Withaferin A inhibits the proliferation of gastric cancer cells by inducing G2/M cell cycle arrest and apoptosis

  • Authors:
    • Green Kim
    • Tae‑Hyoun Kim
    • Eun‑Ha Hwang
    • Kyu‑Tae Chang
    • Jung Joo Hong
    • Jong‑Hwan Park
  • View Affiliations

  • Published online on: May 12, 2017     https://doi.org/10.3892/ol.2017.6169
  • Pages: 416-422
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Abstract

Human gastric adenocarcinoma (AGS) is one of the most common types of malignant tumor and the third‑leading cause of tumor‑associated mortality worldwide. Withaferin A (WA), a steroidal lactone derived from Withania somnifera, exhibits antitumor activity in a variety of cancer models. However, to the best of our knowledge, the direct effect of WA on AGS cells has not previously been determined. The present study investigated the effects of WA on the proliferation and metastatic activity of AGS cells. WA exerted a dose‑dependent cytotoxic effect on AGS cells. The effect was associated with cell cycle arrest at the G2/M phase and the expression of apoptotic proteins. Additionally, WA treatment resulted in a decrease in the migration and invasion ability of the AGS cells, as demonstrated using a wound healing assay and a Boyden chamber assay. These results indicate that WA directly inhibits the proliferation and metastatic activity of gastric cancer cells, and suggest that WA may be developed as a drug for the treatment of gastric cancer.
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July-2017
Volume 14 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Kim G, Kim TH, Hwang EH, Chang KT, Hong JJ and Park H: Withaferin A inhibits the proliferation of gastric cancer cells by inducing G2/M cell cycle arrest and apoptosis. Oncol Lett 14: 416-422, 2017
APA
Kim, G., Kim, T., Hwang, E., Chang, K., Hong, J.J., & Park, . (2017). Withaferin A inhibits the proliferation of gastric cancer cells by inducing G2/M cell cycle arrest and apoptosis. Oncology Letters, 14, 416-422. https://doi.org/10.3892/ol.2017.6169
MLA
Kim, G., Kim, T., Hwang, E., Chang, K., Hong, J. J., Park, ."Withaferin A inhibits the proliferation of gastric cancer cells by inducing G2/M cell cycle arrest and apoptosis". Oncology Letters 14.1 (2017): 416-422.
Chicago
Kim, G., Kim, T., Hwang, E., Chang, K., Hong, J. J., Park, ."Withaferin A inhibits the proliferation of gastric cancer cells by inducing G2/M cell cycle arrest and apoptosis". Oncology Letters 14, no. 1 (2017): 416-422. https://doi.org/10.3892/ol.2017.6169