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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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November-2017 Volume 14 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Case Report

How to detect the rare BCR‑ABL (e14a3) transcript: A case report and literature review

  • Authors:
    • Lin‑Hui Hu
    • Lian‑Fang Pu
    • Dong‑Dong Yang
    • Cui Zhang
    • Hui‑Ping Wang
    • Yang‑Yang Ding
    • Man‑Man Li
    • Zhi‑Min Zhai
    • Shudao Xiong
  • View Affiliations / Copyright

    Affiliations: Hematological Lab, Department of Hematology, The Second Hospital of Anhui Medical University, Hefei, Anhui 230601, P.R. China
  • Pages: 5619-5623
    |
    Published online on: August 28, 2017
       https://doi.org/10.3892/ol.2017.6847
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Abstract

The Philadelphia (Ph; BCR‑ABL) chromosome originates from a translocation event between chromosomes 9 and 22, and results in the BCR‑ABL fusion gene. In chronic myelogenous leukemia (CML), the BCR‑ABL gene is mainly coded for by a major breakpoint cluster region (M‑bcr, e13a2 and e14a2). However, in some patients, BCR‑ABL genes are encoded by a minor (m)‑bcr, e1a2, and a micro (µ)‑bcr region, e19a2. These transcripts revealed a different clinical course. The present study described a CML patient whose cytogenetics and FISH analyses of bone marrow revealed a karyotype of 46, XY t(9,22) (q34;q11), while the commercial kits of quantitative PCR (qPCR) failed to detect the BCR‑ABL fusion gene. Further multiplex Reverse transcription‑PCR (RT‑PCR) and sequencing analyses identified a rare e14a3 (b3a3) fusion transcript.
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Copy and paste a formatted citation
Spandidos Publications style
Hu LH, Pu LF, Yang DD, Zhang C, Wang HP, Ding YY, Li MM, Zhai ZM and Xiong S: How to detect the rare BCR‑ABL (e14a3) transcript: A case report and literature review. Oncol Lett 14: 5619-5623, 2017.
APA
Hu, L., Pu, L., Yang, D., Zhang, C., Wang, H., Ding, Y. ... Xiong, S. (2017). How to detect the rare BCR‑ABL (e14a3) transcript: A case report and literature review. Oncology Letters, 14, 5619-5623. https://doi.org/10.3892/ol.2017.6847
MLA
Hu, L., Pu, L., Yang, D., Zhang, C., Wang, H., Ding, Y., Li, M., Zhai, Z., Xiong, S."How to detect the rare BCR‑ABL (e14a3) transcript: A case report and literature review". Oncology Letters 14.5 (2017): 5619-5623.
Chicago
Hu, L., Pu, L., Yang, D., Zhang, C., Wang, H., Ding, Y., Li, M., Zhai, Z., Xiong, S."How to detect the rare BCR‑ABL (e14a3) transcript: A case report and literature review". Oncology Letters 14, no. 5 (2017): 5619-5623. https://doi.org/10.3892/ol.2017.6847
Copy and paste a formatted citation
x
Spandidos Publications style
Hu LH, Pu LF, Yang DD, Zhang C, Wang HP, Ding YY, Li MM, Zhai ZM and Xiong S: How to detect the rare BCR‑ABL (e14a3) transcript: A case report and literature review. Oncol Lett 14: 5619-5623, 2017.
APA
Hu, L., Pu, L., Yang, D., Zhang, C., Wang, H., Ding, Y. ... Xiong, S. (2017). How to detect the rare BCR‑ABL (e14a3) transcript: A case report and literature review. Oncology Letters, 14, 5619-5623. https://doi.org/10.3892/ol.2017.6847
MLA
Hu, L., Pu, L., Yang, D., Zhang, C., Wang, H., Ding, Y., Li, M., Zhai, Z., Xiong, S."How to detect the rare BCR‑ABL (e14a3) transcript: A case report and literature review". Oncology Letters 14.5 (2017): 5619-5623.
Chicago
Hu, L., Pu, L., Yang, D., Zhang, C., Wang, H., Ding, Y., Li, M., Zhai, Z., Xiong, S."How to detect the rare BCR‑ABL (e14a3) transcript: A case report and literature review". Oncology Letters 14, no. 5 (2017): 5619-5623. https://doi.org/10.3892/ol.2017.6847
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