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Aspirin inhibits the proliferation and migration of gastric cancer cells in p53-knockout mice

  • Authors:
    • Xue-Fu Li
    • Bing-Zhong Xu
    • Shi-Zhen Wang
  • View Affiliations / Copyright

    Affiliations: Department of Anatomy, Jiangsu Vocational College of Nursing, Huaian, Jiangsu 223300, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3183-3186
    |
    Published online on: August 30, 2016
       https://doi.org/10.3892/ol.2016.5067
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Abstract

The aim of the present study was to investigate the effect of aspirin on the cell proliferation and migration of gastric cancer cells in p53-knockout mice. Twenty p53-/- male mice aged 6 to 7 weeks, with an average weight of 20±3 g were used. The model of gastric cancer was established by the implantation of a mouse forestomach carcinoma cell line, subcutaneously, at the back of the neck, and then the mice were randomly divided into two groups after establishment of the model (control group, n=10; experimental group, n=10). Aspirin (250 mg/kg) was added to the food in the experimental group one day before model establishment, until the end of the experiment. Mice in the control group were given regular food without aspirin. All mice were sacrificed 3 months afterwards, and gastric cancer tissues were harvested. MTT assay was used to detect the proliferation of the tumor cells. Tumor cell number was also observed. Migration ability was detected by scratch assay, and E-cadherin protein expression was evaluated by immunofluorescence. The results revealed that the proliferation ability of tumor cells in the experimental group was lower than that in the control group. In addition, cell numbers were significantly decreased and the migration ability was diminished. The expression of E-cadherin was also increased in the experimental group, and the differences were statistically significant (P<0.05). In conclusion, aspirin inhibited the cell proliferation and migration of gastric cancer cells in mice.
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1 

Soon S, Chia WJ, Redekop K and Wee HL: A cost-effectiveness analysis of aspirin in the primary prevention of cardiovascular diseases and colorectal cancer. Value Health. 18:A4622015. View Article : Google Scholar : PubMed/NCBI

2 

Wilson LF, Green AC, Kendall BJ, Jordan SJ, Nagle CM, Bain CJ, Neale RE and Whiteman DC: Cancers prevented in Australia in 2010 through the consumption of aspirin. Aust NZ J Public Health. 39:414–417. 2015. View Article : Google Scholar

3 

Wright JL, Chéry L, Holt S, Lin DW, Luedeke M, Rinckleb AE, Maier C and Stanford JL: Aspirin and NSAID use in association with molecular subtypes of prostate cancer defined by TMPRSS2: ERG fusion status. Prostate Cancer Prostatic Dis. 19:53–56. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Mikami J, Kurokawa Y, Takahashi T, Miyazaki Y, Yamasaki M, Miyata H, Nakajima K, Takiguchi S, Mori M and Doki Y: Antitumor effect of antiplatelet agents in gastric cancer cells: an in vivo and in vitro study. Gastric Cancer. Oct 20–2015.(Epub ahead of print).

5 

Zhang YP, Wan YD, Sun YL, Li J and Zhu RT: Aspirin might reduce the incidence of pancreatic cancer: a meta-analysis of observational studies. Sci Rep. 5:154602015. View Article : Google Scholar : PubMed/NCBI

6 

Wan L, Dong H, Xu H, Ma J, Zhu Y, Lu Y, Wang J, Zhang T, Li T, Xie J, et al: Aspirin, lysine, mifepristone and doxycycline combined can effectively and safely prevent and treat cancer metastasis: prevent seeds from gemmating on soil. Oncotarget. 6:35157–35172. 2015.PubMed/NCBI

7 

Gonzalez-Gonzalez M, Garcia J, Alcazar JA, Gutierrez ML, Gonzalez LM, Bengoechea O, Abad MM, Santos-Briz A, Blanco O, Martin M, Rodriguez A, Fuentes M, Munoz-Bellvis L, Orfao A and Sayagues JM: Association between the cytogenetic profile of tumor cells and response to preoperative radiochemotherapy in locally advanced rectal cancer. Medicine (Baltimore). 93:e1532014. View Article : Google Scholar : PubMed/NCBI

8 

Fontana E, Smyth EC, Cunningham D, Rao S, Watkins D, Allum WH, Thompson J, Waddell T, Peckitt C, Chau I, et al: Improved survival in resected oesophageal and gastric adenocarcinomas over a decade: the Royal Marsden experience 2001–2010. Gastric Cancer. Nov 5–2015.(Epub ahead of print). PubMed/NCBI

9 

Gu Q, Zhang J, Hu H, Tan YE, Shi S and Nian Y: Clinical significance of MiR-137 expression in patients with gastric cancer after radical gastrectomy. PLos One. 10:e01423772015. View Article : Google Scholar : PubMed/NCBI

10 

Sugimura T and Fujimura S: Tumour production in glandular stomach of rat by N-methyl-N'-nitro-N-nitrosoguanidine. Nature. 216:943–944. 1967. View Article : Google Scholar : PubMed/NCBI

11 

Thompson J, Epting T, Schwarzkopf G, Singhofen A, Eades-Perner AM, van Der Putten H and Zimmermann W: A transgenic mouse line that develops early-onset invasive gastric carcinoma provides a model for carcinoembryonic antigen-targeted tumor therapy. Int J Cancer. 86:863–869. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Furukawa H, Iwanaga T, Nakajima T, Okabayashi K, Nakazato H, Hiratsuka M, Ohta K, Kito T, Yamamura Y and Goto S: Randomized study with mitomycin C + 5-fluorouracil+cytosine arabinoside (MFC)+5-fluorouracil, MFC+tegafur and uracil (UFT), and MF+UFT in advanced gastric cancer: interinstitutional differences in a multicenter study in Japan. J Surg Oncol. 60:59–64. 1995. View Article : Google Scholar : PubMed/NCBI

13 

Logan RF, Grainge MJ, Shepherd VC, Armitage NC and Muir KR: ukCAP Trial Group: Aspirin and folic acid for the prevention of recurrent colorectal adenomas. Gastroenterology. 134:29–38. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Osborn VW, Chen SC, Weiner J, Schwartz D and Schreiber D: Impact of aspirin on clinical outcomes for African American men with prostate cancer undergoing radiation. Tumori. 102:65–70. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Huang WK, Tu HT and See LC: Aspirin use on incidence and mortality of gastrointestinal cancers: current state of epidemiological evidence. Curr Pharm Des. 21:5108–5115. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Di Francesco L, López Contreras LA, Sacco A and Patrignani P: New insights into the mechanism of action of aspirin in the prevention of colorectal neoplasia. Curr Pharm Des. 21:5116–5126. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Kraus S, Sion D and Arber N: Can we select patients for colorectal cancer prevention with aspirin? Curr Pharm Des. 21:5127–5134. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Kastrati I, Litosh VA, Zhao S, Alvarez M, Thatcher GR and Frasor J: A novel aspirin prodrug inhibits NFκB activity and breast cancer stem cell properties. BMC Cancer. 15:8452015. View Article : Google Scholar : PubMed/NCBI

19 

Cheng GZ, Zhang W and Wang LH: Regulation of cancer cell survival, migration, and invasion by Twist: AKT2 comes to interplay. Cancer Res. 68:957–960. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Qin Y, Tang B, Hu CJ, Xiao YF, Xie R, Yong X, Wu YY, Dong H and Yang SM: An hTERT/ZEB1 complex directly regulates E-cadherin to promote epithelial-to-mesenchymal transition (EMT) in colorectal cancer. Oncotarget. 7:351–361. 2016.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li X, Xu B and Wang S: Aspirin inhibits the proliferation and migration of gastric cancer cells in p53-knockout mice. Oncol Lett 12: 3183-3186, 2016.
APA
Li, X., Xu, B., & Wang, S. (2016). Aspirin inhibits the proliferation and migration of gastric cancer cells in p53-knockout mice. Oncology Letters, 12, 3183-3186. https://doi.org/10.3892/ol.2016.5067
MLA
Li, X., Xu, B., Wang, S."Aspirin inhibits the proliferation and migration of gastric cancer cells in p53-knockout mice". Oncology Letters 12.5 (2016): 3183-3186.
Chicago
Li, X., Xu, B., Wang, S."Aspirin inhibits the proliferation and migration of gastric cancer cells in p53-knockout mice". Oncology Letters 12, no. 5 (2016): 3183-3186. https://doi.org/10.3892/ol.2016.5067
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Xu B and Wang S: Aspirin inhibits the proliferation and migration of gastric cancer cells in p53-knockout mice. Oncol Lett 12: 3183-3186, 2016.
APA
Li, X., Xu, B., & Wang, S. (2016). Aspirin inhibits the proliferation and migration of gastric cancer cells in p53-knockout mice. Oncology Letters, 12, 3183-3186. https://doi.org/10.3892/ol.2016.5067
MLA
Li, X., Xu, B., Wang, S."Aspirin inhibits the proliferation and migration of gastric cancer cells in p53-knockout mice". Oncology Letters 12.5 (2016): 3183-3186.
Chicago
Li, X., Xu, B., Wang, S."Aspirin inhibits the proliferation and migration of gastric cancer cells in p53-knockout mice". Oncology Letters 12, no. 5 (2016): 3183-3186. https://doi.org/10.3892/ol.2016.5067
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