Open Access

The association of p53 expression levels with clinicopathological features and prognosis of patients with colon cancer following surgery

  • Authors:
    • Da‑Zhong Cao
    • Xi‑Long Ou
    • Ting Yu
  • View Affiliations

  • Published online on: March 27, 2017     https://doi.org/10.3892/ol.2017.5929
  • Pages: 3538-3546
  • Copyright: © Cao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The present study aimed to examine the association of p53 expression levels with clinicopathological features and prognosis of patients with colon cancer following surgery. The present study included 484 patients with colon cancer that underwent colon resection between December 2003 and December 2011. All follow‑ups were censored in December 2013 with a median follow‑up time of 43 months. Kaplan‑Meier survival curves and Cox regression analysis were used to determine predictors for overall survival rate. p53 expression status (positive or negative) was significantly different between patient groups when categorized by age distribution, disease course, tumor location, maximum tumor diameter, depth of tumor invasion, Dukes' stage, distant metastasis and lymph node (LN) metastasis (P<0.05). Cox regression analysis revealed that age, surgery type, histological subtypes, tumor size, tumor location, LN metastasis, distant metastases, Dukes' stage and p53 expression status are independent factors influencing the survival rate of patients with colon cancer following surgery (P<0.05). Therefore, the present study revealed that the loss of p53 expression levels in tumors was associated with aggressive clinicopathological characteristics in patients with colon cancer.
View Figures
View References

Related Articles

Journal Cover

May-2017
Volume 13 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Cao DZ, Ou XL and Yu T: The association of p53 expression levels with clinicopathological features and prognosis of patients with colon cancer following surgery. Oncol Lett 13: 3538-3546, 2017
APA
Cao, D., Ou, X., & Yu, T. (2017). The association of p53 expression levels with clinicopathological features and prognosis of patients with colon cancer following surgery. Oncology Letters, 13, 3538-3546. https://doi.org/10.3892/ol.2017.5929
MLA
Cao, D., Ou, X., Yu, T."The association of p53 expression levels with clinicopathological features and prognosis of patients with colon cancer following surgery". Oncology Letters 13.5 (2017): 3538-3546.
Chicago
Cao, D., Ou, X., Yu, T."The association of p53 expression levels with clinicopathological features and prognosis of patients with colon cancer following surgery". Oncology Letters 13, no. 5 (2017): 3538-3546. https://doi.org/10.3892/ol.2017.5929