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Low extracellular lysyl oxidase expression is associated with poor prognosis in patients with prostate cancer

  • Authors:
    • Wei Zheng
    • Xuejian Wang
    • Qiwei Chen
    • Kun Fang
    • Lina Wang
    • Feng Chen
    • Xiancheng Li
    • Ziyao Li
    • Jianbo Wang
    • Yingxi Liu
    • Deyong Yang
    • Xishuang Song
  • View Affiliations / Copyright

    Affiliations: Department of Urology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China, Department of Biomedical Engineering, Dalian University of Technology, Dalian, Liaoning 116024, P.R. China
    Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3161-3166
    |
    Published online on: September 12, 2016
       https://doi.org/10.3892/ol.2016.5118
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Abstract

Remodeling of the extracellular matrix (ECM), which is induced by lysyl oxidase (LOX), has been demonstrated to accompany tumor progression; however, the association between LOX expression levels and the malignant behavior of prostate cancer (Pca) remains unclear. The present study aimed to analyze the tumor‑associated expression profile of LOX in patients with Pca and to evaluate its potential prognostic value. In the form of a retrospective study, the expression patterns of LOX and collagen I were analyzed in patients with benign prostate hyperplasia and Pca by immunohistochemical examination. The results demonstrated that, with the initiation and progression of Pca, the expression levels of LOX and collagen I were closely associated with Gleason score and tumor stage. In addition, although LOX was expressed in cancer and non‑cancer tissues, the differential expression pattern observed in the ECM of Pca cells may indicate that LOX is an important molecule that affects the progression of this disease. Therefore, LOX expression level in the ECM may function as an independent predictor of Pca.
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Copy and paste a formatted citation
Spandidos Publications style
Zheng W, Wang X, Chen Q, Fang K, Wang L, Chen F, Li X, Li Z, Wang J, Liu Y, Liu Y, et al: Low extracellular lysyl oxidase expression is associated with poor prognosis in patients with prostate cancer. Oncol Lett 12: 3161-3166, 2016.
APA
Zheng, W., Wang, X., Chen, Q., Fang, K., Wang, L., Chen, F. ... Song, X. (2016). Low extracellular lysyl oxidase expression is associated with poor prognosis in patients with prostate cancer. Oncology Letters, 12, 3161-3166. https://doi.org/10.3892/ol.2016.5118
MLA
Zheng, W., Wang, X., Chen, Q., Fang, K., Wang, L., Chen, F., Li, X., Li, Z., Wang, J., Liu, Y., Yang, D., Song, X."Low extracellular lysyl oxidase expression is associated with poor prognosis in patients with prostate cancer". Oncology Letters 12.5 (2016): 3161-3166.
Chicago
Zheng, W., Wang, X., Chen, Q., Fang, K., Wang, L., Chen, F., Li, X., Li, Z., Wang, J., Liu, Y., Yang, D., Song, X."Low extracellular lysyl oxidase expression is associated with poor prognosis in patients with prostate cancer". Oncology Letters 12, no. 5 (2016): 3161-3166. https://doi.org/10.3892/ol.2016.5118
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng W, Wang X, Chen Q, Fang K, Wang L, Chen F, Li X, Li Z, Wang J, Liu Y, Liu Y, et al: Low extracellular lysyl oxidase expression is associated with poor prognosis in patients with prostate cancer. Oncol Lett 12: 3161-3166, 2016.
APA
Zheng, W., Wang, X., Chen, Q., Fang, K., Wang, L., Chen, F. ... Song, X. (2016). Low extracellular lysyl oxidase expression is associated with poor prognosis in patients with prostate cancer. Oncology Letters, 12, 3161-3166. https://doi.org/10.3892/ol.2016.5118
MLA
Zheng, W., Wang, X., Chen, Q., Fang, K., Wang, L., Chen, F., Li, X., Li, Z., Wang, J., Liu, Y., Yang, D., Song, X."Low extracellular lysyl oxidase expression is associated with poor prognosis in patients with prostate cancer". Oncology Letters 12.5 (2016): 3161-3166.
Chicago
Zheng, W., Wang, X., Chen, Q., Fang, K., Wang, L., Chen, F., Li, X., Li, Z., Wang, J., Liu, Y., Yang, D., Song, X."Low extracellular lysyl oxidase expression is associated with poor prognosis in patients with prostate cancer". Oncology Letters 12, no. 5 (2016): 3161-3166. https://doi.org/10.3892/ol.2016.5118
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