Open Access

Expression of PGC1α in glioblastoma multiforme patients

  • Authors:
    • Sang Yeon Cho
    • Seon‑Hwan Kim
    • Min‑Hee Yi
    • Enji Zhang
    • Eunjee Kim
    • Jisoo Park
    • Eun‑Kyeong Jo
    • Young Ho Lee
    • Min Soo Park
    • Yonghyun Kim
    • Jongsun Park
    • Dong Woon Kim
  • View Affiliations

  • Published online on: April 3, 2017     https://doi.org/10.3892/ol.2017.5972
  • Pages: 4055-4076
  • Copyright: © Cho et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Peroxisome proliferator-activated receptor γ coactivator 1α (PGC1α) is a key modulator of mitochondrial biogenesis. It is a coactivator of multiple transcription factors and regulates metabolic processes. However, little is known about the expression and function of PGC1α in glioblastoma multiforme (GBM), the most prevalent and invasive type of brain tumor. The purpose of the present study was to investigate the biological function, localization and expression of PGC1α in GBM. It was observed that PGC1α expression is increased in the tumor cells, and a higher level of expression was observed in the mitochondria. Bioinformatics analyses identified that metabolic and mitochondrial genes were highly expressed in GBM cells, with a high PGC1α mRNA expression. Notably, mitochondrial function-associated genes were highly expressed in cells alongside high PGC1α expression. Collectively, the results of the present study indicate that PGC1α is associated with mitochondrial dysfunction in GBM and may have a role in tumor pathogenesis and progression.
View Figures
View References

Related Articles

Journal Cover

June-2017
Volume 13 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Cho SY, Kim SH, Yi MH, Zhang E, Kim E, Park J, Jo EK, Lee YH, Park MS, Kim Y, Kim Y, et al: Expression of PGC1α in glioblastoma multiforme patients. Oncol Lett 13: 4055-4076, 2017
APA
Cho, S.Y., Kim, S., Yi, M., Zhang, E., Kim, E., Park, J. ... Kim, D.W. (2017). Expression of PGC1α in glioblastoma multiforme patients. Oncology Letters, 13, 4055-4076. https://doi.org/10.3892/ol.2017.5972
MLA
Cho, S. Y., Kim, S., Yi, M., Zhang, E., Kim, E., Park, J., Jo, E., Lee, Y. H., Park, M. S., Kim, Y., Park, J., Kim, D. W."Expression of PGC1α in glioblastoma multiforme patients". Oncology Letters 13.6 (2017): 4055-4076.
Chicago
Cho, S. Y., Kim, S., Yi, M., Zhang, E., Kim, E., Park, J., Jo, E., Lee, Y. H., Park, M. S., Kim, Y., Park, J., Kim, D. W."Expression of PGC1α in glioblastoma multiforme patients". Oncology Letters 13, no. 6 (2017): 4055-4076. https://doi.org/10.3892/ol.2017.5972