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Mammalian sterile 20‑like kinase 1 expression and its prognostic significance in patients with breast cancer

  • Authors:
    • Xiao‑Yan Lin
    • Feng‑Feng Cai
    • Ming‑Hong Wang
    • Xin Pan
    • Fang Wang
    • Lu Cai
    • Rong‑Rong Cui
    • Su Chen
    • Ewelina Biskup
  • View Affiliations / Copyright

    Affiliations: Department of Breast Surgery, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, P.R. China, Department of Cardiology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, P.R. China, Central Laboratory, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, P.R. China, Department of Pharmacy, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, P.R. China, Department of Molecular and Cellular Biology, School of Forensic Sciences, Xi'an Jiao Tong University Health Science Center, Xi'an, Shaanxi 710061, P.R. China, Department of Internal Medicine, University Hospital of Basel, Basel 4031, Switzerland
    Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5457-5463
    |
    Published online on: August 28, 2017
       https://doi.org/10.3892/ol.2017.6852
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Abstract

Mammalian sterile 20‑like kinase 1 (Mst1) is a major inhibitor of cell proliferation, and is involved in apoptosis, oncogenesis and organ growth via its ubiquitously encoded serine threonine kinase. Previous studies have demonstrated that Mst1 has a tumor suppressor function in human breast cancer. Mst1 deletion or mutation is associated with tumorigenesis, whereas Mst1 overexpression leads to tumor cell apoptosis and decreases proliferation of tumor cells. Our previous study reported the tumor suppressive function of Mst1, and debated Mst1 as a prognostic factor in human breast cancer. In the present study, Mst1 levels were measured in the plasma of patients in order to elucidate their association with overall and disease‑free survival. The results of the present study indicated that Mst1 is a strong prognostic and predictive factor in human breast cancer and a promising anticancer target.
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Copy and paste a formatted citation
Spandidos Publications style
Lin XY, Cai FF, Wang MH, Pan X, Wang F, Cai L, Cui RR, Chen S and Biskup E: Mammalian sterile 20‑like kinase 1 expression and its prognostic significance in patients with breast cancer. Oncol Lett 14: 5457-5463, 2017.
APA
Lin, X., Cai, F., Wang, M., Pan, X., Wang, F., Cai, L. ... Biskup, E. (2017). Mammalian sterile 20‑like kinase 1 expression and its prognostic significance in patients with breast cancer. Oncology Letters, 14, 5457-5463. https://doi.org/10.3892/ol.2017.6852
MLA
Lin, X., Cai, F., Wang, M., Pan, X., Wang, F., Cai, L., Cui, R., Chen, S., Biskup, E."Mammalian sterile 20‑like kinase 1 expression and its prognostic significance in patients with breast cancer". Oncology Letters 14.5 (2017): 5457-5463.
Chicago
Lin, X., Cai, F., Wang, M., Pan, X., Wang, F., Cai, L., Cui, R., Chen, S., Biskup, E."Mammalian sterile 20‑like kinase 1 expression and its prognostic significance in patients with breast cancer". Oncology Letters 14, no. 5 (2017): 5457-5463. https://doi.org/10.3892/ol.2017.6852
Copy and paste a formatted citation
x
Spandidos Publications style
Lin XY, Cai FF, Wang MH, Pan X, Wang F, Cai L, Cui RR, Chen S and Biskup E: Mammalian sterile 20‑like kinase 1 expression and its prognostic significance in patients with breast cancer. Oncol Lett 14: 5457-5463, 2017.
APA
Lin, X., Cai, F., Wang, M., Pan, X., Wang, F., Cai, L. ... Biskup, E. (2017). Mammalian sterile 20‑like kinase 1 expression and its prognostic significance in patients with breast cancer. Oncology Letters, 14, 5457-5463. https://doi.org/10.3892/ol.2017.6852
MLA
Lin, X., Cai, F., Wang, M., Pan, X., Wang, F., Cai, L., Cui, R., Chen, S., Biskup, E."Mammalian sterile 20‑like kinase 1 expression and its prognostic significance in patients with breast cancer". Oncology Letters 14.5 (2017): 5457-5463.
Chicago
Lin, X., Cai, F., Wang, M., Pan, X., Wang, F., Cai, L., Cui, R., Chen, S., Biskup, E."Mammalian sterile 20‑like kinase 1 expression and its prognostic significance in patients with breast cancer". Oncology Letters 14, no. 5 (2017): 5457-5463. https://doi.org/10.3892/ol.2017.6852
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