ETS‑related gene is a novel prognostic factor in childhood acute lymphoblastic leukemia

  • Authors:
    • Hai‑Zhao Zhao
    • Ming Jia
    • Ze‑Bin Luo
    • Xiao‑Jun Xu
    • Si‑Si Li
    • Jing‑Ying Zhang
    • Xiao‑Ping Guo
    • Yong‑Min Tang
  • View Affiliations

  • Published online on: November 18, 2016     https://doi.org/10.3892/ol.2016.5397
  • Pages: 455-462
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Abstract

The ETS‑related gene (ERG) has been demonstrated to be associated with overall survival in cytogenetically normal acute myeloid leukemia and acute T cell‑lymphoblastic leukemia (T‑ALL) in adult patients. However, there are no data available regarding the impact of ERG expression on childhood ALL. In the present study, ERG expression levels were analyzed in bone marrow samples from 119 ALL pediatric patients. ALL patients demonstrated higher ERG expression compared with the controls (P<0.0001). In addition, low ERG expression identified a group of patients with higher white blood cell counts (P=0.011), higher percentages of T‑ALL immunophenotype (P=0.027), and higher relapse rates (P=0.009). Survival analyses demonstrated that low ERG expression was associated with inferior relapse‑free survival (RFS) in childhood ALL (P=0.036) and was an independent prognostic factor in multivariable analyses for RFS. In conclusion, low ERG expression is associated with poor outcomes and may be used to serve as a molecular prognostic marker to identify patients with a high risk of relapse in childhood ALL.
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January-2017
Volume 13 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhao HZ, Jia M, Luo ZB, Xu XJ, Li SS, Zhang JY, Guo XP and Tang YM: ETS‑related gene is a novel prognostic factor in childhood acute lymphoblastic leukemia. Oncol Lett 13: 455-462, 2017
APA
Zhao, H., Jia, M., Luo, Z., Xu, X., Li, S., Zhang, J. ... Tang, Y. (2017). ETS‑related gene is a novel prognostic factor in childhood acute lymphoblastic leukemia. Oncology Letters, 13, 455-462. https://doi.org/10.3892/ol.2016.5397
MLA
Zhao, H., Jia, M., Luo, Z., Xu, X., Li, S., Zhang, J., Guo, X., Tang, Y."ETS‑related gene is a novel prognostic factor in childhood acute lymphoblastic leukemia". Oncology Letters 13.1 (2017): 455-462.
Chicago
Zhao, H., Jia, M., Luo, Z., Xu, X., Li, S., Zhang, J., Guo, X., Tang, Y."ETS‑related gene is a novel prognostic factor in childhood acute lymphoblastic leukemia". Oncology Letters 13, no. 1 (2017): 455-462. https://doi.org/10.3892/ol.2016.5397