–335. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Di Luccia B, Manzo N, Vivo M, Galano E, Amoresano A, Crescenzi E, Pollice A, Tudisco R, Infascelli F and Calabrò V: A biochemical and cellular approach to explore the antiproliferative and prodifferentiative activity of Aloe arborescens leaf extract. Phytother Res. 27:1819–1828. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Albanese C, Johnson J, Watanabe G, Eklund N, Vu D, Arnold A and Pestell RG: Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions. J Biol Chem. 270:23589–23597. 1995. View Article : Google Scholar : PubMed/NCBI

42 

Guo J, Xiao B, Liu Q, Gong Z and Le Y: Suppression of C-myc expression associates with anti-proliferation of aloe-emodin on gastric cancer cells. Cancer Invest. 26:369–374. 2008. View Article : Google Scholar : PubMed/NCBI

43 

Suboj P, Babykutty S, Valiyaparambil Gopi DR, Nair RS, Srinivas P and Gopala S: Aloe emodin inhibits colon cancer cell migration/angiogenesis by downregulating MMP-2/9, RhoB and VEGF via reduced DNA binding activity of NF-κB. Eur J Pharm Sci. 45:581–591. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Shimura T: Acquired radioresistance of cancer and the AKT/GSK3β/cyclin D1 overexpression cycle. J Radiat Res. 52:539–544. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Fonar Y and Frank D: FAK and WNT signaling: The meeting of two pathways in cancer and development. Anticancer Agents Med Chem. 11:600–606. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Xia P and Xu XY: PI3K/Akt/mTOR signaling pathway in cancer stem cells: From basic research to clinical application. Am J Cancer Res. 5:1602–1609. 2015.PubMed/NCBI

47 

Steelman LS, Chappell WH, Abrams SL, Kempf RC, Long J, Laidler P, Mijatovic S, Maksimovic-Ivanic D, Stivala F, Mazzarino MC, et al: Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging. Aging (Albany NY). 3:192–222. 2011. View Article : Google Scholar : PubMed/NCBI

48 

Shigaki H, Baba Y, Watanabe M, Murata A, Ishimoto T, Iwatsuki M, Iwagami S, Nosho K and Baba H: PIK3CA mutation is associated with a favorable prognosis among patients with curatively resected esophageal squamous cell carcinoma. Clin Cancer Res. 19:2451–2459. 2013. View Article : Google Scholar : PubMed/NCBI

49 

Roberts PJ and Der CJ: Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene. 26:3291–3310. 2007. View Article : Google Scholar : PubMed/NCBI

50 

Acevedo-Duncan M, Russell C, Patel S and Patel R: Aloe-emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells. Int Immunopharmacol. 4:1775–1784. 2004. View Article : Google Scholar : PubMed/NCBI

51 

Jeon W, Jeon YK and Nam MJ: Apoptosis by aloe-emodin is mediated through down-regulation of calpain-2 and ubiquitin-protein ligase E3A in human hepatoma Huh-7 cells. Cell Biol Int. 36:163–167. 2012. View Article : Google Scholar : PubMed/NCBI

52 

Guo JM, Xiao BX, Liu Q, Zhang S, Liu DH and Gong ZH: Anticancer effect of aloe-emodin on cervical cancer cells involves G2/M arrest and induction of differentiation. Acta Pharmacol Sin. 28:1991–1995. 2007. View Article : Google Scholar : PubMed/NCBI

53 

Lin HJ, Chao PD, Huang SY, Wan L, Wu CJ and Tsai FJ: Aloe-emodin suppressed NMDA-induced apoptosis of retinal ganglion cells through regulation of ERK phosphorylation. Phytother Res. 21:1007–1014. 2007. View Article : Google Scholar : PubMed/NCBI

54 

Mijatovic S, Maksimovic-Ivanic D, Radovic J, Miljkovic Dj, Harhaji Lj, Vuckovic O, Stosic-Grujicic S, Stojkovic Mostarica M and Trajkovic V: Anti-glioma action of aloe emodin: The role of ERK inhibition. Cell Mol Life Sci. 62:589–598. 2005. View Article : Google Scholar : PubMed/NCBI

55 

Selvaraj N, Budka JA, Ferris MW, Jerde TJ and Hollenhorst PC: Prostate cancer ETS rearrangements switch a cell migration gene expression program from RAS/ERK to PI3K/AKT regulation. Mol Cancer. 13:612014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chang X, Zhao J, Tian F, Jiang Y, Lu J, Ma J, Zhang X, Jin G, Huang Y, Dong Z, Dong Z, et al: Aloe-emodin suppresses esophageal cancer cell TE1 proliferation by inhibiting AKT and ERK phosphorylation. Oncol Lett 12: 2232-2238, 2016.
APA
Chang, X., Zhao, J., Tian, F., Jiang, Y., Lu, J., Ma, J. ... Dong, Z. (2016). Aloe-emodin suppresses esophageal cancer cell TE1 proliferation by inhibiting AKT and ERK phosphorylation. Oncology Letters, 12, 2232-2238. https://doi.org/10.3892/ol.2016.4910
MLA
Chang, X., Zhao, J., Tian, F., Jiang, Y., Lu, J., Ma, J., Zhang, X., Jin, G., Huang, Y., Dong, Z., Liu, K., Dong, Z."Aloe-emodin suppresses esophageal cancer cell TE1 proliferation by inhibiting AKT and ERK phosphorylation". Oncology Letters 12.3 (2016): 2232-2238.
Chicago
Chang, X., Zhao, J., Tian, F., Jiang, Y., Lu, J., Ma, J., Zhang, X., Jin, G., Huang, Y., Dong, Z., Liu, K., Dong, Z."Aloe-emodin suppresses esophageal cancer cell TE1 proliferation by inhibiting AKT and ERK phosphorylation". Oncology Letters 12, no. 3 (2016): 2232-2238. https://doi.org/10.3892/ol.2016.4910
Copy and paste a formatted citation
x
Spandidos Publications style
Chang X, Zhao J, Tian F, Jiang Y, Lu J, Ma J, Zhang X, Jin G, Huang Y, Dong Z, Dong Z, et al: Aloe-emodin suppresses esophageal cancer cell TE1 proliferation by inhibiting AKT and ERK phosphorylation. Oncol Lett 12: 2232-2238, 2016.
APA
Chang, X., Zhao, J., Tian, F., Jiang, Y., Lu, J., Ma, J. ... Dong, Z. (2016). Aloe-emodin suppresses esophageal cancer cell TE1 proliferation by inhibiting AKT and ERK phosphorylation. Oncology Letters, 12, 2232-2238. https://doi.org/10.3892/ol.2016.4910
MLA
Chang, X., Zhao, J., Tian, F., Jiang, Y., Lu, J., Ma, J., Zhang, X., Jin, G., Huang, Y., Dong, Z., Liu, K., Dong, Z."Aloe-emodin suppresses esophageal cancer cell TE1 proliferation by inhibiting AKT and ERK phosphorylation". Oncology Letters 12.3 (2016): 2232-2238.
Chicago
Chang, X., Zhao, J., Tian, F., Jiang, Y., Lu, J., Ma, J., Zhang, X., Jin, G., Huang, Y., Dong, Z., Liu, K., Dong, Z."Aloe-emodin suppresses esophageal cancer cell TE1 proliferation by inhibiting AKT and ERK phosphorylation". Oncology Letters 12, no. 3 (2016): 2232-2238. https://doi.org/10.3892/ol.2016.4910
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