Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
May-2017 Volume 13 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2017 Volume 13 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

The association of p53 expression levels with clinicopathological features and prognosis of patients with colon cancer following surgery

  • Authors:
    • Da‑Zhong Cao
    • Xi‑Long Ou
    • Ting Yu
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, The Affiliated ZhongDa Hospital of Southeast University, Nanjing, Jiangsu 210009, P.R. China
    Copyright: © Cao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3538-3546
    |
    Published online on: March 27, 2017
       https://doi.org/10.3892/ol.2017.5929
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study aimed to examine the association of p53 expression levels with clinicopathological features and prognosis of patients with colon cancer following surgery. The present study included 484 patients with colon cancer that underwent colon resection between December 2003 and December 2011. All follow‑ups were censored in December 2013 with a median follow‑up time of 43 months. Kaplan‑Meier survival curves and Cox regression analysis were used to determine predictors for overall survival rate. p53 expression status (positive or negative) was significantly different between patient groups when categorized by age distribution, disease course, tumor location, maximum tumor diameter, depth of tumor invasion, Dukes' stage, distant metastasis and lymph node (LN) metastasis (P<0.05). Cox regression analysis revealed that age, surgery type, histological subtypes, tumor size, tumor location, LN metastasis, distant metastases, Dukes' stage and p53 expression status are independent factors influencing the survival rate of patients with colon cancer following surgery (P<0.05). Therefore, the present study revealed that the loss of p53 expression levels in tumors was associated with aggressive clinicopathological characteristics in patients with colon cancer.
View Figures

Figure 1

View References

1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Merika E, Saif MW, Katz A, Syrigos K and Morse M: Review. Colon cancer vaccines: An update. In vivo. 24:607–628. 2010.PubMed/NCBI

3 

Lee DH, Keum N and Giovannucci EL: Colorectal cancer epidemiology in the nurses' health study. Am J Public Health. 106:1599–1607. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Arnold M, Sierra MS, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global patterns and trends in colorectal cancer incidence and mortality. Gut pii: gutjnl-2015-310912. 2016.(Epub ahead of print).

5 

Stein A, Atanackovic D and Bokemeyer C: Current standards and new trends in the primary treatment of colorectal cancer. Eur J Cancer. 47:(Suppl 3). S312–S314. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Cunningham D, Atkin W, Lenz HJ, Lynch HT, Minsky B, Nordlinger B and Starling N: Colorectal cancer. Lancet. 375:1030–1047. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Desch CE, Benson AB III, Somerfield MR, Flynn PJ, Krause C, Loprinzi CL, Minsky BD, Pfister DG, Virgo KS and Petrelli NJ: American Society of Clinical Oncology: Colorectal cancer surveillance: 2005 update of an American society of clinical oncology practice guideline. J Clin Oncol. 23:8512–8519. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Engstrom PF, Arnoletti JP, Benson AB III, Chen YJ, Choti MA, Cooper HS, Covey A, Dilawari RA, Early DS, Enzinger PC, et al: NCCN clinical practice guidelines in oncology: Colon cancer. J Natl Compr Canc Netw. 7:778–831. 2009.PubMed/NCBI

9 

Jeffery M, Hickey BE and Hider PN: Follow-up strategies for patients treated for non-metastatic colorectal cancer. Cochrane Database Syst Rev. CD002200:2007. View Article : Google Scholar

10 

Tjandra JJ and Chan MK: Follow-up after curative resection of colorectal cancer: A meta-analysis. Dis Colon Rectum. 50:1783–1799. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Figueredo A, Rumble RB, Maroun J, Earle CC, Cummings B, McLeod R, Zuraw L and Zwaal C: Gastrointestinal Cancer Disease Site Group of Cancer Care Ontario's Program in Evidence-based Care: Follow-up of patients with curatively resected colorectal cancer: A practice guideline. BMC Cancer. 3:262003. View Article : Google Scholar : PubMed/NCBI

12 

Longo WE, Virgo KS, Johnson FE, Oprian CA, Vernava AM, Wade TP, Phelan MA, Henderson WG, Daley J and Khuri SF: Risk factors for morbidity and mortality after colectomy for colon cancer. Dis Colon Rectum. 43:83–91. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Debarros M and Steele SR: Perioperative protocols in colorectal surgery. Clinics Colon Rrectal Surg. 26:139–145. 2013. View Article : Google Scholar

14 

Siegel R, Desantis C and Jemal A: Colorectal cancer statistics, 2014. CA Cancer J Clin. 64:104–117. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Nasif WA, Lotfy M, El-Sayed IH, El-Kenawy Ael M, El-Shahat M and El-Hak NG: Implications of CEA and p53 overexpression in the poor prognosis of colorectal cancer. Med Oncol. 23:237–244. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Morner ME, Gunnarsson U, Jestin P and Svanfeldt M: The importance of blood loss during colon cancer surgery for long-term survival: An epidemiological study based on a population based register. Ann Surg. 255:1126–1128. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Chang GJ, Rodriguez-Bigas MA, Skibber JM and Moyer VA: Lymph node evaluation and survival after curative resection of colon cancer: Systematic review. J Natl Cancer Inst. 99:433–441. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Gunderson LL, Jessup JM, Sargent DJ, Greene FL and Stewart AK: Revised TN categorization for colon cancer based on national survival outcomes data. J Clin Oncol. 28:264–271. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Parnaby CN, Scott NW, Ramsay G, MacKay C, Samuel L, Murray GI and Loudon MA: Prognostic value of lymph node ratio and extramural vascular invasion on survival for patients undergoing curative colon cancer resection. Br J Cancer. 113:212–219. 2015. View Article : Google Scholar : PubMed/NCBI

20 

García-Solano J, Conesa-Zamora P, Trujillo-Santos J, Mäkinen MJ and Pérez-Guillermo M: Tumour budding and other prognostic pathological features at invasive margins in serrated colorectal adenocarcinoma: A comparative study with conventional carcinoma. Histopathology. 59:1046–1056. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Saha AK, Smith KJ, Sue-Ling H, Sagar PM, Burke D and Finan PJ: Prognostic factors for survival after curative resection of Dukes' B colonic cancer. Colorectal Dis. 13:1390–1394. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Bouzourene H, Gervaz P, Cerottini JP, Benhattar J, Chaubert P, Saraga E, Pampallona S, Bosman FT and Givel JC: p53 and Ki-ras as prognostic factors for Dukes' stage B colorectal cancer. Eur J Cancer. 36:1008–1015. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Allegra CJ, Paik S, Colangelo LH, Parr AL, Kirsch I, Kim G, Klein P, Johnston PG, Wolmark N and Wieand HS: Prognostic value of thymidylate synthase, Ki-67, and p53 in patients with Dukes' B and C colon cancer: A national cancer institute-national surgical adjuvant breast and bowel project collaborative study. J Clin Oncol. 21:241–250. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Lane DP: Cancer. p53, guardian of the genome. Nature. 358:15–16. 1992. View Article : Google Scholar : PubMed/NCBI

25 

Perrone G, Vincenzi B, Santini D, Verzì A, Tonini G, Vetrani A and Rabitti C: Correlation of p53 and bcl-2 expression with vascular endothelial growth factor (VEGF), microvessel density (MVD) and clinico-pathological features in colon cancer. Cancer Lett. 208:227–234. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Pu XX, Huang GL, Guo HQ, Guo CC, Li H, Ye S, Ling S, Jiang L, Tian Y and Lin TY: Circulating miR-221 directly amplified from plasma is a potential diagnostic and prognostic marker of colorectal cancer and is correlated with p53 expression. J Gastroenterol Hepatol. 25:1674–1680. 2010. View Article : Google Scholar : PubMed/NCBI

27 

El-Serafi MM, Bahnassy AA, Ali NM, Eid SM, Kamel MM, Abdel-Hamid NA and Zekri AR: The prognostic value of c-Kit, K-ras codon 12, and p53 codon 72 mutations in Egyptian patients with stage II colorectal cancer. Cancer. 116:4954–4964. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Liang JT, Huang KC, Jeng YM, Lee PH, Lai HS and Hsu HC: Microvessel density, cyclo-oxygenase 2 expression, K-ras mutation and p53 overexpression in colonic cancer. Br J Surg. 91:355–361. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Resnick MB, Routhier J, Konkin T, Sabo E and Pricolo VE: Epidermal growth factor receptor, c-MET, beta-catenin, and p53 expression as prognostic indicators in stage II colon cancer: A tissue microarray study. Clin Cancer Res. 10:3069–3075. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Nasif WA, El-Emshaty HM, Tabll A, Elmasry SA, Attallah AM and Elhak Gad NA: Immunoreactivity evaluation of mutant p53 gene product with DNA ploidy pattern in colorectal carcinoma. Hepatogastroenterology. 51:1001–1006. 2004.PubMed/NCBI

31 

Sarasqueta AF, Forte G, Corver WE, de Miranda NF, Ruano D, van Eijk R, Oosting J, Tollenaar RA, van Wezel T and Morreau H: Integral analysis of p53 and its value as prognostic factor in sporadic colon cancer. BMC Cancer. 13:2772013. View Article : Google Scholar : PubMed/NCBI

32 

Allegra CJ, Parr AL, Wold LE, Mahoney MR, Sargent DJ, Johnston P, Klein P, Behan K, O'Connell MJ, Levitt R, et al: Investigation of the prognostic and predictive value of thymidylate synthase, p53, and Ki-67 in patients with locally advanced colon cancer. J Clin Oncol. 20:1735–1743. 2002. View Article : Google Scholar : PubMed/NCBI

33 

Li M and Gu J: Changing patterns of colorectal cancer in China over a period of 20 years. World J Gastroenterol. 11:4685–4688. 2005. View Article : Google Scholar : PubMed/NCBI

34 

Dilmeç F, Özgönül A, Akkafa F, Uzunkoy A and Kuilenburg ABPV: Determination of ApaI and TaqI Polymorphisms of VDR gene in a group of Turkish patients with colorectal cancer. Hernia. 19:21258–21263. 2009.

35 

Watanabe T, Wu TT, Catalano PJ, Ueki T, Satriano R, Haller DG, Benson AB III and Hamilton SR: Molecular predictors of survival after adjuvant chemotherapy for colon cancer. N Engl J Med. 344:1196–1206. 2001. View Article : Google Scholar : PubMed/NCBI

36 

Paluszkiewicz P, Berbec H, Pawlowska-Wakowicz B, Cybulski M and Paszkowska A: p53 protein accumulation in colorectal cancer tissue has prognostic value only in left-sided colon tumours. Cancer Detect Prev. 28:252–259. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Zeng ZS, Sarkis AS, Zhang ZF, Klimstra DS, Charytonowicz E, Guillem JG, Cordon-Cardo C and Cohen AM: p53 nuclear overexpression: An independent predictor of survival in lymph node-positive colorectal cancer patients. J Clin Oncol. 12:2043–2050. 1994. View Article : Google Scholar : PubMed/NCBI

38 

Lan YT, Chang SC, Li AF, Lin TC, Chen WS, Jiang JK, Yang SH, Wang HS and Lin JK: p53 protein accumulation as a prognostic marker in sporadic colorectal cancer. Int J Colorectal Dis. 22:499–506. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Veruttipong D, Soliman AS, Gilbert SF, Blachley TS, Hablas A, Ramadan M, Rozek LS and Seifeldin IA: Age distribution, polyps and rectal cancer in the Egyptian population-based cancer registry. World J Gastroenterol. 18:3997–4003. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Fang YJ, Wu XJ, Zhao Q, Li LR, Lu ZH, Ding PR, Zhang RX, Kong LH, Wang FL, Lin JZ, et al: Hospital-based colorectal cancer survival trend of different tumor locations from 1960s to 2000s. PLoS One. 8:e735282013. View Article : Google Scholar : PubMed/NCBI

41 

Elferink MA, de Jong KP, Klaase JM, Siemerink EJ and de Wilt JH: Metachronous metastases from colorectal cancer: A population-based study in North-East Netherlands. Int J Colorectal Dis. 30:205–212. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Deliu IC, Georgescu EF and Bezna MC: Analysis of prognostic factors in colorectal carcinoma. Rev Med Chir Soc Med Nat Iasi. 118:808–816. 2014.PubMed/NCBI

43 

Okuno K: Surgical treatment for digestive cancer. Current issues- colon cancer. Dig Surg. 24:108–114. 2007. View Article : Google Scholar : PubMed/NCBI

44 

Inoue M, Ohta M, Iuchi K, Matsumura A, Ideguchi K, Yasumitsu T, Nakagawa K, Fukuhara K, Maeda H, Takeda S, et al: Benefits of surgery for patients with pulmonary metastases from colorectal carcinoma. Ann Thorac Surg. 78:238–244. 2004. View Article : Google Scholar : PubMed/NCBI

45 

Inoue M, Ohta M, Iuchi K, Matsumura A, Ideguchi K, Yasumitsu T, Nakagawa K, Fukuhara K, Maeda H, Takeda S, et al: Benefits of surgery for patients with pulmonary metastases from colorectal carcinoma. Ann Thorac Surg. 78:238–244. 2004. View Article : Google Scholar : PubMed/NCBI

46 

Kobayashi H, West NP, Takahashi K, Perrakis A, Weber K, Hohenberger W, Quirke P and Sugihara K: Quality of surgery for stage III colon cancer: Comparison between England, Germany, and Japan. Ann Surg Oncol. 21:(Suppl 3). S398–S404. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Ahmadi O, Stringer MD, Black MA and McCall JL: Influence of age and site of disease on lymph node yield in colorectal cancer. N Z Med J. 127:31–40. 2014.PubMed/NCBI

48 

Ueda Y, Yasuda K, Inomata M, Shiraishi N, Yokoyama S and Kitano S: Biological predictors of survival in stage II colorectal cancer. Mol Clin Oncol. 1:643–648. 2013.PubMed/NCBI

49 

Galizia G, Ferraraccio F, Lieto E, Orditura M, Castellano P, Imperatore V, Romano C, Vollaro M, Agostini B, Pignatelli C and De Vita F: Prognostic value of p27, p53, and vascular endothelial growth factor in Dukes A and B colon cancer patients undergoing potentially curative surgery. Dis Colon Rectum. 47:1904–1914. 2004. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Cao DZ, Ou XL and Yu T: The association of p53 expression levels with clinicopathological features and prognosis of patients with colon cancer following surgery. Oncol Lett 13: 3538-3546, 2017.
APA
Cao, D., Ou, X., & Yu, T. (2017). The association of p53 expression levels with clinicopathological features and prognosis of patients with colon cancer following surgery. Oncology Letters, 13, 3538-3546. https://doi.org/10.3892/ol.2017.5929
MLA
Cao, D., Ou, X., Yu, T."The association of p53 expression levels with clinicopathological features and prognosis of patients with colon cancer following surgery". Oncology Letters 13.5 (2017): 3538-3546.
Chicago
Cao, D., Ou, X., Yu, T."The association of p53 expression levels with clinicopathological features and prognosis of patients with colon cancer following surgery". Oncology Letters 13, no. 5 (2017): 3538-3546. https://doi.org/10.3892/ol.2017.5929
Copy and paste a formatted citation
x
Spandidos Publications style
Cao DZ, Ou XL and Yu T: The association of p53 expression levels with clinicopathological features and prognosis of patients with colon cancer following surgery. Oncol Lett 13: 3538-3546, 2017.
APA
Cao, D., Ou, X., & Yu, T. (2017). The association of p53 expression levels with clinicopathological features and prognosis of patients with colon cancer following surgery. Oncology Letters, 13, 3538-3546. https://doi.org/10.3892/ol.2017.5929
MLA
Cao, D., Ou, X., Yu, T."The association of p53 expression levels with clinicopathological features and prognosis of patients with colon cancer following surgery". Oncology Letters 13.5 (2017): 3538-3546.
Chicago
Cao, D., Ou, X., Yu, T."The association of p53 expression levels with clinicopathological features and prognosis of patients with colon cancer following surgery". Oncology Letters 13, no. 5 (2017): 3538-3546. https://doi.org/10.3892/ol.2017.5929
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team