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Article

miR-506 suppresses neuroblastoma metastasis by targeting ROCK1

  • Authors:
    • Dianguo Li
    • Yanhua Cao
    • Jinliang Li
    • Jialong Xu
    • Qian Liu
    • Xiaogang Sun
  • View Affiliations / Copyright

    Affiliations: Department of Pediatric Surgery, Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China, Department of Pediatrics, General Hospital of Jinan Command, Jinan, Shandong 250031, P.R. China
  • Pages: 417-422
    |
    Published online on: November 29, 2016
       https://doi.org/10.3892/ol.2016.5442
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Abstract

Neuroblastoma is a complex form of cancer with highly heterogeneous clinical behavior that arises during childhood from precursor cells of the sympathetic nervous system. In patients with neuroblastoma, mortality often occurs as a result of metastasis. The disease predominantly spreads to bone marrow, with a survival rate of ~40%. The current study demonstrates that microRNA (miR)‑506 directly targets and downregulates Rho‑associated, coiled‑coil containing protein kinase 1 (ROCK1) in transforming growth factor (TGF)-β non-canonical pathways. It may be concluded that ROCK1 contributes to the invasion and migration of neuroblastoma cells by directly downregulating miR-506; thus, leading to the upregulation of ROCK1, which promotes cell invasion and migration. The present results provide a novel understanding of how miR-506 directly regulates TGF-β non-canonical signaling.
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Copy and paste a formatted citation
Spandidos Publications style
Li D, Cao Y, Li J, Xu J, Liu Q and Sun X: miR-506 suppresses neuroblastoma metastasis by targeting ROCK1. Oncol Lett 13: 417-422, 2017.
APA
Li, D., Cao, Y., Li, J., Xu, J., Liu, Q., & Sun, X. (2017). miR-506 suppresses neuroblastoma metastasis by targeting ROCK1. Oncology Letters, 13, 417-422. https://doi.org/10.3892/ol.2016.5442
MLA
Li, D., Cao, Y., Li, J., Xu, J., Liu, Q., Sun, X."miR-506 suppresses neuroblastoma metastasis by targeting ROCK1". Oncology Letters 13.1 (2017): 417-422.
Chicago
Li, D., Cao, Y., Li, J., Xu, J., Liu, Q., Sun, X."miR-506 suppresses neuroblastoma metastasis by targeting ROCK1". Oncology Letters 13, no. 1 (2017): 417-422. https://doi.org/10.3892/ol.2016.5442
Copy and paste a formatted citation
x
Spandidos Publications style
Li D, Cao Y, Li J, Xu J, Liu Q and Sun X: miR-506 suppresses neuroblastoma metastasis by targeting ROCK1. Oncol Lett 13: 417-422, 2017.
APA
Li, D., Cao, Y., Li, J., Xu, J., Liu, Q., & Sun, X. (2017). miR-506 suppresses neuroblastoma metastasis by targeting ROCK1. Oncology Letters, 13, 417-422. https://doi.org/10.3892/ol.2016.5442
MLA
Li, D., Cao, Y., Li, J., Xu, J., Liu, Q., Sun, X."miR-506 suppresses neuroblastoma metastasis by targeting ROCK1". Oncology Letters 13.1 (2017): 417-422.
Chicago
Li, D., Cao, Y., Li, J., Xu, J., Liu, Q., Sun, X."miR-506 suppresses neuroblastoma metastasis by targeting ROCK1". Oncology Letters 13, no. 1 (2017): 417-422. https://doi.org/10.3892/ol.2016.5442
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