miR-520e regulates cell proliferation, apoptosis and migration in breast cancer

  • Authors:
    • Ming Yi
    • Minghua Li
    • Xia Long
    • Jing Ye
    • Junwei Cui
    • Wei Wei
    • Huijuan Wan
    • Meijun Yin
    • Shuying Gao
    • Zhengming Su
    • Fangting Zhang
  • View Affiliations

  • Published online on: September 5, 2016     https://doi.org/10.3892/ol.2016.5085
  • Pages: 3543-3548
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Abstract

Previous studies have indicated that the deregulation of microRNAs contributes to tumorigenesis. Misregulation of microRNA-520e (miR-520e) has been observed in various types of cancer. However, the expression profile and biological function of miR-520e in breast cancer remains largely unknown. The present study demonstrated that miR‑520e expression was significantly increased in breast cancer tissues compared with adjacent non‑cancerous breast tissues in 21 patients, as revealed by reverse transcription-quantitative polymerase chain reaction. Furthermore, the proliferation capacity of breast cancer cells was markedly enhanced by the introduction of miR‑520e in vitro using a cell counting kit‑8 assay. The present study also revealed that the overexpression of miR‑520e could suppress breast cancer cell apoptosis, revealed using Annexin V/propidium iodide double staining and flow cytometry analysis. In addition, the ectopic expression of miR‑520e promoted the migration of breast cancer cells in vitro, as demonstrated by a Transwell assay. Overall, the findings of the present study highlight an important role for miR‑520e in breast cancer development and in the molecular etiology of breast cancer, which indicates the potential application of miR‑520e in cancer therapy.
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November-2016
Volume 12 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Yi M, Li M, Long X, Ye J, Cui J, Wei W, Wan H, Yin M, Gao S, Su Z, Su Z, et al: miR-520e regulates cell proliferation, apoptosis and migration in breast cancer. Oncol Lett 12: 3543-3548, 2016
APA
Yi, M., Li, M., Long, X., Ye, J., Cui, J., Wei, W. ... Zhang, F. (2016). miR-520e regulates cell proliferation, apoptosis and migration in breast cancer. Oncology Letters, 12, 3543-3548. https://doi.org/10.3892/ol.2016.5085
MLA
Yi, M., Li, M., Long, X., Ye, J., Cui, J., Wei, W., Wan, H., Yin, M., Gao, S., Su, Z., Zhang, F."miR-520e regulates cell proliferation, apoptosis and migration in breast cancer". Oncology Letters 12.5 (2016): 3543-3548.
Chicago
Yi, M., Li, M., Long, X., Ye, J., Cui, J., Wei, W., Wan, H., Yin, M., Gao, S., Su, Z., Zhang, F."miR-520e regulates cell proliferation, apoptosis and migration in breast cancer". Oncology Letters 12, no. 5 (2016): 3543-3548. https://doi.org/10.3892/ol.2016.5085