Open Access

MicroRNA gene polymorphisms and the risk of colorectal cancer

  • Authors:
    • Guo-Qiang Rong
    • Xin-Mei Zhang
    • Bo Chen
    • Xiao-Dong Yang
    • Hao-Rong Wu
    • Wei Gong
  • View Affiliations

  • Published online on: March 21, 2017     https://doi.org/10.3892/ol.2017.5885
  • Pages: 3617-3623
  • Copyright: © Rong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study was carried out to demonstrate the epidemiological value of microRNA (miRNA) in colorectal cancer (CRC) by investigating the association between miRNA gene polymorphisms and the susceptibility to CRC. Multiple meta-analyses of reported data were conducted, and odds ratio values and 95% confidence intervals were used to assess these associations. Stata 11.0 software was used to analyze the data and the modified Jadad quality score was employed to evaluate the quality of the retrieved studies. We retrieved 38 studies on the association between miRNA polymorphisms and risk of CRC, however only 15 met the requirements of the inclusion criteria. In conclusion, we identified a variety of miRNAs (miRNA-let-7, miR-34b/c, miR-146a, miR-603 and miR-149) gene polymorphisms that are associated with susceptibility to CRC. However, some miRNAs (miR-192a, miR-608 and miR-27a) are associated with CRC, but not susceptibility to CRC. The results have limitations given the relatively low number of studies available. Therefore, it is necessary to collect data from large sample-size studies to further validate the results.
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May-2017
Volume 13 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Rong G, Zhang X, Chen B, Yang X, Wu H and Gong W: MicroRNA gene polymorphisms and the risk of colorectal cancer. Oncol Lett 13: 3617-3623, 2017
APA
Rong, G., Zhang, X., Chen, B., Yang, X., Wu, H., & Gong, W. (2017). MicroRNA gene polymorphisms and the risk of colorectal cancer. Oncology Letters, 13, 3617-3623. https://doi.org/10.3892/ol.2017.5885
MLA
Rong, G., Zhang, X., Chen, B., Yang, X., Wu, H., Gong, W."MicroRNA gene polymorphisms and the risk of colorectal cancer". Oncology Letters 13.5 (2017): 3617-3623.
Chicago
Rong, G., Zhang, X., Chen, B., Yang, X., Wu, H., Gong, W."MicroRNA gene polymorphisms and the risk of colorectal cancer". Oncology Letters 13, no. 5 (2017): 3617-3623. https://doi.org/10.3892/ol.2017.5885