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Review

A novel hysteroscopic approach for ovarian cancer screening/early diagnosis (Review)

  • Authors:
    • Salvatore Gizzo
    • Marco Noventa
    • Michela Quaranta
    • Amerigo Vitagliano
    • Carlo Saccardi
    • Pietro Litta
    • Donato Antona
  • View Affiliations / Copyright

    Affiliations: Department of Woman and Child Health, University of Padua, I-35128 Padua, Italy, Department of Obstetrics and Gynecology, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK
  • Pages: 549-553
    |
    Published online on: December 14, 2016
       https://doi.org/10.3892/ol.2016.5493
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Abstract

The lethality of epithelial ovarian cancer (EOC) may be due to common misconceptions regarding etiology and the absence of effective screening and early diagnostic tools. Reviews of histopathological surveys performed on the resected fallopian tubes of breast cancer (BRCA) mutation carriers, who underwent risk‑reducing salpingo‑oophorectomy, unexpectedly revealed the presence of occult carcinomas of the fallopian tubes. This finding prompted studies that demonstrated the most accredited theory of type II EOC development, which suggests that a large proportion of these tumors are derived from the fallopian tube. At present, no diagnostic tools or screening programs have been demonstrated to be effective or cost‑effective in improving the outcome of EOC; it is therefore imperative that the scientific community unite its efforts in the identification of a valid screening and/or early diagnostic method for the treatment of this lethal gynecological malignancy. To this end, the present paper proposes a novel tool for the screening/early diagnosis of EOC: The ‘Tuba‑check’. This novel approach is based on the possibility of acquiring specimens for tubal lumen cytology via hysteroscopy in a minimally‑invasive outpatient setting. The present study protocol aimed to validate the technical feasibility and oncological accuracy of the proposed approach, commencing with a cohort of patients with an expected increased oncological risk, including BRCA mutation carriers or those with a gene expression profile of ‘BRCA‑ness’. If the data collected by the present study protocol validates this approach, the ‘Tuba‑check’ may, in the near future, be extended for the treatment of all women, therefore reducing the number of victims of epithelial ovarian carcinoma.
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1 

Coleman MP, Forman D, Bryant H, Butler J, Rachet B, Maringe C, Nur U, Tracey E, Coory M, Hatcher J, et al: ICBP Module 1 Working Group: Cancer survival in Australia, Canada, Denmark, Norway, Sweden, and the UK, 1995–2007 (the International Cancer Benchmarking Partnership): An analysis of population-based cancer registry data. Lancet. 377:127–138. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2013. CA Cancer J Clin. 63:11–30. 2013. View Article : Google Scholar : PubMed/NCBI

3 

George SH and Shaw P: BRCA and early events in the development of serous ovarian cancer. Front Oncol. 4:52014. View Article : Google Scholar : PubMed/NCBI

4 

Kuhn E, Kurman RJ, Vang R, Sehdev AS, Han G, Soslow R, Wang TL and Shih IeM: TP53 mutations in serous tubal intraepithelial carcinoma and concurrent pelvic high-grade serous carcinoma - evidence supporting the clonal relationship of the two lesions. J Pathol. 226:421–426. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Cancer Genome Atlas Research Network, . Integrated genomic analyses of ovarian carcinoma. Nature. 474:609–615. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Gizzo S, Noventa M and Nardelli GB: Gardasil administration to hr-HPV-positive women and their partners. Trends Pharmacol Sci. 34:479–480. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Saccardi C, Gizzo S, Noventa M, Anis O, Di Gangi S, Patrelli TS, D'Antona D and Nardelli GB: High risk human papillomavirus DNA test: Could it be useful in low-grade cervical lesion triage? Five-year follow-up. Reprod Sci. 21:198–203. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Kurman RJ: Origin and molecular pathogenesis of ovarian high-grade serous carcinoma. Ann Oncol. 24:(Suppl 10). x16–x21. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Erickson BK, Conner MG and Landen CN Jr: The role of the fallopian tube in the origin of ovarian cancer. Am J Obstet Gynecol. 209:409–414. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Koshiyama M, Matsumura N and Konishi I: Recent concepts of ovarian carcinogenesis: Type I and type II. Biomed Res Int. 2014:9342612014. View Article : Google Scholar : PubMed/NCBI

11 

Li J, Abushahin N, Pang S, Xiang L, Chambers SK, Fadare O, Kong B and Zheng W: Tubal origin of ‘ovarian’ low-grade serous carcinoma. Mod Pathol. 24:1488–1499. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Schildkraut JM, Schwingl PJ, Bastos E, Evanoff A and Hughes C: Epithelial ovarian cancer risk among women with polycystic ovary syndrome. Obstet Gynecol. 88:554–559. 1996. View Article : Google Scholar : PubMed/NCBI

13 

Shih IeM and Kurman RJ: Ovarian tumorigenesis: A proposed model based on morphological and molecular genetic analysis. Am J Pathol. 164:1511–1518. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Kurman RJ and Shih IeM: Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer - shifting the paradigm. Hum Pathol. 42:918–931. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Gizzo S, Berretta R, Di Gangi S, Guido M, Zanni GC, Franceschetti I, Quaranta M, Plebani M, Nardelli GB and Patrelli TS: Borderline ovarian tumors and diagnostic dilemma of intraoperative diagnosis: Could preoperative He4 assay and ROMA score assessment increase the frozen section accuracy? A multicenter case-control study. Biomed Res Int. 2014:8035982014. View Article : Google Scholar : PubMed/NCBI

16 

Lawrenson K, MhawechFauceglia P, Worthington J, Spindler TJ, O'Brien D, Lee JM, Spain G, Sharifian M, Wang G, Darcy KM, et al: Identification of novel candidate biomarkers of epithelial ovarian cancer by profiling the secretomes of three-dimensional genetic models of ovarian carcinogenesis. Int J Cancer. 137:1806–1817. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Testa A, Kaijser J, Wynants L, Fischerova D, Van Holsbeke C, Franchi D, Savelli L, Epstein E, Czekierdowski A, Guerriero S, et al: Strategies to diagnose ovarian cancer: New evidence from phase 3 of the multicentre international IOTA study. Br J Cancer. 111:680–688. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Amal H, Shi DY, Ionescu R, Zhang W, Hua QL, Pan YY, Tao L, Liu H and Haick H: Assessment of ovarian cancer conditions from exhaled breath. Int J Cancer. 136:E614–E622. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Lum D, Guido R, Rodriguez E, Lee T, Mansuria S, D'Ambrosio L and Austin RM: Brush cytology of the fallopian tube and implications in ovarian cancer screening. J Minim Invasive Gynecol. 21:851–856. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Gizzo S, Noventa M, Saccardi C, Litta P, D'Antona D and Nardelli GB: Proposal on Raloxifene use after prophylactic salpingo-oophorectomy in BRCA1-2: Hypothesis and rationale. Eur J Cancer Prev. 23:514–515. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Gizzo S, Ancona E, Saccardi C, Patrelli TS, Berretta R, Anis O, Noventa M, Bertocco A, Fagherazzi S, Longone M, et al: Radical trachelectomy: The first step of fertility preservation in young women with cervical cancer (Review). Oncol Rep. 30:2545–2554. 2013.PubMed/NCBI

22 

Berretta R, Gizzo S, Dall'Asta A, Mazzone E, Monica M, Franchi L, Peri F, Patrelli TS and Modena A Bacchi: Risk of preterm delivery associated with prior treatment of cervical precancerous lesion according to the depth of the cone. Dis Markers. 35:721–726. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Kaijser J, Sayasneh A, Van Hoorde K, Ghaem-Maghami S, Bourne T, Timmerman D and Van Calster B: Presurgical diagnosis of adnexal tumours using mathematical models and scoring systems: A systematic review and meta-analysis. Hum Reprod Update. 20:449–462. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Gizzo S, Bertocco A, Saccardi C, Di Gangi S, Litta PS, D'antona D and Nardelli GB: Female sterilization: Update on clinical efficacy, side effects and contraindications. Minim Invasive Ther Allied Technol. 23:261–270. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Gizzo S, Noventa M, Quaranta M, Vitagliano A, Saccardi C, Litta P and Antona D: A novel hysteroscopic approach for ovarian cancer screening/early diagnosis (Review). Oncol Lett 13: 549-553, 2017.
APA
Gizzo, S., Noventa, M., Quaranta, M., Vitagliano, A., Saccardi, C., Litta, P., & Antona, D. (2017). A novel hysteroscopic approach for ovarian cancer screening/early diagnosis (Review). Oncology Letters, 13, 549-553. https://doi.org/10.3892/ol.2016.5493
MLA
Gizzo, S., Noventa, M., Quaranta, M., Vitagliano, A., Saccardi, C., Litta, P., Antona, D."A novel hysteroscopic approach for ovarian cancer screening/early diagnosis (Review)". Oncology Letters 13.2 (2017): 549-553.
Chicago
Gizzo, S., Noventa, M., Quaranta, M., Vitagliano, A., Saccardi, C., Litta, P., Antona, D."A novel hysteroscopic approach for ovarian cancer screening/early diagnosis (Review)". Oncology Letters 13, no. 2 (2017): 549-553. https://doi.org/10.3892/ol.2016.5493
Copy and paste a formatted citation
x
Spandidos Publications style
Gizzo S, Noventa M, Quaranta M, Vitagliano A, Saccardi C, Litta P and Antona D: A novel hysteroscopic approach for ovarian cancer screening/early diagnosis (Review). Oncol Lett 13: 549-553, 2017.
APA
Gizzo, S., Noventa, M., Quaranta, M., Vitagliano, A., Saccardi, C., Litta, P., & Antona, D. (2017). A novel hysteroscopic approach for ovarian cancer screening/early diagnosis (Review). Oncology Letters, 13, 549-553. https://doi.org/10.3892/ol.2016.5493
MLA
Gizzo, S., Noventa, M., Quaranta, M., Vitagliano, A., Saccardi, C., Litta, P., Antona, D."A novel hysteroscopic approach for ovarian cancer screening/early diagnosis (Review)". Oncology Letters 13.2 (2017): 549-553.
Chicago
Gizzo, S., Noventa, M., Quaranta, M., Vitagliano, A., Saccardi, C., Litta, P., Antona, D."A novel hysteroscopic approach for ovarian cancer screening/early diagnosis (Review)". Oncology Letters 13, no. 2 (2017): 549-553. https://doi.org/10.3892/ol.2016.5493
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