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Ginsenoside Rh2 enhances the antitumor immunological response of a melanoma mice model

  • Authors:
    • Meng Wang
    • Shi‑Ju Yan
    • Hong‑Tao Zhang
    • Nan Li
    • Tao Liu
    • Ying‑Long  Zhang
    • Xiao‑Xiang Li
    • Qiong Ma
    • Xiu‑Chun Qiu
    • Qing‑Yu Fan
    • Bao‑An Ma
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedic Surgery Center and Orthopedic Oncology Institute of People's Liberation Army, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710038, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 681-685
    |
    Published online on: December 12, 2016
       https://doi.org/10.3892/ol.2016.5490
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Abstract

The treatment of malignant tumors following surgery is important in preventing relapse. Among all the post‑surgery treatments, immunomodulators have demonstrated satisfactory effects on preventing recurrence according to recent studies. Ginsenoside is a compound isolated from panax ginseng, which is a famous traditional Chinese medicine. Ginsenoside aids in killing tumor cells through numerous processes, including the antitumor processes of ginsenoside Rh2 and Rg1, and also affects the inflammatory processes of the immune system. However, the role that ginsenoside serves in antitumor immunological activity remains to be elucidated. Therefore, the present study aimed to analyze the effect of ginsenoside Rh2 on the antitumor immunological response. With a melanoma mice model, ginsenoside Rh2 was demonstrated to inhibit tumor growth and improved the survival time of the mice. Ginsenoside Rh2 enhanced T‑lymphocyte infiltration in the tumor and triggered cytotoxicity in spleen lymphocytes. In addition, the immunological response triggered by ginsenoside Rh2 could be transferred to other mice. In conclusion, the present study provides evidence that ginsenoside Rh2 treatment enhanced the antitumor immunological response, which may be a potential therapy for melanoma.
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Copy and paste a formatted citation
Spandidos Publications style
Wang M, Yan SJ, Zhang HT, Li N, Liu T, Zhang YL, Li XX, Ma Q, Qiu XC, Fan QY, Fan QY, et al: Ginsenoside Rh2 enhances the antitumor immunological response of a melanoma mice model. Oncol Lett 13: 681-685, 2017.
APA
Wang, M., Yan, S., Zhang, H., Li, N., Liu, T., Zhang, Y. ... Ma, B. (2017). Ginsenoside Rh2 enhances the antitumor immunological response of a melanoma mice model. Oncology Letters, 13, 681-685. https://doi.org/10.3892/ol.2016.5490
MLA
Wang, M., Yan, S., Zhang, H., Li, N., Liu, T., Zhang, Y., Li, X., Ma, Q., Qiu, X., Fan, Q., Ma, B."Ginsenoside Rh2 enhances the antitumor immunological response of a melanoma mice model". Oncology Letters 13.2 (2017): 681-685.
Chicago
Wang, M., Yan, S., Zhang, H., Li, N., Liu, T., Zhang, Y., Li, X., Ma, Q., Qiu, X., Fan, Q., Ma, B."Ginsenoside Rh2 enhances the antitumor immunological response of a melanoma mice model". Oncology Letters 13, no. 2 (2017): 681-685. https://doi.org/10.3892/ol.2016.5490
Copy and paste a formatted citation
x
Spandidos Publications style
Wang M, Yan SJ, Zhang HT, Li N, Liu T, Zhang YL, Li XX, Ma Q, Qiu XC, Fan QY, Fan QY, et al: Ginsenoside Rh2 enhances the antitumor immunological response of a melanoma mice model. Oncol Lett 13: 681-685, 2017.
APA
Wang, M., Yan, S., Zhang, H., Li, N., Liu, T., Zhang, Y. ... Ma, B. (2017). Ginsenoside Rh2 enhances the antitumor immunological response of a melanoma mice model. Oncology Letters, 13, 681-685. https://doi.org/10.3892/ol.2016.5490
MLA
Wang, M., Yan, S., Zhang, H., Li, N., Liu, T., Zhang, Y., Li, X., Ma, Q., Qiu, X., Fan, Q., Ma, B."Ginsenoside Rh2 enhances the antitumor immunological response of a melanoma mice model". Oncology Letters 13.2 (2017): 681-685.
Chicago
Wang, M., Yan, S., Zhang, H., Li, N., Liu, T., Zhang, Y., Li, X., Ma, Q., Qiu, X., Fan, Q., Ma, B."Ginsenoside Rh2 enhances the antitumor immunological response of a melanoma mice model". Oncology Letters 13, no. 2 (2017): 681-685. https://doi.org/10.3892/ol.2016.5490
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