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Article

Expression of aldehyde dehydrogenase family 1 member A1 and high mobility group box 1 in oropharyngeal squamous cell carcinoma in association with survival time

  • Authors:
    • Xu Qian
    • Annekatrin Coordes
    • Andreas M. Kaufmann
    • Andreas E. Albers
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, Head and Neck Surgery, Charité ‑ Medical University of Berlin, Benjamin Franklin Campus, D‑12200 Berlin, Germany, Clinic for Gynecology, Charité ‑ Medical University of Berlin, Benjamin Franklin Campus, D‑12200 Berlin, Germany
  • Pages: 3429-3434
    |
    Published online on: September 7, 2016
       https://doi.org/10.3892/ol.2016.5100
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Abstract

Despite the development of novel multimodal treatment combinations in advanced oropharyngeal squamous cell carcinoma (OSCC), outcomes remain poor. The identification of specifically validated biomarkers is required to understand the underlying molecular mechanisms, to evaluate treatment efficiency and to develop novel therapeutic targets. The present study, therefore, examined the presence of aldehyde dehydrogenase family 1 member A1 (ALDH1A1) and high mobility group box 1 (HMGB1) expression in primary OSCC and analyzed the impact on survival time. In 59 patients with OSCC, the expression of ALDH1A1, p16 and HMGB1, and their clinicopathological data were analyzed. HMGB1 positivity was significantly increased in patients with T1‑2 stage disease compared with T3‑4 stage disease (P<0.001), whereas ALDH1A1 positivity was not. ALDH1A1+ tumors showed significantly lower differentiation than ALDH1A1‑ tumors (P=0.018). Multivariate analysis showed that ALDH1A1 positivity (P=0.041) and nodal status (N2‑3) (P=0.036) predicted a poor prognosis. In this patient cohort, ALDH1A1 and nodal status were identified as independent predictors of a shorter overall survival time. The study results, therefore, provide evidence of the prognostic value of ALDH1A1 as a marker for cancer stem cells and nodal status in OSCC patients.
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1 

Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin. 55:74–108. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T and Thun MJ: Cancer statistics, 2008. CA Cancer J Clin. 58:71–96. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Gibson MK and Forastiere AA: Multidisciplinary approaches in the management of advanced head and neck tumors: State of the art. Curr Opin Oncol. 16:220–224. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Leemans CR, Braakhuis BJ and Brakenhoff RH: The molecular biology of head and neck cancer. Nat Rev Cancer. 11:9–22. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Albers AE, Chen C, Köberle B, Qian X, Klussmann JP, Wollenberg B and Kaufmann AM: Stem cells in squamous head and neck cancer. Crit Rev Oncol Hematol. 81:224–240. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Bustin M, Lehn DA and Landsman D: Structural features of the HMG chromosomal proteins and their genes. Biochim Biophys Acta. 1049:231–243. 1990. View Article : Google Scholar : PubMed/NCBI

8 

Kang R, Chen R, Zhang Q, Hou W, Wu S, Cao L, Huang J, Yu Y, Fan XG, Yan Z, et al: HMGB1 in health and disease. Mol Aspects Med. 40:1–116. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Wang WK, Lu QH, Zhang JN, Wang B, Liu XJ, An FS, Qin WD, Chen XY, Dong WQ, Zhang C, et al: HMGB1 mediates hyperglycaemia-induced cardiomyocyte apoptosis via ERK/Ets-1 signalling pathway. J Cell Mol Med. 18:2311–2320. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Liu S, Stolz DB, Sappington PL, Macias CA, Killeen ME, Tenhunen JJ, Delude RL and Fink MP: HMGB1 is secreted by immunostimulated enterocytes and contributes to cytomix-induced hyperpermeability of Caco-2 monolayers. Am J Physiol Cell Physiol. 290:C990–C999. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Wang H, Vishnubhakat JM, Bloom O, Zhang M, Ombrellino M, Sama A and Tracey KJ: Proinflammatory cytokines (tumor necrosis factor and interleukin 1) stimulate release of high mobility group protein-1 by pituicytes. Surgery. 126:389–392. 1999. View Article : Google Scholar : PubMed/NCBI

12 

Kim NG, Choi YR, Baek MJ, Kim YH, Kang H, Kim NK, Min JS and Kim H: Frameshift mutations at coding mononucleotide repeats of the hRAD50 gene in gastrointestinal carcinomas with microsatellite instability. Cancer Res. 61:36–38. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Yang S, Xu L, Yang T and Wang F: High-mobility group box-1 and its role in angiogenesis. J Leukoc Biol. 95:563–574. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Kang R, Tang D, Schapiro NE, Loux T, Livesey KM, Billiar TR, Wang H, Van Houten B, Lotze MT and Zeh HJ: The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergetics. Oncogene. 33:567–577. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Qiu Y, Chen Y, Fu X, Zhang L, Tian J and Hao Q: HMGB1 promotes lymphangiogenesis of human lymphatic endothelial cells in vitro. Med Oncol. 29:358–363. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Sims GP, Rowe DC, Rietdijk ST, Herbst R and Coyle AJ: HMGB1 and RAGE in inflammation and cancer. Annu Rev Immunol. 28:367–388. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Choi J, Lee MK, Oh KH, Kim YS, Choi HY, Baek SK, Jung KY, Woo JS, Lee SH and Kwon SY: Interaction effect between the receptor for advanced glycation end products (RAGE) and high-mobility group box-1 (HMGB-1) for the migration of a squamous cell carcinoma cell line. Tumori. 97:196–202. 2011.PubMed/NCBI

18 

Mittal D, Saccheri F, Venereau E, Pusterla T, Bianchi ME and Rescigno M: TLR4-mediated skin carcinogenesis is dependent on immune and radioresistant cells. EMBO J. 29:2242–2252. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Yu LX, Yan L, Yang W, Wu FQ, Ling Y, Chen SZ, Tang L, Tan YX, Cao D, Wu MC, et al: Platelets promote tumour metastasis via interaction between TLR4 and tumour cell-released high-mobility group box 1 protein. Nat Commun. 5:52562014. View Article : Google Scholar : PubMed/NCBI

20 

Wild CA, Brandau S, Lotfi R, Mattheis S, Gu X, Lang S and Bergmann C: HMGB1 is overexpressed in tumor cells and promotes activity of regulatory T cells in patients with head and neck cancer. Oral Oncol. 48:409–416. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Qiu G, Li Y, Liu Z, Wang M, Ge J and Bai X: Clinical value of serum HMGB1 in diagnosis and prognosis of laryngeal squamous cell carcinoma. Med Oncol. 31:3162014. View Article : Google Scholar : PubMed/NCBI

22 

Liu Y, Xie C, Zhang X, Huang D, Zhou X, Tan P, Qi L, Hu G, Tian Y and Qiu Y: Elevated expression of HMGB1 in squamous-cell carcinoma of the head and neck and its clinical significance. Eur J Cancer. 46:3007–3015. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Chen C, Wei Y, Hummel M, Hoffmann TK, Gross M, Kaufmann AM and Albers AE: Evidence for epithelial-mesenchymal transition in cancer stem cells of head and neck squamous cell carcinoma. PloS One. 6:e164662011. View Article : Google Scholar : PubMed/NCBI

24 

Liao T, Kaufmann AM, Qian X, Sangvatanakul V, Chen C, Kube T, Zhang G and Albers AE: Susceptibility to cytotoxic T cell lysis of cancer stem cells derived from cervical and head and neck tumor cell lines. J Cancer Res Clin Oncol. 139:159–170. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Qian X, Wagner S, Ma C, Coordes A, Gekeler J, Klussmann JP, Hummel M, Kaufmann AM and Albers AE: Prognostic significance of ALDH1A1-positive cancer stem cells in patients with locally advanced, metastasized head and neck squamous cell carcinoma. J Cancer Res Clin Oncol. 140:1151–1158. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Qian X, Wagner S, Ma C, Klussmann JP, Hummel M, Kaufmann AM and Albers AE: ALDH1-positive cancer stem-like cells are enriched in nodal metastases of oropharyngeal squamous cell carcinoma independent of HPV status. Oncol Rep. 29:1777–1784. 2013.PubMed/NCBI

27 

Hanakawa H, Orita Y, Sato Y, Takeuchi M, Takao S, Ohno K, Kohno T, Iwaki N, Marunaka H, Tamamura R, et al: Does HMGB1 predict occult neck lymph node metastasis in early tongue carcinoma? A case-control study of 26 patients. J Laryngol Otol. 128:926–931. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Cardesa A and Slootweg PJ: Pathology of the Head and Neck. 1st. Springer-Verlag; Heidelberg: pp. 142006

29 

Rainsbury JW, Ahmed W, Williams HK, Roberts S, Paleri V and Mehanna H: Prognostic biomarkers of survival in oropharyngeal squamous cell carcinoma: Systematic review and meta-analysis. Head Neck. 35:1048–1055. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Zuo Z, Che X, Wang Y, Li B, Li J, Dai W, Lin CP and Huang C: High mobility group Box-1 inhibits cancer cell motility and metastasis by suppressing activation of transcription factor CREB and nWASP expression. Oncotarget. 5:7458–7470. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Jiao Y, Wang HC and Fan SJ: Growth suppression and radiosensitivity increase by HMGB1 in breast cancer. Acta Pharmacol Sin. 28:1957–1967. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Zhou C and Sun B: The prognostic role of the cancer stem cell marker aldehyde dehydrogenase 1 in head and neck squamous cell carcinomas: A meta-analysis. Oral Oncol. 50:1144–1148. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Qian X, Ma C, Nie X, Lu J, Lenarz M, Kaufmann AM and Albers AE: Biology and immunology of cancer stem (−like) cells in head and neck cancer. Crit Rev Oncol Hematol. 95:337–345. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Chen M, Liu Y, Varley P, Chang Y, He XX, Huang H, Tang D, Lotze MT, Lin J and Tsung A: High-mobility group box 1 promotes hepatocellular carcinoma progression through miR-21-mediated matrix metalloproteinase activity. Cancer Res. 75:1645–1656. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Sun Z, Li S, Kaufmann AM and Albers AE: miR-21 increases the programmed cell death 4 gene-regulated cell proliferation in head and neck squamous carcinoma cell lines. Oncol Rep. 32:2283–2289. 2014.PubMed/NCBI

36 

Hammarstedt L, Lindquist D, Dahlstrand H, Romanitan M, Dahlgren LO, Joneberg J, Creson N, Lindholm J, Ye W, Dalianis T and Munck-Wikland E: Human papillomavirus as a risk factor for the increase in incidence of tonsillar cancer. Int J Cancer. 119:2620–2623. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Tinhofer I, Jöhrens K, Keilholz U, Kaufmann A, Lehmann A, Weichert W, Stenzinger A, Stromberger C, Klinghammer K, Becker ET, et al: Contribution of human papilloma virus to the incidence of squamous cell carcinoma of the head and neck in a European population with high smoking prevalence. Eur J Cancer. 51:514–521. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Ang KK, Harris J, Wheeler R, Weber R, Rosenthal DI, Nguyen-Tân PF, Westra WH, Chung CH, Jordan RC, Lu C, et al: Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med. 363:24–35. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Qian X, Coordes A, Kaufmann AM and Albers AE: Expression of aldehyde dehydrogenase family 1 member A1 and high mobility group box 1 in oropharyngeal squamous cell carcinoma in association with survival time. Oncol Lett 12: 3429-3434, 2016.
APA
Qian, X., Coordes, A., Kaufmann, A.M., & Albers, A.E. (2016). Expression of aldehyde dehydrogenase family 1 member A1 and high mobility group box 1 in oropharyngeal squamous cell carcinoma in association with survival time. Oncology Letters, 12, 3429-3434. https://doi.org/10.3892/ol.2016.5100
MLA
Qian, X., Coordes, A., Kaufmann, A. M., Albers, A. E."Expression of aldehyde dehydrogenase family 1 member A1 and high mobility group box 1 in oropharyngeal squamous cell carcinoma in association with survival time". Oncology Letters 12.5 (2016): 3429-3434.
Chicago
Qian, X., Coordes, A., Kaufmann, A. M., Albers, A. E."Expression of aldehyde dehydrogenase family 1 member A1 and high mobility group box 1 in oropharyngeal squamous cell carcinoma in association with survival time". Oncology Letters 12, no. 5 (2016): 3429-3434. https://doi.org/10.3892/ol.2016.5100
Copy and paste a formatted citation
x
Spandidos Publications style
Qian X, Coordes A, Kaufmann AM and Albers AE: Expression of aldehyde dehydrogenase family 1 member A1 and high mobility group box 1 in oropharyngeal squamous cell carcinoma in association with survival time. Oncol Lett 12: 3429-3434, 2016.
APA
Qian, X., Coordes, A., Kaufmann, A.M., & Albers, A.E. (2016). Expression of aldehyde dehydrogenase family 1 member A1 and high mobility group box 1 in oropharyngeal squamous cell carcinoma in association with survival time. Oncology Letters, 12, 3429-3434. https://doi.org/10.3892/ol.2016.5100
MLA
Qian, X., Coordes, A., Kaufmann, A. M., Albers, A. E."Expression of aldehyde dehydrogenase family 1 member A1 and high mobility group box 1 in oropharyngeal squamous cell carcinoma in association with survival time". Oncology Letters 12.5 (2016): 3429-3434.
Chicago
Qian, X., Coordes, A., Kaufmann, A. M., Albers, A. E."Expression of aldehyde dehydrogenase family 1 member A1 and high mobility group box 1 in oropharyngeal squamous cell carcinoma in association with survival time". Oncology Letters 12, no. 5 (2016): 3429-3434. https://doi.org/10.3892/ol.2016.5100
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