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Case Report Open Access

Pancreatic intraductal tubulopapillary neoplasm with associated invasive cancer successfully treated by total pancreatectomy: A case report

  • Authors:
    • Yuji Fujimoto
    • Yoshito Tomimaru
    • Hiromi Tamura
    • Kozo Noguchi
    • Hirotsugu Nagase
    • Atsushi Hamabe
    • Masashi Hirota
    • Kazuteru Oshima
    • Tsukasa Tanida
    • Tomono Kawase
    • Shunji Morita
    • Hiroshi Imamura
    • Takashi Iwazawa
    • Kenzo Akagi
    • Masashi Yamamoto
    • Tsutomu Nishida
    • Shiro Adachi
    • Keizo Dono
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Toyonaka Municipal Hospital, Toyonaka, Osaka 560‑8565, Japan, Department of Pathology, Toyonaka Municipal Hospital, Toyonaka, Osaka 560‑8565, Japan, Department of Gastroenterology, Toyonaka Municipal Hospital, Toyonaka, Osaka 560‑8565, Japan
    Copyright: © Fujimoto et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 153-158
    |
    Published online on: May 5, 2017
       https://doi.org/10.3892/ol.2017.6130
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Abstract

A 74‑year‑old male was admitted to Departments of Surgery, Toyonaka Municipal Hospital (Osaka, Japan) for treatment of a pancreatic tumor. Contrast enhanced computed tomography (CT) revealed a mass with small cystic lesions in the pancreatic head and body. Fluorodeoxyglucose‑positron emission tomography/CT revealed an abnormal uptake of fluorodeoxyglucose, corresponding to the mass lesions. Upper gastrointestinal endoscopy revealed rough mucosa near the opening of the accessory pancreatic duct, and the mucosa biopsy exhibited adenocarcinoma with no mucin observed. The preoperative diagnosis was pancreatic intraductal tubulopapillary neoplasm (ITPN) with cancerous lesions, and a total pancreatectomy with splenectomy was performed. The resected tissue specimen revealed a solid tumor occupying the entire pancreas with intraductal growth into the main pancreatic duct. Histological examination revealed high‑grade dysplastic cells in a tubulopapillary growth pattern without overt mucin production beyond the pancreatic duct. Immunohistochemical staining analysis of the tumor was positive for cytokeratin (CK)7, CK19 and mucin (MUC)1, and negative for MUC2, MUC5AC, MUC6 and caudal type homeobox 2. The tumor was finally diagnosed as pancreatic ITPN with associated invasive cancer. The patient remains well without evident recurrence nine months post‑surgery. ITPN is a rare type of epithelial neoplasm of the pancreas, and is characterized by intraductal tubulo‑papillary growth, ductal differentiation, limited intracellular mucin production, and cellular dysplasia. The present case report may contribute to improved understanding of how to effectively treat patients with ITPN.
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Copy and paste a formatted citation
Spandidos Publications style
Fujimoto Y, Tomimaru Y, Tamura H, Noguchi K, Nagase H, Hamabe A, Hirota M, Oshima K, Tanida T, Kawase T, Kawase T, et al: Pancreatic intraductal tubulopapillary neoplasm with associated invasive cancer successfully treated by total pancreatectomy: A case report. Oncol Lett 14: 153-158, 2017.
APA
Fujimoto, Y., Tomimaru, Y., Tamura, H., Noguchi, K., Nagase, H., Hamabe, A. ... Dono, K. (2017). Pancreatic intraductal tubulopapillary neoplasm with associated invasive cancer successfully treated by total pancreatectomy: A case report. Oncology Letters, 14, 153-158. https://doi.org/10.3892/ol.2017.6130
MLA
Fujimoto, Y., Tomimaru, Y., Tamura, H., Noguchi, K., Nagase, H., Hamabe, A., Hirota, M., Oshima, K., Tanida, T., Kawase, T., Morita, S., Imamura, H., Iwazawa, T., Akagi, K., Yamamoto, M., Nishida, T., Adachi, S., Dono, K."Pancreatic intraductal tubulopapillary neoplasm with associated invasive cancer successfully treated by total pancreatectomy: A case report". Oncology Letters 14.1 (2017): 153-158.
Chicago
Fujimoto, Y., Tomimaru, Y., Tamura, H., Noguchi, K., Nagase, H., Hamabe, A., Hirota, M., Oshima, K., Tanida, T., Kawase, T., Morita, S., Imamura, H., Iwazawa, T., Akagi, K., Yamamoto, M., Nishida, T., Adachi, S., Dono, K."Pancreatic intraductal tubulopapillary neoplasm with associated invasive cancer successfully treated by total pancreatectomy: A case report". Oncology Letters 14, no. 1 (2017): 153-158. https://doi.org/10.3892/ol.2017.6130
Copy and paste a formatted citation
x
Spandidos Publications style
Fujimoto Y, Tomimaru Y, Tamura H, Noguchi K, Nagase H, Hamabe A, Hirota M, Oshima K, Tanida T, Kawase T, Kawase T, et al: Pancreatic intraductal tubulopapillary neoplasm with associated invasive cancer successfully treated by total pancreatectomy: A case report. Oncol Lett 14: 153-158, 2017.
APA
Fujimoto, Y., Tomimaru, Y., Tamura, H., Noguchi, K., Nagase, H., Hamabe, A. ... Dono, K. (2017). Pancreatic intraductal tubulopapillary neoplasm with associated invasive cancer successfully treated by total pancreatectomy: A case report. Oncology Letters, 14, 153-158. https://doi.org/10.3892/ol.2017.6130
MLA
Fujimoto, Y., Tomimaru, Y., Tamura, H., Noguchi, K., Nagase, H., Hamabe, A., Hirota, M., Oshima, K., Tanida, T., Kawase, T., Morita, S., Imamura, H., Iwazawa, T., Akagi, K., Yamamoto, M., Nishida, T., Adachi, S., Dono, K."Pancreatic intraductal tubulopapillary neoplasm with associated invasive cancer successfully treated by total pancreatectomy: A case report". Oncology Letters 14.1 (2017): 153-158.
Chicago
Fujimoto, Y., Tomimaru, Y., Tamura, H., Noguchi, K., Nagase, H., Hamabe, A., Hirota, M., Oshima, K., Tanida, T., Kawase, T., Morita, S., Imamura, H., Iwazawa, T., Akagi, K., Yamamoto, M., Nishida, T., Adachi, S., Dono, K."Pancreatic intraductal tubulopapillary neoplasm with associated invasive cancer successfully treated by total pancreatectomy: A case report". Oncology Letters 14, no. 1 (2017): 153-158. https://doi.org/10.3892/ol.2017.6130
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