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Article

Clinical implication of Tiam1 overexpression in the prognosis of patients with serous ovarian carcinoma

  • Authors:
    • Huiwen Li
    • Xuelian Cui
    • Dingbao Chen
    • Yang Yang
    • Junjie Piao
    • Zhenhua Lin
    • Guanghai Yan
    • Danhua Shen
  • View Affiliations / Copyright

    Affiliations: Cancer Research Center, Yanbian University, Yanji, Jilin 133002, P.R. China, Department of Pathology, The People's Hospital of Beijing University, Beijing 100044, P.R. China
  • Pages: 3492-3498
    |
    Published online on: September 5, 2016
       https://doi.org/10.3892/ol.2016.5091
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Abstract

T lymphoma invasion and metastasis 1 (Tiam1), a guanine nucleotide exchange factor, was originally identified as an invasion- and metastasis-inducing gene in T lymphoma cells. High expression levels of the human Tiam1 gene have been found in numerous human malignancies, suggesting a potential role as a modifier of tumor initiation and progression. However, little is known about the status of Tiam1 in ovarian carcinoma. The present study aimed to investigate the clinicopathological significance of high Tiam1 expression in serous ovarian carcinoma. Immunohistochemical staining for Tiam1 was performed in 182 patients with serous ovarian carcinoma, in 76 patients with ovarian borderline tumors and in 72 patients with benign ovarian tumors. Immunofluorescence staining was also performed to detect the subcellular localization of Tiam1 protein in SK‑OV‑3 ovarian carcinoma cells. The correlations between high Tiam1 expression and the clinicopathological features of the ovarian carcinomas were evaluated by the χ2 test and Fisher's exact test. The overall survival (OS) rates were calculated by the Kaplan‑Meier method, and the association between prognostic factors and patient survival was analyzed by the Cox proportional hazard model. Tiam1 protein showed a cytoplasmic and nuclear staining pattern in ovarian carcinoma. Strongly‑positive Tiam1 protein expression was observed in 59.3% (108/182) of ovarian carcinomas, which was significantly higher than in benign serous tumors (12.5%; 9/72). Moreover, the rate of strongly‑positive Tiam1 expression in borderline serous tumors (31.6%; 24/76) was also significantly higher than that in benign serous tumors. High Tiam1 protein expression was closely associated with a high histological grade, metastasis, advanced clinical stage and lower OS rates in ovarian carcinoma. Multivariate analysis indicated that Tiam1 was an independent prognostic factor, along with metastasis and clinical stage, in patients with ovarian carcinoma. In conclusion, Tiam1 expression is strongly associated with grade and outcome in ovarian carcinoma, and may serve as a useful molecular marker for clinical management.
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1 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Smolle E, Taucher V, Pichler M, Petru E, Lax S and Haybaeck J: Targeting signaling pathways in epithelial ovarian cancer. Int J Mol Sci. 14:9536–9555. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Habets GG, Scholtes EH, Zuydgeest D, van der Kammen RA, Stam JC, Berns A and Collard JG: Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins. Cell. 77:537–549. 1994. View Article : Google Scholar : PubMed/NCBI

4 

Habets GG, van der Kammen RA, Stam JC, Michiels F and Collard JG: Sequence of the human invasion-inducing TIAM1 gene, its conservation in evolution and its expression in tumor cell lines of different tissue origin. Oncogene. 10:1371–1376. 1995.PubMed/NCBI

5 

Hordijk PL, ten Klooster JP, van der Kammen RA, Michiels F, Oomen LC and Collard JG: Inhibition of invasion of epithelial cells by Tiam1-Rac signaling. Science. 278:1464–1466. 1997. View Article : Google Scholar : PubMed/NCBI

6 

Michiels F, Habets GG, Stam JC, van der Kammen RA and Collard JG: A role for Rac in Tiam1-induced membrane ruffling and invasion. Nature. 375:338–340. 1995. View Article : Google Scholar : PubMed/NCBI

7 

Mertens AE, Roovers RC and Collard JG: Regulation of Tiam1-Rac signalling. FEBS Lett. 546:11–16. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Bollag G, Crompton AM, Peverly-Mitchell D, Habets GG and Symons M: Activation of Rac1 by human Tiam1. Methods Enzymol. 325:51–61. 2000. View Article : Google Scholar : PubMed/NCBI

9 

Matsuo N, Terao M, Nabeshima Y and Hoshino M: Roles of STEF/Tiam1, guanine nucleotide exchange factors for Rac1, in regulation of growthcone morphology. Mol Cell Neurosci. 24:69–81. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Du X, Wang S, Lu J, Wang Q, Song N, Yang T, Dong R, Zang L, Yang Y, Wu T and Wang C: Clinical value of Tiam1-Rac1 signaling in primary gallbladder carcinoma. Med Oncol. 29:1873–1878. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Qi Y, Huang B, Yu L, Wang Q, Lan G and Zhang Q: Prognostic value of Tiam1 and Rac1 overexpression in nasopharyngeal carcinoma. ORLJ Otorhinolaryngol Relat Spec. 71:163–171. 2009. View Article : Google Scholar

12 

Xu K, Rajagopal S, Klebba I, Dong S, Ji Y, Liu J, Kuperwasser C, Garlick JA, Naber SP and Buchsbaum RJ: The role of fibroblast Tiam1 in tumor cell invasion and metastasis. Oncogene. 29:6533–6542. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Malliri A, van der Kammen RA, Clark K, van der Valk M, Michiels F and Collard JG: Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours. Nature. 417:867–871. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Adam L, Vadlamudi RK, McCrea P and Kumar R: Tiam1 overexpression potentiates heregulin-induced lymphoid enhancer factor-1/beta-catenin nuclear signaling in breast cancer cells by modulating the intercellular stability. J Biol Chem. 276:28443–28450. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Minard ME, Ellis LM and Gallick GE: Tiam1 regulates cell adhesion, migration and apoptosis in colon tumor cells. Clin Exp Metastasis. 23:301–313. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Engers R, Mueller M, Walter A, Collard JG, Willers R and Gabbert HE: Prognostic relevance of Tiam1 protein expression in prostate carcinomas. Br J Cancer. 95:1081–1086. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Huang J, Ye X, Guan J, Chen B, Li Q, Zheng X, Liu L, Wang S, Ding Y, Ding Y and Chen L: Tiam1 is associated with hepatocellular carcinoma metastasis. Int J Cancer. 132:90–100. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Liu H, Shi G, Liu X, Wu H, Fan Q and Wang X: Overexpression of Tiam1 predicts poor prognosis in patients with esophageal squamous cell carcinoma. Oncol Rep. 25:841–848. 2011.PubMed/NCBI

19 

Wang H, Wang H, Makki MS, Wen J, Dai Y, Shi Q, Liu Q, Zhou X and Wang J: Overexpression of β-catenin and cyclinD1 predicts a poor prognosis in ovarian serous carcinomas. Int J Clin Exp Pathol. 7:264–271. 2013.PubMed/NCBI

20 

Cui X, Li L, Yan G, Meng K, Lin Z, Nan Y, Jin G and Li C: High expression of NQO1 is associated with poor prognosis in serous ovarian carcinoma. BMC Cancer. 15:2442015. View Article : Google Scholar : PubMed/NCBI

21 

Ma Y, Kong J, Yan G, Ren X, Jin D, Jin T, Lin L and Lin Z: NQO1 overexpression is associated with poor prognosis in squamous cell carcinoma of the uterine cervix. BMC Cancer. 14:4142014. View Article : Google Scholar : PubMed/NCBI

22 

Liu S, Li Y, Qi W, Zhao Y, Huang A, Sheng W, Lei B, Lin P, Zhu H, Li W and Shen H: Expression of Tiam1 predicts lymph node metastasis and poor survival of lung adenocarcinoma patients. Diagn Pathol. 9:692014. View Article : Google Scholar : PubMed/NCBI

23 

Sander EE, van Delft S, ten Klooster JP, Reid T, van der Kammen RA, Michiels F and Collard JG: Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase. J Cell Biol. 143:1385–1398. 1998. View Article : Google Scholar : PubMed/NCBI

24 

Sander EE, ten Klooster JP, van Delft S, van der Kammen RA and Collard JG: Rac downregulates Rho activity: Reciprocal balance between both GTPases determines cellular morphology and migratory behavior. J Cell Biol. 147:1009–1022. 1999. View Article : Google Scholar : PubMed/NCBI

25 

Boissier P and Huynh-Do U: The guanine nucleotide exchange factor Tiam1: A Janus-faced molecule in cellular signaling. Cell Signal. 26:483–491. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Yu LN, Zhang QL, Li X, Hua X, Cui YM, Zhang NJ, Liao WT and Ding YQ: Tiam1 transgenic mice display increased tumor invasive and metastatic potential of colorectal cancer after 1,2-dimethylhydrazine treatment. PLoS One. 8:e730772013. View Article : Google Scholar : PubMed/NCBI

27 

Li J, Liang S, Jin H, Xu C, Ma D and Lu X: Tiam1, negatively regulated by miR-22, miR-183 and miR-31, is involved in migration, invasion and viability of ovarian cancer cells. Oncol Rep. 27:1835–1842. 2012.PubMed/NCBI

28 

Kurman RJ and le M Shih: Pathogenesis of ovarian cancer: Lessons from morphology and molecular biology and their clinical implications. Int J Gynecol Pathol. 27:151–160. 2008.PubMed/NCBI

29 

Yang W, Lv S, Liu X, Liu H, Yang W and Hu F: Up-regulation of Tiam1 and Rac1 correlates with poor prognosis in hepatocellular carcinoma. Jpn J Clin Oncol. 40:1053–1059. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li H, Cui X, Chen D, Yang Y, Piao J, Lin Z, Yan G and Shen D: Clinical implication of Tiam1 overexpression in the prognosis of patients with serous ovarian carcinoma. Oncol Lett 12: 3492-3498, 2016.
APA
Li, H., Cui, X., Chen, D., Yang, Y., Piao, J., Lin, Z. ... Shen, D. (2016). Clinical implication of Tiam1 overexpression in the prognosis of patients with serous ovarian carcinoma. Oncology Letters, 12, 3492-3498. https://doi.org/10.3892/ol.2016.5091
MLA
Li, H., Cui, X., Chen, D., Yang, Y., Piao, J., Lin, Z., Yan, G., Shen, D."Clinical implication of Tiam1 overexpression in the prognosis of patients with serous ovarian carcinoma". Oncology Letters 12.5 (2016): 3492-3498.
Chicago
Li, H., Cui, X., Chen, D., Yang, Y., Piao, J., Lin, Z., Yan, G., Shen, D."Clinical implication of Tiam1 overexpression in the prognosis of patients with serous ovarian carcinoma". Oncology Letters 12, no. 5 (2016): 3492-3498. https://doi.org/10.3892/ol.2016.5091
Copy and paste a formatted citation
x
Spandidos Publications style
Li H, Cui X, Chen D, Yang Y, Piao J, Lin Z, Yan G and Shen D: Clinical implication of Tiam1 overexpression in the prognosis of patients with serous ovarian carcinoma. Oncol Lett 12: 3492-3498, 2016.
APA
Li, H., Cui, X., Chen, D., Yang, Y., Piao, J., Lin, Z. ... Shen, D. (2016). Clinical implication of Tiam1 overexpression in the prognosis of patients with serous ovarian carcinoma. Oncology Letters, 12, 3492-3498. https://doi.org/10.3892/ol.2016.5091
MLA
Li, H., Cui, X., Chen, D., Yang, Y., Piao, J., Lin, Z., Yan, G., Shen, D."Clinical implication of Tiam1 overexpression in the prognosis of patients with serous ovarian carcinoma". Oncology Letters 12.5 (2016): 3492-3498.
Chicago
Li, H., Cui, X., Chen, D., Yang, Y., Piao, J., Lin, Z., Yan, G., Shen, D."Clinical implication of Tiam1 overexpression in the prognosis of patients with serous ovarian carcinoma". Oncology Letters 12, no. 5 (2016): 3492-3498. https://doi.org/10.3892/ol.2016.5091
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