Management of pediatric head and neck rhabdomyosarcoma: A case-series of 36 patients

  • Authors:
    • Joanna Radzikowska
    • Wojciech Kukwa
    • Andrzej Kukwa
    • Anna M. Czarnecka
    • Maciej Kawecki
    • Fei Lian
    • Cezary Szczylik
    • Antoni Krzeski
  • View Affiliations

  • Published online on: September 1, 2016     https://doi.org/10.3892/ol.2016.5072
  • Pages: 3555-3562
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Abstract

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in the pediatric population. In 35% of cases, RMS develops in the head and neck (H&N) region, and only combined therapy is recognized as a curative treatment. However, recent advances in skull base and reconstructive surgery, along with microsurgery and endoscopic surgery, have strengthened the role of surgery as an important part of RMS treatment. In the present study, 36 pediatric RMS cases (24 males and 12 females) were analyzed after surgical treatment. The average age at diagnosis was 7 years. In total, 67% of tumors were localized in the parameningeal region. Alveolar RMS was the most common histopathological type. A total of 16 patients were treated due to disease recurrence or a previous non‑radical surgical procedure, while 19 cases had inductive chemotherapy and/or radiotherapy preceding surgical treatment due to locally advanced disease. In 1 case, only diagnostic biopsy was performed. It is recommended that the management of H&N RMS is interdisciplinary from the beginning. Extensive surgical dissection in the H&N region for RMS may result in severe cosmetic defects and functional impairment; thus, these risks should be considered during treatment planning, and the surgical approach should be based on the individual characteristics of each patient.
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November-2016
Volume 12 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Radzikowska J, Kukwa W, Kukwa A, Czarnecka AM, Kawecki M, Lian F, Szczylik C and Krzeski A: Management of pediatric head and neck rhabdomyosarcoma: A case-series of 36 patients. Oncol Lett 12: 3555-3562, 2016
APA
Radzikowska, J., Kukwa, W., Kukwa, A., Czarnecka, A.M., Kawecki, M., Lian, F. ... Krzeski, A. (2016). Management of pediatric head and neck rhabdomyosarcoma: A case-series of 36 patients. Oncology Letters, 12, 3555-3562. https://doi.org/10.3892/ol.2016.5072
MLA
Radzikowska, J., Kukwa, W., Kukwa, A., Czarnecka, A. M., Kawecki, M., Lian, F., Szczylik, C., Krzeski, A."Management of pediatric head and neck rhabdomyosarcoma: A case-series of 36 patients". Oncology Letters 12.5 (2016): 3555-3562.
Chicago
Radzikowska, J., Kukwa, W., Kukwa, A., Czarnecka, A. M., Kawecki, M., Lian, F., Szczylik, C., Krzeski, A."Management of pediatric head and neck rhabdomyosarcoma: A case-series of 36 patients". Oncology Letters 12, no. 5 (2016): 3555-3562. https://doi.org/10.3892/ol.2016.5072