Differentiation between gastrointestinal schwannomas and gastrointestinal stromal tumors by computed tomography

He,Ming‑Yan; Zhang,Rong; Peng,Zhenpeng; Li,Yin; Xu,Ling; Jiang,Mengjie; Li,Zi‑Ping; Feng,Shi‑Ting

doi:10.3892/ol.2017.5955

May-2017 Volume 13 Issue 5

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May-2017 Volume 13 Issue 5

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Article

Differentiation between gastrointestinal schwannomas and gastrointestinal stromal tumors by computed tomography

Authors:
- Ming‑Yan He
- Rong Zhang
- Zhenpeng Peng
- Yin Li
- Ling Xu
- Mengjie Jiang
- Zi‑Ping Li
- Shi‑Ting Feng
View Affiliations / Copyright

Affiliations: Department of Radiology, The First Affiliated Hospital, Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China, Department of Radiology, The Tumor Hospital, Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China, Department of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China, Faculty of Medicine and Dentistry, University of Western Australia, Perth, WA 6009, Australia
Pages: 3746-3752
|
Published online on: March 29, 2017

https://doi.org/10.3892/ol.2017.5955
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Abstract

The aim of the present study was to identify computed tomography (CT) features to assist in differentiating gastrointestinal schwannomas from gastrointestinal stromal tumors (GISTs). CT images of gastrointestinal schwannomas (n=15) and GISTs (n=50) were analyzed. The absolute CT values of tumor/aorta during plain scan/arterial phase/venous phase were recorded as tumor plain scan (Tp)/aorta plain scan (Ap), tumor arterial phase (Ta)/aorta arterial phase (Aa) and tumor venous phase (Tv)/aorta venous phase (Av), respectively, and normalized CT values of the three phases were calculated as Sp=Tp/Ap, Sa=Ta/Aa and Sv=Tv/Av, respectively. The difference in tumor CT value between arterial and venous phases was calculated and recorded as Tv‑a. CT data including tumor size, contour, margin, growth pattern, presence of calcification, cystic change, hemorrhage, ulceration, perilesional lymph nodes (PLNs), local invasion to surrounding structures, metastasis, ascites, vasculatures, enhancement pattern/degree, Tp/Ta/Tv and Sp/Sa/Sv were evaluated for each patient. Receiver operating characteristic (ROC) curve analysis was used to assess the ability of the CT data to differentiate gastrointestinal schwannomas from GISTs. Compared with GISTs, gastrointestinal schwannomas more frequently demonstrated round contouring, relatively smaller tumor size, a homogeneous enhancement pattern, with the presence of PLNs and a higher level of vasculature (P<0.05), whilst the presence of cystic changes were more common in GISTs compared with gastrointestinal schwannomas (P<0.05). The Sa, Ta and Tv‑a of gastrointestinal schwannomas were less compared with those of GISTs (P<0.05). The difference in margin, growth pattern, intra‑tumoral calcifications and hemorrhage were insignificant (P>0.05). ROC analysis indicated that tumor size, cystic change, the presence of PLNs, tumor enhancement pattern and Sa demonstrated improved diagnostic potential compared with others [area under the curve (AUC) >0.7], amongst which cystic change demonstrated the best diagnostic ability (AUC=0.82). Size exhibited the highest sensitivity, 90%, and cystic change, Sa exhibited the best specificity, 87%. Quantitative analysis indicated that certain features aided the differentiation between gastrointestinal schwannomas and GISTs using CT imaging.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Differentiation between gastrointestinal schwannomas and gastrointestinal stromal tumors by computed tomography

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