Open Access

Chromosome t(7;11)(p15;p15) translocation in acute myeloid leukemia coexisting with multilineage dyspoiesis and mutations in NRAS and WT1: A case report and literature review

  • Authors:
    • Jingke Yang
    • Xiaodong Lyu
    • Xinghu Zhu
    • Xiangguang Meng
    • Wenli Zuo
    • Hao Ai
    • Mei Deng
  • View Affiliations

  • Published online on: March 7, 2017     https://doi.org/10.3892/ol.2017.5823
  • Pages: 3066-3070
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The chromosomal translocation t(7;11)(p15;p15) and the resulting nucleoporin 98-homeobox A9 (NUP98-HOXA9) gene fusion is rare but recurrent genetic abnormity in acute myeloid leukemia (AML). The present study describes a case of AML plus maturation (‑M2) with multilineage dyspoiesis in a 30‑year‑old male in whom a 46,XY,t(7;11)(p15;p15) karyotype was detected through chromosome analysis. Subsequent molecular and sequencing analysis demonstrated a NUP98‑HOXA9 fusion gene with a type I fusion between NUP98 exon 12 and HOXA9 exon 1b, and mutations in neuroblastoma V‑Ras oncogene homolog and Wilms tumor 1. The patient achieved hematological complete remission (CR) following two courses of induction chemotherapy. However, the NUP98‑HOXA9 fusion gene remained detectable during the hematological CR period and following intensive consolidation chemotherapy. The disease relapsed 11 months after diagnosis, and the patient became refractory, with complications from an infection causing eventual mortality. The present case and literature review suggest that patients with AML and t(7;11) may have unique biological and clinical characteristics, and a poor prognosis.
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May-2017
Volume 13 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Yang J, Lyu X, Zhu X, Meng X, Zuo W, Ai H and Deng M: Chromosome t(7;11)(p15;p15) translocation in acute myeloid leukemia coexisting with multilineage dyspoiesis and mutations in NRAS and WT1: A case report and literature review. Oncol Lett 13: 3066-3070, 2017
APA
Yang, J., Lyu, X., Zhu, X., Meng, X., Zuo, W., Ai, H., & Deng, M. (2017). Chromosome t(7;11)(p15;p15) translocation in acute myeloid leukemia coexisting with multilineage dyspoiesis and mutations in NRAS and WT1: A case report and literature review. Oncology Letters, 13, 3066-3070. https://doi.org/10.3892/ol.2017.5823
MLA
Yang, J., Lyu, X., Zhu, X., Meng, X., Zuo, W., Ai, H., Deng, M."Chromosome t(7;11)(p15;p15) translocation in acute myeloid leukemia coexisting with multilineage dyspoiesis and mutations in NRAS and WT1: A case report and literature review". Oncology Letters 13.5 (2017): 3066-3070.
Chicago
Yang, J., Lyu, X., Zhu, X., Meng, X., Zuo, W., Ai, H., Deng, M."Chromosome t(7;11)(p15;p15) translocation in acute myeloid leukemia coexisting with multilineage dyspoiesis and mutations in NRAS and WT1: A case report and literature review". Oncology Letters 13, no. 5 (2017): 3066-3070. https://doi.org/10.3892/ol.2017.5823