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Article

Synthesis, characterization and anticancer activities of transition metal complexes with a nicotinohydrazone ligand

  • Authors:
    • Shanshan Shen
    • Hong Chen
    • Taofeng Zhu
    • Xiuqin Ma
    • Jun Xu
    • Wenjiao Zhu
    • Ruhua Chen
    • Jing Xie
    • Tieliang Ma
    • Lei Jia
    • Yuan Wang
    • Chunyan Peng
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing University, Nanjing, Jiangsu 210008, P.R. China, The Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu 214200, P.R. China, Department of Physics and Chemistry, Henan Polytechnic University, Jiaozuo, Henan 454000, P.R. China
  • Pages: 3169-3176
    |
    Published online on: March 14, 2017
       https://doi.org/10.3892/ol.2017.5857
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Abstract

The reaction of divalent transition metal salts and (E)-N'-(1-(pyridin-2-yl)ethylidene)nicotinohydrazide (penh) led to the formation of [Mn(penh)2] (complex 1), [Co(penh)2] (complex 2), [Cu(penh)2] (complex 3) and [Cd (penh)2] (complex 4) complexes. The four complexes were characterized using elemental analyses, infrared spectra and single‑crystal X‑ray diffraction analyses. Subsequently, the complexes were used for in vitro cell level experiments to determine potential antitumor effects. The results demonstrated that the complexes exhibited a similar structure; however, they were crystallized with distinct space groups. In comparison with the uncomplexed penh ligand, all four complexes were able to markedly decrease the proliferation rate of various types of tumor cell, including the human lung cancer cell line A549, human gastric cancer cell line BGC823 and human esophageal cancer cell line Eca109, in a concentration‑dependent manner. Furthermore, the complexes promoted tumor cell apoptosis, as demonstrated in the apoptosis assay, and this was confirmed using electrophoresis.
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Copy and paste a formatted citation
Spandidos Publications style
Shen S, Chen H, Zhu T, Ma X, Xu J, Zhu W, Chen R, Xie J, Ma T, Jia L, Jia L, et al: Synthesis, characterization and anticancer activities of transition metal complexes with a nicotinohydrazone ligand. Oncol Lett 13: 3169-3176, 2017.
APA
Shen, S., Chen, H., Zhu, T., Ma, X., Xu, J., Zhu, W. ... Peng, C. (2017). Synthesis, characterization and anticancer activities of transition metal complexes with a nicotinohydrazone ligand. Oncology Letters, 13, 3169-3176. https://doi.org/10.3892/ol.2017.5857
MLA
Shen, S., Chen, H., Zhu, T., Ma, X., Xu, J., Zhu, W., Chen, R., Xie, J., Ma, T., Jia, L., Wang, Y., Peng, C."Synthesis, characterization and anticancer activities of transition metal complexes with a nicotinohydrazone ligand". Oncology Letters 13.5 (2017): 3169-3176.
Chicago
Shen, S., Chen, H., Zhu, T., Ma, X., Xu, J., Zhu, W., Chen, R., Xie, J., Ma, T., Jia, L., Wang, Y., Peng, C."Synthesis, characterization and anticancer activities of transition metal complexes with a nicotinohydrazone ligand". Oncology Letters 13, no. 5 (2017): 3169-3176. https://doi.org/10.3892/ol.2017.5857
Copy and paste a formatted citation
x
Spandidos Publications style
Shen S, Chen H, Zhu T, Ma X, Xu J, Zhu W, Chen R, Xie J, Ma T, Jia L, Jia L, et al: Synthesis, characterization and anticancer activities of transition metal complexes with a nicotinohydrazone ligand. Oncol Lett 13: 3169-3176, 2017.
APA
Shen, S., Chen, H., Zhu, T., Ma, X., Xu, J., Zhu, W. ... Peng, C. (2017). Synthesis, characterization and anticancer activities of transition metal complexes with a nicotinohydrazone ligand. Oncology Letters, 13, 3169-3176. https://doi.org/10.3892/ol.2017.5857
MLA
Shen, S., Chen, H., Zhu, T., Ma, X., Xu, J., Zhu, W., Chen, R., Xie, J., Ma, T., Jia, L., Wang, Y., Peng, C."Synthesis, characterization and anticancer activities of transition metal complexes with a nicotinohydrazone ligand". Oncology Letters 13.5 (2017): 3169-3176.
Chicago
Shen, S., Chen, H., Zhu, T., Ma, X., Xu, J., Zhu, W., Chen, R., Xie, J., Ma, T., Jia, L., Wang, Y., Peng, C."Synthesis, characterization and anticancer activities of transition metal complexes with a nicotinohydrazone ligand". Oncology Letters 13, no. 5 (2017): 3169-3176. https://doi.org/10.3892/ol.2017.5857
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