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Bioinformatics analysis of key genes and latent pathway interactions based on the anaplastic thyroid carcinoma gene expression profile

  • Authors:
    • Yun Huang
    • Yiming Tao
    • Xinying Li
    • Shi Chang
    • Bo Jiang
    • Feng Li
    • Zhi‑Ming Wang
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    Affiliations: Department of Hepatobiliary Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 167-176
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    Published online on: November 30, 2016
       https://doi.org/10.3892/ol.2016.5447
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Abstract

Anaplastic thyroid carcinoma (ATC) is an aggressive malignant disease in older adults with a high mortality rate. The present study aimed to examine several key genes and pathways, which are associated with ATC. The GSE33630 gene expression profile was downloaded from the Gene Expression Omnibus database, which included 11 ATC and 45 normal thyroid samples. The differentially expressed genes (DEGs) in ATC were identified using the Limma package in R. The Gene Ontology functions and Kyoto Encyclopedia of Genes and Genomes pathways of the selected DEGs were enriched using the Database for Annotation, Visualization and Integrated Discovery. A protein‑protein interaction (PPI) network of the DEGs was constructed to select significant modules. Furthermore, a latent pathway interactive network was constructed to select the significant pathways associated with ATC. A total of 665 DEGs in the ATC samples were screened, and four significant modules were selected from the PPI network. The DEGs in the four modules were enriched in several functions and pathways. In addition, 29 significant pathways associated with ATC were selected, and he Toll‑like receptor (TLR) signaling pathway, extracellular matrix (ECM)‑receptor interaction and cytokine‑cytokine interaction pathway were identified as important pathways. FBJ murine osteosarcoma viral oncogene homolog (FOS), chemokine C‑X‑C motif ligand 10 (CXCL10), collagen type V α1 (COL5A1) and chemokine (C‑C motif) ligand 28 (CCL28) were the key DEGs involved in these significant pathways. The data obtained in the present study revealed that the TLR signaling pathway, ECM‑receptor interaction and cytokine‑cytokine receptor interaction pathway, and the FOS, CXCL10, COL5A1, COL11A1 and CCL28 genes have different roles in the progression of ATC, and these may be used as therapeutic targets for ATC.
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View References

1 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2013. CA Cancer J Clin. 63:11–30. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Neff RL, Farrar WB, Kloos RT and Burman KD: Anaplastic thyroid cancer. Endocrinol Metab Clin North Am. 37:525–538. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Smallridge RC, Marlow LA and Copland JA: Anaplastic thyroid cancer: Molecular pathogenesis and emerging therapies. Endocr Relat Cancer. 16:17–44. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Are C and Shaha AR: Anaplastic thyroid carcinoma: Biology, pathogenesis, prognostic factors, and treatment approaches. Ann Surg Oncol. 13:453–464. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Passaro C, Abagnale A, Libertini S, Volpe M, Botta G, Cella L, Pacelli R, Halldèn G, Gillespie D and Portella G: Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells. Endocr Relat Cancer. 20:633–647. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Harach HR, Galíndez M, Campero M and Ceballos GA: Undifferentiated (anaplastic) thyroid carcinoma and iodine intake in Salta, Argentina. Endocr Pathol. 24:125–131. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Marlow LA, Von Roemeling CA, Cooper SJ, Zhang Y, Rohl SD, Arora S, Gonzales IM, Azorsa DO, Reddi HV, Tun HW, et al: Foxo3a drives proliferation in anaplastic thyroid carcinoma through transcriptional regulation of cyclin A1: A paradigm shift that impacts current therapeutic strategies. J Cell Sci. 125:4253–4263. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Kim SH, Kang JG, Kim CS, Ihm SH, Choi MG, Yoo HJ and Lee SJ: CCAAT/enhancer-binding protein-homologous protein sensitizes to SU5416 by modulating p21 and PI3K/Akt signal pathway in FRO anaplastic thyroid carcinoma cells. Horm Metab Res. 45:9–14. 2013.PubMed/NCBI

9 

Yu XM, Jaskula-Sztul R, Ahmed K, Harrison AD, Kunnimalaiyaan M and Chen H: Resveratrol induces differentiation markers expression in anaplastic thyroid carcinoma via activation of Notch1 signaling and suppresses cell growth. Mol Cancer Ther. 12:1276–1287. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Lim YC and Cha YY: Epigallocatechin-3-gallate induces growth inhibition and apoptosis of human anaplastic thyroid carcinoma cells through suppression of EGFR/ERK pathway and cyclin B1/CDK1 complex. J Surg Oncol. 104:776–780. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Becker N, Chernock RD, Nussenbaum B and Lewis JS Jr: Prognostic significance of β-human chorionic gonadotropin and PAX8 expression in anaplastic thyroid carcinoma. Thyroid. 24:319–326. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Kim KS, Min J-K, Liang ZL, Lee K, Lee JU, Bae KH, Lee MH, Lee SE, Ryu MJ, Kim SJ, et al: Aberrant l1 cell adhesion molecule affects tumor behavior and chemosensitivity in anaplastic thyroid carcinoma. Clin Cancer Res. 18:3071–3078. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Gauchotte G, Philippe C, Lacomme S, Léotard B, Wissler MP, Allou L, Toussaint B, Klein M, Vignaud JM and Bressenot A: BRAF, p53 and SOX2 in anaplastic thyroid carcinoma: Evidence for multistep carcinogenesis. Pathology. 43:447–452. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Hébrant A, Dom G, Dewaele M, Andry G, Trésallet C, Leteurtre E, Dumont JE and Maenhaut C: mRNA expression in papillary and anaplastic thyroid carcinoma: Molecular anatomy of a killing switch. PLoS One. 7:e378072012. View Article : Google Scholar : PubMed/NCBI

15 

He W, Qi B, Zhou Q, Lu C, Huang Q, Xian L and Chen M: Key genes and pathways in thyroid cancer based on gene set enrichment analysis. Oncol Rep. 30:1391–1397. 2013.PubMed/NCBI

16 

Xu Y, Deng Y, Ji Z, Liu H, Liu Y, Peng H, Wu J and Fan J: Identification of thyroid carcinoma related genes with mRMR and shortest path approaches. PLoS One. 9:e940222014. View Article : Google Scholar : PubMed/NCBI

17 

Gautier L, Cope L, Bolstad BM and Irizarry RA: affy-analysis of Affymetrix GeneChip data at the probe level. Bioinformatics. 20:307–315. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, et al: Bioconductor: Open software development for computational biology and bioinformatics. Genome Biol. 5:R802004. View Article : Google Scholar : PubMed/NCBI

19 

Smyth GK: Limma: Linear models for microarray dataBioinformatics and Computational Biology Solutions using R and Bioconductor. Gentleman R, Carey VJ, Huber W, Irizarry RA and Dudoit S: Springer; New Yotk, NY: pp. 397–420. 2005, View Article : Google Scholar

20 

Hulsegge I, Kommadath A and Smits MA: Globaltest and GOEAST: Two different approaches for gene ontology analysis. BMC Proc. 3:(Suppl 4). S102009. View Article : Google Scholar : PubMed/NCBI

21 

Kanehisa M and Goto S: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28:27–30. 2000. View Article : Google Scholar : PubMed/NCBI

22 

da W Huang, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2009.PubMed/NCBI

23 

Franceschini A, Szklarczyk D, Frankild S, Kuhn M, Simonovic M, Roth A, Lin J, Minguez P, Bork P, von Mering C and Jensen LJ: STRING v9. 1: Protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res. 41:(Database issue). D808–D815. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Kohl M, Wiese S and Warscheid B: Cytoscape: Software for visualization and analysis of biological networks. Methods Mol Biol. 696:291–303. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Niissalo A: Cytoscape and its Plugins. Department of Computer Science University of Helsinki Finland; 2007

26 

Pham L, Christadore L, Schaus S and Kolaczyk ED: Network-based prediction for sources of transcriptional dysregulation using latent pathway identification analysis. Proc Natl Acad Sci USA. 108:13347–13352. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Yu G, Wang LG, Han Y and He QY: clusterProfiler: An R package for comparing biological themes among gene clusters. OMICS. 16:284–287. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Jamali M and Ester M: TrustWalker: A random walk model for combining trust-based and item-based recommendation. Proceedings of the 15th ACM SIGKDD International Conference on Knowledge Discovery and Data Mining. ACM. New York, NY. pp. 397–406. 2009;

29 

Kim JH: Boostrap prediction intervals and bias-corrected forecasting. http://cran.rproject.org/web/packages/BootPR/index.html2009.

30 

Ruffilli I, Ferrari SM, Colaci M, Ferri C, Politti U, Antonelli A and Fallahi P: CXCR3 and CXCL10 in autoimmune thyroiditis. Clin Ter. 165:e237–e242. 2014.(In Italian). PubMed/NCBI

31 

Baloch ZW, Livolsi VA, Asa SL, Rosai J, Merino MJ, Randolph G, Vielh P, DeMay RM, Sidawy MK and Frable WJ: Diagnostic terminology and morphologic criteria for cytologic diagnosis of thyroid lesions: A synopsis of the national cancer institute thyroid fine-needle aspiration state of the science conference. Diagn Cytopathol. 36:425–437. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Fallahi P, Ferrari SM, Corrado A, Giuggioli D, Ferri C and Antonelli A: Targeting chemochine (C-X-C motif) receptor 3 in thyroid autoimmunity. Recent Pat Endocr Metab Immune Drug Discov. 8:95–101. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Antonelli A, Ferrari SM, Fallahi P, Piaggi S, Di Domenicantonio A, Galleri D, Santarpia L, Basolo F, Ferrannini E and Miccoli P: Variable modulation by cytokines and thiazolidinediones of the prototype Th1 chemokine CXCL10 in anaplastic thyroid cancer. Cytokine. 59:218–222. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Lin Q, Li M, Fang D, Fang J and Su SB: The essential roles of Toll-like receptor signaling pathways in sterile inflammatory diseases. Int Immunopharmacol. 11:1422–1432. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Mardente S, Mari E, Consorti F, Di Gioia C, Negri R, Etna M, Zicari A and Antonaci A: HMGB1 induces the overexpression of miR-222 and miR-221 and increases growth and motility in papillary thyroid cancer cells. Oncol Rep. 28:2285–2289. 2012.PubMed/NCBI

36 

Romagnani P, Rotondi M, Lazzeri E, Lasagni L, Francalanci M, Buonamano A, Milani S, Vitti P, Chiovato L, Tonacchera M, et al: Expression of IP-10/CXCL10 and MIG/CXCL9 in the thyroid and increased levels of IP-10/CXCL10 in the serum of patients with recent-onset Graves' disease. Am J Pathol. 161:195–206. 2002. View Article : Google Scholar : PubMed/NCBI

37 

Yousefi S, Hemmann S, Weber M, Hölzer C, Hartung K, Blaser K and Simon HU: IL-8 is expressed by human peripheral blood eosinophils. Evidence for increased secretion in asthma. J Immunol. 154:5481–5490. 1995.PubMed/NCBI

38 

Tanaka K, Towata S, Nakao K, Mizuguchi H, Hayakawa T, Niwa M, Ishii N and Nagayama Y: Thyroid cancer immuno-therapy with retroviral and adenoviral vectors expressing granulocyte macrophage colony stimulating factor and interleukin-12 in a rat model. Clin Endocrinol. 59:734–742. 2003. View Article : Google Scholar

39 

Kobawala TP, Patel GH, Gajjar DR, Patel KN, Thakor PB, Parekh UB, Patel KM, Shukla SN and Shah PM: Clinical utility of serum interleukin-8 and interferon-alpha in thyroid diseases. J Thyroid Res. 2011:2701492011. View Article : Google Scholar : PubMed/NCBI

40 

Bazhenova Elu, Kulikov AV, Tikhonova MA, Tsybko AS and Popova NK: Effects of stress on corticosterone level, expression of c-Fos gene and serotonin turnover in brain in mice with genetic predisposition to catalepsy. Ross Fiziol Zh Im I M Sechenova. 98:1070–1078. 2012.(In Russian). PubMed/NCBI

41 

Zhang X, Zhang L, Yang H, Huang X, Otu H, Libermann TA, DeWolf WC, Khosravi-Far R and Olumi AF: c-Fos as a proapoptotic agent in TRAIL-induced apoptosis in prostate cancer cells. Cancer Res. 67:9425–9434. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Watanabe T, Hiasa Y, Tokumoto Y, Hirooka M, Abe M, Ikeda Y, Matsuura B, Chung RT and Onji M: Protein kinase R modulates c-Fos and c-Jun signaling to promote proliferation of hepatocellular carcinoma with hepatitis C virus infection. PLoS One. 8:e677502013. View Article : Google Scholar : PubMed/NCBI

43 

Salvatore G, Nappi TC, Salerno P, Jiang Y, Garbi C, Ugolini C, Miccoli P, Basolo F, Castellone MD, Cirafici AM, et al: A cell proliferation and chromosomal instability signature in anaplastic thyroid carcinoma. Cancer Res. 67:10148–10158. 2007. View Article : Google Scholar : PubMed/NCBI

44 

Ingeson-Carlsson C and Nilsson M: Dual contribution of MAPK and PI3K in epidermal growth factor-induced destabilization of thyroid follicular integrity and invasion of cells into extracellular matrix. Exp Cell Res. 326:210–218. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Brown JC, Miller CJ, Posthumus M, Schwellnus MP and Collins M: The COL5A1 gene, ultra-marathon running performance, and range of motion. Int J Sports Physiol Perform. 6:485–496. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Kusunoki T, Nishida S, Kimoto-Kinoshita S, Murata K, Satou T and Tomura T: Type IV collagenase and immunostaining of type IV collagen in human thyroid tumors. Auris Nasus Larynx. 27:161–165. 2000. View Article : Google Scholar : PubMed/NCBI

47 

Kusunoki T, Nishida S, Kimoto-Kinoshita S, Murata K, Satou T and Tomura T: Type IV collagen, type IV collagenase activity and ability of cell proliferation in human thyroid tumours. Asian J Surg. 25:304–308. 2002. View Article : Google Scholar : PubMed/NCBI

48 

Kliese N, Gobrecht P, Pachow D, Andrae N, Wilisch-Neumann A, Kirches E, Riek-Burchardt M, Angenstein F, Reifenberger G, Riemenschneider MJ, et al: miRNA-145 is downregulated in atypical and anaplastic meningiomas and negatively regulates motility and proliferation of meningioma cells. Oncogene. 32:4712–4720. 2013. View Article : Google Scholar : PubMed/NCBI

49 

Christner PJ and Ayitey S: Extracellular matrix containing mutated fibrillin-1 (Fbn1) down regulates Col1a1, Col1a2, Col3a1, Col5a1, and Col5a2 mRNA levels in Tsk/+ and Tsk/Tsk embryonic fibroblasts. Amino Acids. 30:445–451. 2006. View Article : Google Scholar : PubMed/NCBI

50 

Cheon DJ, Tong Y, Sim MS, Dering J, Berel D, Cui X, Lester J, Beach JA, Tighiouart M, Walts AE, et al: A collagen-remodeling gene signature regulated by TGF-β signaling is associated with metastasis and poor survival in serous ovarian cancer. Clin Cancer Res. 20:711–723. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Huang Y, Tao Y, Li X, Chang S, Jiang B, Li F and Wang ZM: Bioinformatics analysis of key genes and latent pathway interactions based on the anaplastic thyroid carcinoma gene expression profile. Oncol Lett 13: 167-176, 2017.
APA
Huang, Y., Tao, Y., Li, X., Chang, S., Jiang, B., Li, F., & Wang, Z. (2017). Bioinformatics analysis of key genes and latent pathway interactions based on the anaplastic thyroid carcinoma gene expression profile. Oncology Letters, 13, 167-176. https://doi.org/10.3892/ol.2016.5447
MLA
Huang, Y., Tao, Y., Li, X., Chang, S., Jiang, B., Li, F., Wang, Z."Bioinformatics analysis of key genes and latent pathway interactions based on the anaplastic thyroid carcinoma gene expression profile". Oncology Letters 13.1 (2017): 167-176.
Chicago
Huang, Y., Tao, Y., Li, X., Chang, S., Jiang, B., Li, F., Wang, Z."Bioinformatics analysis of key genes and latent pathway interactions based on the anaplastic thyroid carcinoma gene expression profile". Oncology Letters 13, no. 1 (2017): 167-176. https://doi.org/10.3892/ol.2016.5447
Copy and paste a formatted citation
x
Spandidos Publications style
Huang Y, Tao Y, Li X, Chang S, Jiang B, Li F and Wang ZM: Bioinformatics analysis of key genes and latent pathway interactions based on the anaplastic thyroid carcinoma gene expression profile. Oncol Lett 13: 167-176, 2017.
APA
Huang, Y., Tao, Y., Li, X., Chang, S., Jiang, B., Li, F., & Wang, Z. (2017). Bioinformatics analysis of key genes and latent pathway interactions based on the anaplastic thyroid carcinoma gene expression profile. Oncology Letters, 13, 167-176. https://doi.org/10.3892/ol.2016.5447
MLA
Huang, Y., Tao, Y., Li, X., Chang, S., Jiang, B., Li, F., Wang, Z."Bioinformatics analysis of key genes and latent pathway interactions based on the anaplastic thyroid carcinoma gene expression profile". Oncology Letters 13.1 (2017): 167-176.
Chicago
Huang, Y., Tao, Y., Li, X., Chang, S., Jiang, B., Li, F., Wang, Z."Bioinformatics analysis of key genes and latent pathway interactions based on the anaplastic thyroid carcinoma gene expression profile". Oncology Letters 13, no. 1 (2017): 167-176. https://doi.org/10.3892/ol.2016.5447
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