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Article Open Access

The targetable role of herpes virus-associated ubiquitin-specific protease (HAUSP) in p190 BCR-ABL leukemia

  • Authors:
    • Giovanna Carrà
    • Cristina Panuzzo
    • Sabrina Crivellaro
    • Deborah Morena
    • Riccardo Taulli
    • Angelo Guerrasio
    • Giuseppe Saglio
    • Alessandro Morotti

  • View Affiliations / Copyright

    Affiliations: Department of Clinical and Biological Sciences, ‘San Luigi Gonzaga’ University Hospital, School of Medicine, University of Turin, 10043 Turin, Italy, Department of Oncology, ‘San Luigi Gonzaga’ University Hospital, School of Medicine, University of Turin, 10043 Turin, Italy
    Copyright: © Carrà et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3123-3126
    |
    Published online on: September 1, 2016
       https://doi.org/10.3892/ol.2016.5073
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Abstract

Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) is driven by the p190 breakpoint cluster region (BCR)‑ABL isoform. Although effectively targeted by BCR‑ABL tyrosine kinase inhibitors (TKIs), ALL is associated with a less effective response to TKIs compared with chronic myeloid leukemia. Therefore, the identification of additional genes required for ALL maintenance may provide possible therapeutic targets to aid the eradication of this cancer. The present study demonstrated that p190 BCR‑ABL is able to interact with the deubiquitinase herpesvirus‑associated ubiquitin‑specific protease (HAUSP), which in turn affects p53 protein stability. Notably, the inhibition of HAUSP with small molecule inhibitors promoted the upregulation of p53 protein levels. These results suggest that HAUSP inhibitors may harbor clinically relevant implications in the treatment of Ph+ ALL.
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Copy and paste a formatted citation
Spandidos Publications style
Carrà G, Panuzzo C, Crivellaro S, Morena D, Taulli R, Guerrasio A, Saglio G and Morotti A: The targetable role of herpes virus-associated ubiquitin-specific protease (HAUSP) in p190 BCR-ABL leukemia. Oncol Lett 12: 3123-3126, 2016.
APA
Carrà, G., Panuzzo, C., Crivellaro, S., Morena, D., Taulli, R., Guerrasio, A. ... Morotti, A. (2016). The targetable role of herpes virus-associated ubiquitin-specific protease (HAUSP) in p190 BCR-ABL leukemia. Oncology Letters, 12, 3123-3126. https://doi.org/10.3892/ol.2016.5073
MLA
Carrà, G., Panuzzo, C., Crivellaro, S., Morena, D., Taulli, R., Guerrasio, A., Saglio, G., Morotti, A."The targetable role of herpes virus-associated ubiquitin-specific protease (HAUSP) in p190 BCR-ABL leukemia". Oncology Letters 12.5 (2016): 3123-3126.
Chicago
Carrà, G., Panuzzo, C., Crivellaro, S., Morena, D., Taulli, R., Guerrasio, A., Saglio, G., Morotti, A."The targetable role of herpes virus-associated ubiquitin-specific protease (HAUSP) in p190 BCR-ABL leukemia". Oncology Letters 12, no. 5 (2016): 3123-3126. https://doi.org/10.3892/ol.2016.5073
Copy and paste a formatted citation
x
Spandidos Publications style
Carrà G, Panuzzo C, Crivellaro S, Morena D, Taulli R, Guerrasio A, Saglio G and Morotti A: The targetable role of herpes virus-associated ubiquitin-specific protease (HAUSP) in p190 BCR-ABL leukemia. Oncol Lett 12: 3123-3126, 2016.
APA
Carrà, G., Panuzzo, C., Crivellaro, S., Morena, D., Taulli, R., Guerrasio, A. ... Morotti, A. (2016). The targetable role of herpes virus-associated ubiquitin-specific protease (HAUSP) in p190 BCR-ABL leukemia. Oncology Letters, 12, 3123-3126. https://doi.org/10.3892/ol.2016.5073
MLA
Carrà, G., Panuzzo, C., Crivellaro, S., Morena, D., Taulli, R., Guerrasio, A., Saglio, G., Morotti, A."The targetable role of herpes virus-associated ubiquitin-specific protease (HAUSP) in p190 BCR-ABL leukemia". Oncology Letters 12.5 (2016): 3123-3126.
Chicago
Carrà, G., Panuzzo, C., Crivellaro, S., Morena, D., Taulli, R., Guerrasio, A., Saglio, G., Morotti, A."The targetable role of herpes virus-associated ubiquitin-specific protease (HAUSP) in p190 BCR-ABL leukemia". Oncology Letters 12, no. 5 (2016): 3123-3126. https://doi.org/10.3892/ol.2016.5073
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