Epithelial-mesenchymal transition in cancer: Role of the IL-8/IL-8R axis (Review)

  • Authors:
    • Zhiwei Zhao
    • Shichao Wang
    • Yingbo Lin
    • Yali Miao
    • Ye Zeng
    • Yongmei Nie
    • Peng Guo
    • Guangyao Jiang
    • Jiang Wu
  • View Affiliations

  • Published online on: April 13, 2017     https://doi.org/10.3892/ol.2017.6034
  • Pages: 4577-4584
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Abstract

Epithelial-mesenchymal transition (EMT) is a biological process that is associated with cancer metastasis and invasion. In cancer, EMT promotes cell motility, invasion and distant metastasis. Interleukin (IL)-8 is highly expressed in tumors and may induce EMT. The IL‑8/IL‑8R axis has a vital role in EMT in carcinoma, which is regulated by several signaling pathways, including the transforming growth factor β‑spleen associated tyrosine kinase/Src-AKT/extracellular signal‑regulated kinase, p38/Jun N‑terminal kinase‑activating transcription factor‑2, phosphoinositide 3-kinase/AKT, nuclear factor-κB and Wnt signaling pathways. Blocking the IL‑8/IL‑8R signaling pathway may be a novel strategy to reduce metastasis and improve patient survival rates. This review will cover IL‑8‑IL‑8R signaling pathway in tumor epithelial-mesenchymal transition.
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June-2017
Volume 13 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhao Z, Wang S, Lin Y, Miao Y, Zeng Y, Nie Y, Guo P, Jiang G and Wu J: Epithelial-mesenchymal transition in cancer: Role of the IL-8/IL-8R axis (Review). Oncol Lett 13: 4577-4584, 2017
APA
Zhao, Z., Wang, S., Lin, Y., Miao, Y., Zeng, Y., Nie, Y. ... Wu, J. (2017). Epithelial-mesenchymal transition in cancer: Role of the IL-8/IL-8R axis (Review). Oncology Letters, 13, 4577-4584. https://doi.org/10.3892/ol.2017.6034
MLA
Zhao, Z., Wang, S., Lin, Y., Miao, Y., Zeng, Y., Nie, Y., Guo, P., Jiang, G., Wu, J."Epithelial-mesenchymal transition in cancer: Role of the IL-8/IL-8R axis (Review)". Oncology Letters 13.6 (2017): 4577-4584.
Chicago
Zhao, Z., Wang, S., Lin, Y., Miao, Y., Zeng, Y., Nie, Y., Guo, P., Jiang, G., Wu, J."Epithelial-mesenchymal transition in cancer: Role of the IL-8/IL-8R axis (Review)". Oncology Letters 13, no. 6 (2017): 4577-4584. https://doi.org/10.3892/ol.2017.6034