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Article Open Access

Tumor-penetration and antitumor efficacy of cetuximab are enhanced by co-administered iRGD in a murine model of human NSCLC

  • Authors:
    • Yang Zhang
    • Jie Yang
    • Manhua Ding
    • Liantao Li
    • Zheng Lu
    • Qing Zhang
    • Junnian Zheng
  • View Affiliations / Copyright

    Affiliations: Cancer Institute, Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China, Department of Oncology, Xuzhou Tumor Hospital, Xuzhou, Jiangsu 221005, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3241-3249
    |
    Published online on: September 2, 2016
       https://doi.org/10.3892/ol.2016.5081
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Abstract

Lung cancer is the leading cause of cancer‑associated mortality, worldwide. For this reason, novel therapies are required for the treatment of this devastating disease. Cetuximab is a monoclonal antibody against epidermal growth factor receptor (EGFR), which is overexpressed in a variety of solid tumors, including non‑small cell lung cancer (NSCLC). The therapeutic efficacy of cetuximab for NSCLC is limited to use as a monotherapy or in combination with chemotherapy. The objective of the present study was to develop a novel strategy to enhance the therapeutic efficacy of cetuximab for NSCLC by a co‑administration with the tumor‑penetrating internalizing RGD peptide (iRGD). Human NSCLC subcutaneous xenograft models established with the A549 cell line in nude mice were treated with 30 mg/kg cetuximab, 4 mg/kg iRGD, cetuximab plus iRGD or phosphate‑buffered saline. The tumor‑penetration, in vivo therapeutic efficacy and involved mechanism were evaluated. The present study showed that the A549 xenograft model is sensitive to the co-administration of cetuximab and iRGD. Treatment with cetuximab plus iRGD resulted in a significant increase in the tumor‑penetration of cetuximab and tumor reduction compared with cetuximab monotherapy. In conclusion, iRGD enhances the effects of co‑administered cetuximab in an NSCLC model. The combined application of cetuximab and iRGD may be a novel strategy to enhance the clinical therapeutic efficacy of cetuximab for the treatment of NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Yang J, Ding M, Li L, Lu Z, Zhang Q and Zheng J: Tumor-penetration and antitumor efficacy of cetuximab are enhanced by co-administered iRGD in a murine model of human NSCLC. Oncol Lett 12: 3241-3249, 2016.
APA
Zhang, Y., Yang, J., Ding, M., Li, L., Lu, Z., Zhang, Q., & Zheng, J. (2016). Tumor-penetration and antitumor efficacy of cetuximab are enhanced by co-administered iRGD in a murine model of human NSCLC. Oncology Letters, 12, 3241-3249. https://doi.org/10.3892/ol.2016.5081
MLA
Zhang, Y., Yang, J., Ding, M., Li, L., Lu, Z., Zhang, Q., Zheng, J."Tumor-penetration and antitumor efficacy of cetuximab are enhanced by co-administered iRGD in a murine model of human NSCLC". Oncology Letters 12.5 (2016): 3241-3249.
Chicago
Zhang, Y., Yang, J., Ding, M., Li, L., Lu, Z., Zhang, Q., Zheng, J."Tumor-penetration and antitumor efficacy of cetuximab are enhanced by co-administered iRGD in a murine model of human NSCLC". Oncology Letters 12, no. 5 (2016): 3241-3249. https://doi.org/10.3892/ol.2016.5081
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Yang J, Ding M, Li L, Lu Z, Zhang Q and Zheng J: Tumor-penetration and antitumor efficacy of cetuximab are enhanced by co-administered iRGD in a murine model of human NSCLC. Oncol Lett 12: 3241-3249, 2016.
APA
Zhang, Y., Yang, J., Ding, M., Li, L., Lu, Z., Zhang, Q., & Zheng, J. (2016). Tumor-penetration and antitumor efficacy of cetuximab are enhanced by co-administered iRGD in a murine model of human NSCLC. Oncology Letters, 12, 3241-3249. https://doi.org/10.3892/ol.2016.5081
MLA
Zhang, Y., Yang, J., Ding, M., Li, L., Lu, Z., Zhang, Q., Zheng, J."Tumor-penetration and antitumor efficacy of cetuximab are enhanced by co-administered iRGD in a murine model of human NSCLC". Oncology Letters 12.5 (2016): 3241-3249.
Chicago
Zhang, Y., Yang, J., Ding, M., Li, L., Lu, Z., Zhang, Q., Zheng, J."Tumor-penetration and antitumor efficacy of cetuximab are enhanced by co-administered iRGD in a murine model of human NSCLC". Oncology Letters 12, no. 5 (2016): 3241-3249. https://doi.org/10.3892/ol.2016.5081
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