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Article Open Access

C59T mutation in exon 2 of monocytic leukemia‑associated antigen‑34 gene indicates a high risk of recurrence of acute myeloid leukemia

  • Authors:
    • Bo Lei
    • Yinxia Chen
    • Aili He
    • Jing Luo
    • Pengyu Zhang
    • Fuling Zhou
    • Jie Liu
    • Xin Meng
    • Jing Wang
    • Wanggang Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an, Shanxi 710004, P.R. China, Department of Neurology, 451 Hospital of People's Liberation Army, Xi'an, Shaanxi 710054, P.R. China
    Copyright: © Lei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 55-62
    |
    Published online on: May 2, 2017
       https://doi.org/10.3892/ol.2017.6110
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Abstract

Monocytic leukemia‑associated antigen‑34 (MLAA‑34) is a novel monocytic leukemia‑associated antigen and a candidate oncogene. The aim of the present study was to investigate the involvement of the MLAA‑34 gene in acute myeloid leukemia (AML). MLAA‑34 expression level, chromosome location, gene copy number and single nucleotide polymorphisms (SNPs) of 40 patients with AML and 5 healthy volunteers were analyzed by reverse transcription‑polymerase chain reaction, fluorescence in situ hybridization and DNA sequencing. The effects of MLAA‑34 mutation on overall survival (OS) and progression‑free survival (PFS) of patients with AML were also analyzed. MLAA‑34 was significantly upregulated in patients with AML when compared with volunteer controls, and this upregulation was associated with a C59T SNP site located in the second exon of MLAA‑34. MLAA‑34 was mapped to 13q14.2 and no translocation was observed in patients with AML. In addition, this SNP site is affinitive to the well‑known molecular markers of AML, including Fms‑like tyrosine kinase 3 and DNA methyltransferase 3A, as well as extramedullary lesions, periphery leukocyte numbers, remission and cytogenetic abnormalities of patients with AML. Patients with AML with MLAA‑34 C59T mutations had significantly shorter OS and PFS times compared with that of patients without C59T mutations. The present findings indicated that the MLAA‑34 C59T mutation was a high‑risk factor for recurrence of AML, and may be a candidate target for AML therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Lei B, Chen Y, He A, Luo J, Zhang P, Zhou F, Liu J, Meng X, Wang J, Zhang W, Zhang W, et al: C59T mutation in exon 2 of monocytic leukemia‑associated antigen‑34 gene indicates a high risk of recurrence of acute myeloid leukemia. Oncol Lett 14: 55-62, 2017.
APA
Lei, B., Chen, Y., He, A., Luo, J., Zhang, P., Zhou, F. ... Zhang, W. (2017). C59T mutation in exon 2 of monocytic leukemia‑associated antigen‑34 gene indicates a high risk of recurrence of acute myeloid leukemia. Oncology Letters, 14, 55-62. https://doi.org/10.3892/ol.2017.6110
MLA
Lei, B., Chen, Y., He, A., Luo, J., Zhang, P., Zhou, F., Liu, J., Meng, X., Wang, J., Zhang, W."C59T mutation in exon 2 of monocytic leukemia‑associated antigen‑34 gene indicates a high risk of recurrence of acute myeloid leukemia". Oncology Letters 14.1 (2017): 55-62.
Chicago
Lei, B., Chen, Y., He, A., Luo, J., Zhang, P., Zhou, F., Liu, J., Meng, X., Wang, J., Zhang, W."C59T mutation in exon 2 of monocytic leukemia‑associated antigen‑34 gene indicates a high risk of recurrence of acute myeloid leukemia". Oncology Letters 14, no. 1 (2017): 55-62. https://doi.org/10.3892/ol.2017.6110
Copy and paste a formatted citation
x
Spandidos Publications style
Lei B, Chen Y, He A, Luo J, Zhang P, Zhou F, Liu J, Meng X, Wang J, Zhang W, Zhang W, et al: C59T mutation in exon 2 of monocytic leukemia‑associated antigen‑34 gene indicates a high risk of recurrence of acute myeloid leukemia. Oncol Lett 14: 55-62, 2017.
APA
Lei, B., Chen, Y., He, A., Luo, J., Zhang, P., Zhou, F. ... Zhang, W. (2017). C59T mutation in exon 2 of monocytic leukemia‑associated antigen‑34 gene indicates a high risk of recurrence of acute myeloid leukemia. Oncology Letters, 14, 55-62. https://doi.org/10.3892/ol.2017.6110
MLA
Lei, B., Chen, Y., He, A., Luo, J., Zhang, P., Zhou, F., Liu, J., Meng, X., Wang, J., Zhang, W."C59T mutation in exon 2 of monocytic leukemia‑associated antigen‑34 gene indicates a high risk of recurrence of acute myeloid leukemia". Oncology Letters 14.1 (2017): 55-62.
Chicago
Lei, B., Chen, Y., He, A., Luo, J., Zhang, P., Zhou, F., Liu, J., Meng, X., Wang, J., Zhang, W."C59T mutation in exon 2 of monocytic leukemia‑associated antigen‑34 gene indicates a high risk of recurrence of acute myeloid leukemia". Oncology Letters 14, no. 1 (2017): 55-62. https://doi.org/10.3892/ol.2017.6110
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