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Article Open Access

MicroRNA gene polymorphisms and the risk of colorectal cancer

  • Authors:
    • Guo-Qiang Rong
    • Xin-Mei Zhang
    • Bo Chen
    • Xiao-Dong Yang
    • Hao-Rong Wu
    • Wei Gong
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, P.R. China, Department of Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Department of Surgery, The Fifth People's Hospital of Changshu, Changshu, Jiangsu 215500, P.R. China
    Copyright: © Rong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3617-3623
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    Published online on: March 21, 2017
       https://doi.org/10.3892/ol.2017.5885
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Abstract

The present study was carried out to demonstrate the epidemiological value of microRNA (miRNA) in colorectal cancer (CRC) by investigating the association between miRNA gene polymorphisms and the susceptibility to CRC. Multiple meta-analyses of reported data were conducted, and odds ratio values and 95% confidence intervals were used to assess these associations. Stata 11.0 software was used to analyze the data and the modified Jadad quality score was employed to evaluate the quality of the retrieved studies. We retrieved 38 studies on the association between miRNA polymorphisms and risk of CRC, however only 15 met the requirements of the inclusion criteria. In conclusion, we identified a variety of miRNAs (miRNA-let-7, miR-34b/c, miR-146a, miR-603 and miR-149) gene polymorphisms that are associated with susceptibility to CRC. However, some miRNAs (miR-192a, miR-608 and miR-27a) are associated with CRC, but not susceptibility to CRC. The results have limitations given the relatively low number of studies available. Therefore, it is necessary to collect data from large sample-size studies to further validate the results.
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Copy and paste a formatted citation
Spandidos Publications style
Rong G, Zhang X, Chen B, Yang X, Wu H and Gong W: MicroRNA gene polymorphisms and the risk of colorectal cancer. Oncol Lett 13: 3617-3623, 2017.
APA
Rong, G., Zhang, X., Chen, B., Yang, X., Wu, H., & Gong, W. (2017). MicroRNA gene polymorphisms and the risk of colorectal cancer. Oncology Letters, 13, 3617-3623. https://doi.org/10.3892/ol.2017.5885
MLA
Rong, G., Zhang, X., Chen, B., Yang, X., Wu, H., Gong, W."MicroRNA gene polymorphisms and the risk of colorectal cancer". Oncology Letters 13.5 (2017): 3617-3623.
Chicago
Rong, G., Zhang, X., Chen, B., Yang, X., Wu, H., Gong, W."MicroRNA gene polymorphisms and the risk of colorectal cancer". Oncology Letters 13, no. 5 (2017): 3617-3623. https://doi.org/10.3892/ol.2017.5885
Copy and paste a formatted citation
x
Spandidos Publications style
Rong G, Zhang X, Chen B, Yang X, Wu H and Gong W: MicroRNA gene polymorphisms and the risk of colorectal cancer. Oncol Lett 13: 3617-3623, 2017.
APA
Rong, G., Zhang, X., Chen, B., Yang, X., Wu, H., & Gong, W. (2017). MicroRNA gene polymorphisms and the risk of colorectal cancer. Oncology Letters, 13, 3617-3623. https://doi.org/10.3892/ol.2017.5885
MLA
Rong, G., Zhang, X., Chen, B., Yang, X., Wu, H., Gong, W."MicroRNA gene polymorphisms and the risk of colorectal cancer". Oncology Letters 13.5 (2017): 3617-3623.
Chicago
Rong, G., Zhang, X., Chen, B., Yang, X., Wu, H., Gong, W."MicroRNA gene polymorphisms and the risk of colorectal cancer". Oncology Letters 13, no. 5 (2017): 3617-3623. https://doi.org/10.3892/ol.2017.5885
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