Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July-2017 Volume 14 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2017 Volume 14 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Metastases of transverse colon cancer to bilateral ovaries (Krukenberg tumor) and the left breast: A case report

  • Authors:
    • Xin‑Yu Luo
    • Jue Wang
    • Jia Zhao
    • Rui Chen
    • Xiao‑Ming Zha
  • View Affiliations / Copyright

    Affiliations: Department of Breast Disease, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China
    Copyright: © Luo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 31-34
    |
    Published online on: May 11, 2017
       https://doi.org/10.3892/ol.2017.6158
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Breast cancer has the highest rate of incidence among all types of cancer in women. Only ~0.43% of breast malignancies occur as a result of metastatic lesions from extramammary tumors. The present study reports an extremely rare case of transverse colon cancer metastasizing to the bilateral ovaries and the left breast. The patient was a 47-year old female, who had a lump in the left breast without axillary lymphadenopathy. Specimens obtained by core needle biopsy were submitted for hematoxylin and eosin examination, and results revealed that the lump was a poorly differentiated adenocarcinoma. Since the patient had elevated levels of the carcinoembryonic antigen and a medical history of a Krukenberg tumor metastasized from colon cancer, immunohistochemical examinations were applied. Results identified that caudal‑related homeobox protein 2 and cytokeratin 20 were positively stained, whilst cytokeratin 7 was negatively stained. Therefore, this patient was diagnosed as having colon cancer that had metastasized to the bilateral ovaries and the left breast. As the life expectancy of patients with cancer is increasing, types of metastases that used to be seen as rare are increasingly becoming more common. For clinicians, diagnosis should be cautious, and differential diagnosis should always be kept in mind.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2015. CA Cancer J Clin. 65:5–29. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Georgiannos SN, Chin J, Goode AW and Sheaff M: Secondary neoplasms of the breast: A survey of the 20th century. Cancer. 92:2259–2266. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Ahmad A, Baiden-Amissah K, Oyegade A, Absar M, Swainson K and Titi S: Primary sigmoid adenocarcinoma metastasis to the breast in a 28-year-old female: A case study and a review of literature. Korean J Pathol. 48:58–61. 2014. View Article : Google Scholar : PubMed/NCBI

4 

McIntosh IH, Hooper AA, Millis RR and Greening WP: Metastatic carcinoma within the breast. Clin Oncol. 2:393–401. 1976.PubMed/NCBI

5 

Mendelson E, Bohm-Velez M, Berg W, et al: ACR BI-RADS® ultrasoundAtlas, Breast Imaging Reporting and Data System American College of Radiology. Reston VA: pp. 1492013

6 

Selcukbiricik F, Tural D, Bay A, Sahingoz G, Ilvan S and Mandel NM: A malignant mass in the breast is not always breast cancer. Case Rep Oncol. 4:521–525. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Israel SL, Helsel EV Jr and Hausman DH: The challenge of metastatic ovarian carcinoma. Am J Obstet Gynecol. 93:1094–1101. 1965. View Article : Google Scholar : PubMed/NCBI

8 

Jiang R, Tang J, Cheng X and Zang RY: Surgical treatment for patients with different origins of Krukenberg tumors: Outcomes and prognostic factors. Eur J Surg Oncol. 35:92–97. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Jiang Q, Liu S, Xiong H, Pen J, Cai K, Yang Y and Xiong Z: Metastatic signet ring cell carcinoma of the bilateral breasts and ovaries from gastrointestinal tract in a young breastfeeding female - a case report. J Cancer. 2:484–489. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Vakili SM, Sharbatdaran M, Noorbaran A, Siadati S, Moslemi D and Shafahi S: A case of colon cancer with breast metastasis and krukenberg tumor. Int J Hematol Oncol Stem Cell Res. 8:46–50. 2014.PubMed/NCBI

11 

Noh KT, Oh B, Sung SH, Lee RA, Chung SS, Moon BI and Kim KH: Metastasis to the breast from colonic adenocarcinoma. J Korean Surg Soc. 81 Suppl 1:S43–S46. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Fernández de Bobadilla L, García Villanueva A, Collado M, De Juan A, Rojo R, Pérez J, Lisa E, Aguilera A, Mena A and González-Palacios F: Breast metastasis of primary colon cancer. Rev Esp Enferm Dig. 96:415–419. 2004.(In English, Spanish). View Article : Google Scholar : PubMed/NCBI

13 

Vergier B, Trojani M, De Mascarel I, Coindre JM and Le Treut A: Metastases to the breast: Differential diagnosis from primary breast carcinoma. J Surg Oncol. 48:112–116. 1991. View Article : Google Scholar : PubMed/NCBI

14 

Hajdu SI and Urban JA: Cancers metastatic to the breast. Cancer. 29:1691–1696. 1972. View Article : Google Scholar : PubMed/NCBI

15 

Williams SA, Ehlers RA II, Hunt KK, Yi M, Kuerer HM, Singletary SE, Ross MI, Feig BW, Symmans WF and Meric-Bernstam F: Metastases to the breast from nonbreast solid neoplasms: Presentation and determinants of survival. Cancer. 110:731–737. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Vizcaino I, Torregrosa A, Higueras V, Morote V, Cremades A, Torres V, Olmos S and Molins C: Metastasis to the breast from extramammary malignancies: A report of four cases and a review of literature. Eur Radiol. 11:1659–1665. 2011. View Article : Google Scholar

17 

Ho YY and Lee WK: Metastasis to the breast from an adenocarcinoma of the colon. J Clin Ultrasound. 37:239–241. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Kende AI, Carr NJ and Sobin LH: Expression of cytokeratins 7 and 20 in carcinomas of the gastrointestinal tract. Histopathology. 42:137–140. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Park SY, Kim BH, Kim JH, Lee S and Kang GH: Panels of immunohistochemical markers help determine primary sites of metastatic adenocarcinoma. Arch Pathol Lab Med. 131:1561–1567. 2007.PubMed/NCBI

20 

Werling RW, Yaziji H, Bacchi CE and Gown AM: CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin: An immunohistochemical survey of 476 primary and metastatic carcinomas. Am J Surg Pathol. 27:303–310. 2003. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Luo XY, Wang J, Zhao J, Chen R and Zha XM: Metastases of transverse colon cancer to bilateral ovaries (Krukenberg tumor) and the left breast: A case report. Oncol Lett 14: 31-34, 2017.
APA
Luo, X., Wang, J., Zhao, J., Chen, R., & Zha, X. (2017). Metastases of transverse colon cancer to bilateral ovaries (Krukenberg tumor) and the left breast: A case report. Oncology Letters, 14, 31-34. https://doi.org/10.3892/ol.2017.6158
MLA
Luo, X., Wang, J., Zhao, J., Chen, R., Zha, X."Metastases of transverse colon cancer to bilateral ovaries (Krukenberg tumor) and the left breast: A case report". Oncology Letters 14.1 (2017): 31-34.
Chicago
Luo, X., Wang, J., Zhao, J., Chen, R., Zha, X."Metastases of transverse colon cancer to bilateral ovaries (Krukenberg tumor) and the left breast: A case report". Oncology Letters 14, no. 1 (2017): 31-34. https://doi.org/10.3892/ol.2017.6158
Copy and paste a formatted citation
x
Spandidos Publications style
Luo XY, Wang J, Zhao J, Chen R and Zha XM: Metastases of transverse colon cancer to bilateral ovaries (Krukenberg tumor) and the left breast: A case report. Oncol Lett 14: 31-34, 2017.
APA
Luo, X., Wang, J., Zhao, J., Chen, R., & Zha, X. (2017). Metastases of transverse colon cancer to bilateral ovaries (Krukenberg tumor) and the left breast: A case report. Oncology Letters, 14, 31-34. https://doi.org/10.3892/ol.2017.6158
MLA
Luo, X., Wang, J., Zhao, J., Chen, R., Zha, X."Metastases of transverse colon cancer to bilateral ovaries (Krukenberg tumor) and the left breast: A case report". Oncology Letters 14.1 (2017): 31-34.
Chicago
Luo, X., Wang, J., Zhao, J., Chen, R., Zha, X."Metastases of transverse colon cancer to bilateral ovaries (Krukenberg tumor) and the left breast: A case report". Oncology Letters 14, no. 1 (2017): 31-34. https://doi.org/10.3892/ol.2017.6158
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team