The diagnostic utility of PAX8 immunostaining of malignant peritoneal mesothelioma presenting as serous ovarian carcinoma: A single‑center report of two cases

Nakamura,Kohei; Nakayama,Kentaro; Nagaoka,Risa; Nishisako,Kiyoka; Ishikawa,Masako; Katagiri,Hiroshi; Ishibashi,Tomoka; Sato,Emi; Amano,Chika; Kyo,Satoru

doi:10.3892/ol.2016.5444

January-2017 Volume 13 Issue 1

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January-2017 Volume 13 Issue 1

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Article Open Access

The diagnostic utility of PAX8 immunostaining of malignant peritoneal mesothelioma presenting as serous ovarian carcinoma: A single‑center report of two cases

Authors:
- Kohei Nakamura
- Kentaro Nakayama
- Risa Nagaoka
- Kiyoka Nishisako
- Masako Ishikawa
- Hiroshi Katagiri
- Tomoka Ishibashi
- Emi Sato
- Chika Amano
- Satoru Kyo
View Affiliations / Copyright

Affiliations: Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Shimane 6938501, Japan, Department of Organ Pathology, Shimane University School of Medicine, Izumo, Shimane 6938501, Japan

Copyright: © Nakamura et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 263-266
|
Published online on: November 30, 2016

https://doi.org/10.3892/ol.2016.5444
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Abstract

Malignant peritoneal mesotheliomas (MPMs) are rare and progressive tumors, which may present similarly to primary peritoneal carcinoma or ovarian carcinoma (OC). The current study reports two cases of MPM that initially presented with the features of OC, for which paired box 8 (PAX8) immunostaining was found to be useful for diagnosis. The two patients were women, aged 58 and 56 years, respectively. The primary presenting symptoms and clinical findings included prolonged abdominal pain, abdominal swelling and cough. The two cases were initially diagnosed as OC and were treated with primary debulking surgery. The patient in case 1 had no history of asbestos exposure, while the patient in case 2 did. Final diagnoses were determined based on histological and immunohistochemical results, which included negative PAX8 immunostaining, and which were consistent with MPM. The present cases demonstrated that PAX8 negativity may be a useful diagnostic biomarker for differentiating MPM from OC.

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