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Article

Cholangiocarcinoma following external beam radiotherapy: A report of two cases

  • Authors:
    • Anisha Kulkarni
    • Justin S. Gundara
    • Anthony J. Gill
    • Thomas J. Hugh
    • Jaswinder S. Samra
  • View Affiliations / Copyright

    Affiliations: Upper Gastrointestinal Surgical Unit, Royal North Shore Hospital, University of Sydney, St. Leonards, Sydney, NSW 2065, Australia, Department of Anatomical Pathology, Royal North Shore Hospital, University of Sydney, St. Leonards, Sydney, NSW 2065, Australia
  • Pages: 423-426
    |
    Published online on: May 3, 2017
       https://doi.org/10.3892/ol.2017.6113
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Abstract

Cholangiocarcinoma (CCA) is a relatively rare primary malignancy, with established risk factors that include primary sclerosing cholangitis, choledochal cysts and hepatolithiasis. In the present study, two cases of CCA, which occurred following abdominal external beam radiotherapy (EBRT) for non‑Hodgkin's lymphoma, are reported. Case 1 and 2 were diagnosed with cholangiocarcinoma 30 and 4 years following treatment with combined chemotherapy and abdominal radiotherapy treatment, respectively. The patients received chemotherapy as treatment of cholangiocarcinoma; however, whilst their symptoms improved, they succumbed within 12 and 2 months respectively following the diagnosis with cholangiocarcinoma. Currently, the association between radiation exposure and hepatobiliary malignancy remains unclear, however, we hypothesize that biliary epithelium sensitivity to ionizing radiation may have contributed to the etiology of the secondary malignancies observed in these two patients. This study indicates that patients treated with abdominal EBRT may benefit from a heightened index of suspicion and more intensive surveillance for secondary biliary malignancies.
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Copy and paste a formatted citation
Spandidos Publications style
Kulkarni A, Gundara JS, Gill AJ, Hugh TJ and Samra JS: Cholangiocarcinoma following external beam radiotherapy: A report of two cases. Oncol Lett 14: 423-426, 2017.
APA
Kulkarni, A., Gundara, J.S., Gill, A.J., Hugh, T.J., & Samra, J.S. (2017). Cholangiocarcinoma following external beam radiotherapy: A report of two cases. Oncology Letters, 14, 423-426. https://doi.org/10.3892/ol.2017.6113
MLA
Kulkarni, A., Gundara, J. S., Gill, A. J., Hugh, T. J., Samra, J. S."Cholangiocarcinoma following external beam radiotherapy: A report of two cases". Oncology Letters 14.1 (2017): 423-426.
Chicago
Kulkarni, A., Gundara, J. S., Gill, A. J., Hugh, T. J., Samra, J. S."Cholangiocarcinoma following external beam radiotherapy: A report of two cases". Oncology Letters 14, no. 1 (2017): 423-426. https://doi.org/10.3892/ol.2017.6113
Copy and paste a formatted citation
x
Spandidos Publications style
Kulkarni A, Gundara JS, Gill AJ, Hugh TJ and Samra JS: Cholangiocarcinoma following external beam radiotherapy: A report of two cases. Oncol Lett 14: 423-426, 2017.
APA
Kulkarni, A., Gundara, J.S., Gill, A.J., Hugh, T.J., & Samra, J.S. (2017). Cholangiocarcinoma following external beam radiotherapy: A report of two cases. Oncology Letters, 14, 423-426. https://doi.org/10.3892/ol.2017.6113
MLA
Kulkarni, A., Gundara, J. S., Gill, A. J., Hugh, T. J., Samra, J. S."Cholangiocarcinoma following external beam radiotherapy: A report of two cases". Oncology Letters 14.1 (2017): 423-426.
Chicago
Kulkarni, A., Gundara, J. S., Gill, A. J., Hugh, T. J., Samra, J. S."Cholangiocarcinoma following external beam radiotherapy: A report of two cases". Oncology Letters 14, no. 1 (2017): 423-426. https://doi.org/10.3892/ol.2017.6113
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