Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November-2017 Volume 14 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2017 Volume 14 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Research progress on circadian clock genes in common abdominal malignant tumors (Review)

  • Authors:
    • Sheng‑Li Yang
    • Quan‑Guang Ren
    • Lu Wen
    • Jian‑Li Hu
    • Heng‑Yi Wang
  • View Affiliations / Copyright

    Affiliations: Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, P.R. China, Department of Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5091-5098
    |
    Published online on: August 31, 2017
       https://doi.org/10.3892/ol.2017.6856
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The circadian clock refers to the inherent biological rhythm of an organism, which, is accurately regulated by numerous clock genes. Studies in recent years have reported that the abnormal expression of clock genes is ubiquitous in common abdominal malignant tumors, including liver, colorectal, gastric and pancreatic cancer. In addition, the abnormal expression of certain clock genes is closely associated with clinical tumor parameters or patient prognosis. Studies in clock genes may expand the knowledge about the mechanism of occurrence and development of tumors, and may provide a new approach for tumor therapy. The present study summarizes the research progress in this field.
View Figures

Figure 1

View References

1 

Montenegro-Montero A, Canessa P and Larrondo LF: Around the fungal clock: Recent advances in the molecular study of circadian clocks in neurospora and other fungi. Adv Genet. 92:107–184. 2015.PubMed/NCBI

2 

Endo M: Tissue-specific circadian clocks in plants. Curr Opin Plant Biol. 29:44–49. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Di Cara F and King-Jones K: How clocks and hormones act in concert to control the timing of insect development. Curr Top Dev Biol. 105:1–36. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Tomioka K: Chronobiology of crickets: A review. Zoolog Sci. 31:624–632. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Numata H, Miyazaki Y and Ikeno T: Common features in diverse insect clocks. Zoological Lett. 1:102015. View Article : Google Scholar : PubMed/NCBI

6 

Uryu O, Ameku T and Niwa R: Recent progress in understanding the role of ecdysteroids in adult insects: Germline development and circadian clock in the fruit fly Drosophila melanogaster. Zoological Lett. 1:322015. View Article : Google Scholar : PubMed/NCBI

7 

Heller HC and Ruby NF: Sleep and circadian rhythms in mammalian torpor. Annu Rev Physiol. 66:275–289. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Ruby NF: Hibernation: When good clocks go cold. J Biol Rhythms. 18:275–286. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Coomans CP, Ramkisoensing A and Meijer JH: The suprachiasmatic nuclei as a seasonal clock. Front Neuroendocrinol. 37:29–42. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Leslie M: Circadian rhythms. Sleep study suggests triggers for diabetes and obesity. Science. 336:1432012. View Article : Google Scholar : PubMed/NCBI

11 

Bass J: Circadian topology of metabolism. Nature. 491:348–356. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Richards J, Diaz AN and Gumz ML: Clock genes in hypertension: Novel insights from rodent models. Blood Press Monit. 19:249–254. 2014. View Article : Google Scholar : PubMed/NCBI

13 

McLoughlin SC, Haines P and FitzGerald GA: Clocks and cardiovascular function. Methods Enzymol. 552:211–228. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Robinson I and Reddy AB: Molecular mechanisms of the circadian clockwork in mammals. FEBS Lett. 588:2477–2483. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Li S and Zhang L: Circadian control of global transcription. Biomed Res Int. 2015:1878092015. View Article : Google Scholar : PubMed/NCBI

16 

Huang N, Chelliah Y, Shan Y, Taylor CA, Yoo SH, Partch C, Green CB, Zhang H and Takahashi JS: Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex. Science. 337:189–194. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Cho H, Zhao X, Hatori M, Yu RT, Barish GD, Lam MT, Chong LW, DiTacchio L, Atkins AR, Glass CK, et al: Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β. Nature. 485:123–127. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Bersten DC, Sullivan AE, Peet DJ and Whitelaw ML: bHLH-PAS proteins in cancer. Nat Rev Cancer. 13:827–841. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Mazzoccoli G, Pazienza V and Vinciguerra M: Clock genes and clock-controlled genes in the regulation of metabolic rhythms. Chronobiol Int. 29:227–251. 2012. View Article : Google Scholar : PubMed/NCBI

20 

King DP, Zhao Y, Sangoram AM, Wilsbacher LD, Tanaka M, Antoch MP, Steeves TD, Vitaterna MH, Kornhauser JM, Lowrey PL, et al: Positional cloning of the mouse circadian clock gene. Cell. 89:641–653. 1997. View Article : Google Scholar : PubMed/NCBI

21 

Steeves TD, King DP, Zhao Y, Sangoram AM, Du F, Bowcock AM, Moore RY and Takahashi JS: Molecular cloning and characterization of the human CLOCK gene: Expression in the suprachiasmatic nuclei. Genomics. 57:189–200. 1999. View Article : Google Scholar : PubMed/NCBI

22 

Naylor E, Bergmann BM, Krauski K, Zee PC, Takahashi JS, Vitaterna MH and Turek FW: The circadian clock mutation alters sleep homeostasis in the mouse. J Neurosci. 20:8138–8143. 2000.PubMed/NCBI

23 

Lee J, Lee S, Chung S, Park N, Son GH, An H, Jang J, Chang DJ, Suh YG and Kim K: Identification of a novel circadian clock modulator controlling BMAL1 expression through a ROR/REV-ERB-response element-dependent mechanism. Biochem Biophys Res Commun. 469:580–586. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Ikeda M and Nomura M: cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS protein (BMAL1) and identification of alternatively spliced variants with alternative translation initiation site usage. Biochem Biophys Res Commun. 233:258–264. 1997. View Article : Google Scholar : PubMed/NCBI

25 

Bunger MK, Wilsbacher LD, Moran SM, Clendenin C, Radcliffe LA, Hogenesch JB, Simon MC, Takahashi JS and Bradfield CA: Mop3 is an essential component of the master circadian pacemaker in mammals. Cell. 103:1009–1017. 2000. View Article : Google Scholar : PubMed/NCBI

26 

Young ME, Brewer RA, Peliciari-Garcia RA, Collins HE, He L, Birky TL, Peden BW, Thompson EG, Ammons BJ, Bray MS, et al: Cardiomyocyte-specific BMAL1 plays critical roles in metabolism, signaling, and maintenance of contractile function of the heart. J Biol Rhythms. 29:257–276. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Kennaway DJ, Varcoe TJ, Voultsios A and Boden MJ: Global loss of bmal1 expression alters adipose tissue hormones, gene expression and glucose metabolism. PLoS One. 8:e652552013. View Article : Google Scholar : PubMed/NCBI

28 

Rudic RD, McNamara P, Curtis AM, Boston RC, Panda S, Hogenesch JB and Fitzgerald GA: BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis. PLoS Biol. 2:e3772004. View Article : Google Scholar : PubMed/NCBI

29 

Khapre RV, Kondratova AA, Patel S, Dubrovsky Y, Wrobel M, Antoch MP and Kondratov RV: BMAL1-dependent regulation of the mTOR signaling pathway delays aging. Aging (Albany NY). 6:48–57. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Ali AA, Schwarz-Herzke B, Stahr A, Prozorovski T, Aktas O and von Gall C: Premature aging of the hippocampal neurogenic niche in adult Bmal1-deficient mice. Aging (Albany NY). 7:435–449. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Konopka RJ and Benzer S: Clock mutants of Drosophila melanogaster. Proc Natl Acad Sci USA. 68:2112–2116. 1971. View Article : Google Scholar : PubMed/NCBI

32 

Lengyel Z, Lovig C, Kommedal S, Keszthelyi R, Szekeres G, Battyáni Z, Csernus V and Nagy AD: Altered expression patterns of clock gene mRNAs and clock proteins in human skin tumors. Tumour Biol. 34:811–819. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Zhao N, Yang K, Yang G, Chen D, Tang H, Zhao D and Zhao C: Aberrant expression of clock gene period1 and its correlations with the growth, proliferation and metastasis of buccal squamous cell carcinoma. PLoS One. 8:e558942013. View Article : Google Scholar : PubMed/NCBI

34 

Hsu CM, Lin PM, Lai CC, Lin HC, Lin SF and Yang MY: PER1 and CLOCK: Potential circulating biomarkers for head and neck squamous cell carcinoma. Head Neck. 36:1018–1026. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Cadenas C, van de Sandt L, Edlund K, Lohr M, Hellwig B, Marchan R, Schmidt M, Rahnenführer J, Oster H and Hengstler JG: Loss of circadian clock gene expression is associated with tumor progression in breast cancer. Cell Cycle. 13:3282–3291. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Liu B, Xu K, Jiang Y and Li X: Aberrant expression of Per1, Per2 and Per3 and their prognostic relevance in non-small cell lung cancer. Int J Clin Exp Pathol. 7:7863–7871. 2014.PubMed/NCBI

37 

Larkin JC and Woolford JL Jr: Molecular cloning and analysis of the CRY1 gene: A yeast ribosomal protein gene. Nucleic Acids Res. 11:403–420. 1983. View Article : Google Scholar : PubMed/NCBI

38 

Kume K, Zylka MJ, Sriram S, Shearman LP, Weaver DR, Jin X, Maywood ES, Hastings MH and Reppert SM: mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell. 98:193–205. 1999. View Article : Google Scholar : PubMed/NCBI

39 

Zhou YD, Barnard M, Tian H, Li X, Ring HZ, Francke U, Shelton J, Richardson J, Russell DW and McKnight SL: Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system. Proc Natl Acad Sci USA. 94:713–718. 1997. View Article : Google Scholar : PubMed/NCBI

40 

McNamara P, Seo SB, Rudic RD, Sehgal A, Chakravarti D and FitzGerald GA: Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: A humoral mechanism to reset a peripheral clock. Cell. 105:877–889. 2001. View Article : Google Scholar : PubMed/NCBI

41 

Yuan P, Wang S, Zhou F, Wan S, Yang Y, Huang X, Zhang Z, Zhu Y, Zhang H and Xing J: Functional polymorphisms in the NPAS2 gene are associated with overall survival in transcatheter arterial chemoembolization-treated hepatocellular carcinoma patients. Cancer Sci. 105:825–832. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Xue X, Liu F, Han Y, Li P, Yuan B, Wang X, Chen Y, Kuang Y, Zhi Q and Zhao H: Silencing NPAS2 promotes cell growth and invasion in DLD-1 cells and correlated with poor prognosis of colorectal cancer. Biochem Biophys Res Commun. 450:1058–1062. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Rana S, Shahid A, Ullah H and Mahmood S: Lack of association of the NPAS2 gene Ala394Thr polymorphism (rs2305160:G>A) with risk of chronic lymphocytic leukemia. Asian Pac J Cancer Prev. 15:7169–7174. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Fish KJ, Cegielska A, Getman ME, Landes GM and Virshup DM: Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family. J Biol Chem. 270:14875–14883. 1995. View Article : Google Scholar : PubMed/NCBI

45 

Camacho F, Cilio M, Guo Y, Virshup DM, Patel K, Khorkova O, Styren S, Morse B, Yao Z and Keesler GA: Human casein kinase Idelta phosphorylation of human circadian clock proteins period 1 and 2. FEBS Lett. 489:159–165. 2001. View Article : Google Scholar : PubMed/NCBI

46 

Tsuchiya Y, Akashi M, Matsuda M, Goto K, Miyata Y, Node K and Nishida E: Involvement of the protein kinase CK2 in the regulation of mammalian circadian rhythms. Sci Signal. 2:ra262009. View Article : Google Scholar : PubMed/NCBI

47 

Lee H, Chen R, Lee Y, Yoo S and Lee C: Essential roles of CKIdelta and CKIepsilon in the mammalian circadian clock. Proc Natl Acad Sci USA. 106:21359–21364. 2009. View Article : Google Scholar : PubMed/NCBI

48 

Bonnelye E, Vanacker JM, Desbiens X, Begue A, Stehelin D and Laudet V: Rev-erb beta, a new member of the nuclear receptor superfamily, is expressed in the nervous system during chicken development. Cell Growth Differ. 5:1357–1365. 1994.PubMed/NCBI

49 

Lazar MA, Hodin RA, Darling DS and Chin WW: A novel member of the thyroid/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbA alpha transcriptional unit. Mol Cell Biol. 9:1128–1136. 1989. View Article : Google Scholar : PubMed/NCBI

50 

Crumbley C and Burris TP: Direct regulation of CLOCK expression by REV-ERB. PLoS One. 6:e172902011. View Article : Google Scholar : PubMed/NCBI

51 

Dardente H, Fustin JM and Hazlerigg DG: Transcriptional feedback loops in the ovine circadian clock. Comp Biochem Physiol A Mol Integr Physiol. 153:391–398. 2009. View Article : Google Scholar : PubMed/NCBI

52 

Crumbley C, Wang Y, Kojetin DJ and Burris TP: Characterization of the core mammalian clock component, NPAS2, as a REV-ERBalpha/RORalpha target gene. J Biol Chem. 285:35386–35392. 2010. View Article : Google Scholar : PubMed/NCBI

53 

Takeda Y, Kang HS, Angers M and Jetten AM: Retinoic acid-related orphan receptor gamma directly regulates neuronal PAS domain protein 2 transcription in vivo. Nucleic Acids Res. 39:4769–4782. 2011. View Article : Google Scholar : PubMed/NCBI

54 

Bugge A, Feng D, Everett LJ, Briggs ER, Mullican SE, Wang F, Jager J and Lazar MA: Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic function. Genes Dev. 26:657–667. 2012. View Article : Google Scholar : PubMed/NCBI

55 

Mazzoccoli G, Cai Y, Liu S, Francavilla M, Giuliani F, Piepoli A, Pazienza V, Vinciguerra M, Yamamoto T and Takumi T: REV-ERBα and the clock gene machinery in mouse peripheral tissues: A possible role as a synchronizing hinge. J Biol Regul Homeost Agents. 26:265–276. 2012.PubMed/NCBI

56 

Bhargava A, Herzel H and Ananthasubramaniam B: Mining for novel candidate clock genes in the circadian regulatory network. BMC Syst Biol. 9:782015. View Article : Google Scholar : PubMed/NCBI

57 

Shen M, Kawamoto T, Yan W, Nakamasu K, Tamagami M, Koyano Y, Noshiro M and Kato Y: Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes. Biochem Biophys Res Commun. 236:294–298. 1997. View Article : Google Scholar : PubMed/NCBI

58 

Fujimoto K, Shen M, Noshiro M, Matsubara K, Shingu S, Honda K, Yoshida E, Suardita K, Matsuda Y and Kato Y: Molecular cloning and characterization of DEC2, a new member of basic helix-loop-helix proteins. Biochem Biophys Res Commun. 280:164–171. 2001. View Article : Google Scholar : PubMed/NCBI

59 

Noshiro M, Furukawa M, Honma S, Kawamoto T, Hamada T, Honma K and Kato Y: Tissue-specific disruption of rhythmic expression of Dec1 and Dec2 in clock mutant mice. J Biol Rhythms. 20:404–418. 2005. View Article : Google Scholar : PubMed/NCBI

60 

Wu T, Ni Y, Zhuge F, Sun L, Xu B, Kato H and Fu Z: Significant dissociation of expression patterns of the basic helix-loop-helix transcription factors Dec1 and Dec2 in rat kidney. J Exp Biol. 214:1257–1263. 2011. View Article : Google Scholar : PubMed/NCBI

61 

Honma S, Kawamoto T, Takagi Y, Fujimoto K, Sato F, Noshiro M, Kato Y and Honma K: Dec1 and Dec2 are regulators of the mammalian molecular clock. Nature. 419:841–844. 2002. View Article : Google Scholar : PubMed/NCBI

62 

Li Y, Xie M, Song X, Gragen S, Sachdeva K, Wan Y and Yan B: DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter. J Biol Chem. 278:16899–16907. 2003. View Article : Google Scholar : PubMed/NCBI

63 

Seino H, Wu Y, Morohashi S, Kawamoto T, Fujimoto K, Kato Y, Takai Y and Kijima H: Basic helix-loop-helix transcription factor DEC1 regulates the cisplatin-induced apoptotic pathway of human esophageal cancer cells. Biomed Res. 36:89–96. 2015. View Article : Google Scholar : PubMed/NCBI

64 

Jinhua H, Zhao M, Wei S, Haitao Y, Yuwen W, Lili W, Wei L and Jian Y: Down regulation of differentiated embryo-chondrocyte expressed gene 1 is related to the decrease of osteogenic capacity. Curr Drug Targets. 15:432–441. 2014. View Article : Google Scholar : PubMed/NCBI

65 

You J, Lin L, Liu Q, Zhu T, Xia K and Su T: The correlation between the expression of differentiated embryo-chondrocyte expressed gene l and oral squamous cell carcinoma. Eur J Med Res. 19:212014. View Article : Google Scholar : PubMed/NCBI

66 

Bi H, Li S, Qu X, Wang M, Bai X, Xu Z, Ao X, Jia Z, Jiang X, Yang Y and Wu H: DEC1 regulates breast cancer cell proliferation by stabilizing cyclin E protein and delays the progression of cell cycle S phase. Cell Death Dis. 6:e18912015. View Article : Google Scholar : PubMed/NCBI

67 

Sehgal A, Price JL, Man B and Young MW: Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless. Science. 263:1603–1606. 1994. View Article : Google Scholar : PubMed/NCBI

68 

Mazzoccoli G, Laukkanen MO, Vinciguerra M, Colangelo T and Colantuoni V: A timeless link between circadian patterns and disease. Trends Mol Med. 22:68–81. 2016. View Article : Google Scholar : PubMed/NCBI

69 

Parent MÉ, El-Zein M, Rousseau MC, Pintos J and Siemiatycki J: Night work and the risk of cancer among men. Am J Epidemiol. 176:751–759. 2012. View Article : Google Scholar : PubMed/NCBI

70 

Bhatti P, Cushing-Haugen KL, Wicklund KG, Doherty JA and Rossing MA: Nightshift work and risk of ovarian cancer. Occup Environ Med. 70:231–237. 2013. View Article : Google Scholar : PubMed/NCBI

71 

Ijaz S, Verbeek J, Seidler A, Lindbohm ML, Ojajärvi A, Orsini N, Costa G and Neuvonen K: Night-shift work and breast cancer-a systematic review and meta-analysis. Scand J Work Environ Health. 39:431–447. 2013. View Article : Google Scholar : PubMed/NCBI

72 

Zhao L, Isayama K, Chen H, Yamauchi N, Shigeyoshi Y, Hashimoto S and Hattori MA: The nuclear receptor REV-ERBα represses the transcription of growth/differentiation factor 10 and 15 genes in rat endometrium stromal cells. Physiol Rep. 4:pii:e126632016. View Article : Google Scholar

73 

Canaple L, Kakizawa T and Laudet V: The days and nights of cancer cells. Cancer Res. 63:7545–7552. 2003.PubMed/NCBI

74 

Schibler U: The daily timing of gene expression and physiology in mammals. Dialogues Clin Neurosci. 9:257–272. 2007.PubMed/NCBI

75 

Kornmann B, Schaad O, Bujard H, Takahashi JS and Schibler U: System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock. PLoS Biol. 5:e342007. View Article : Google Scholar : PubMed/NCBI

76 

Walker JR and Hogenesch JB: RNA profiling in circadian biology. Methods Enzymol. 393:366–376. 2005. View Article : Google Scholar : PubMed/NCBI

77 

Storch KF, Lipan O, Leykin I, Viswanathan N, Davis FC, Wong WH and Weitz CJ: Extensive and divergent circadian gene expression in liver and heart. Nature. 417:78–83. 2002. View Article : Google Scholar : PubMed/NCBI

78 

Panda S, Antoch MP, Miller BH, Su AI, Schook AB, Straume M, Schultz PG, Kay SA, Takahashi JS and Hogenesch JB: Coordinated transcription of key pathways in the mouse by the circadian clock. Cell. 109:307–320. 2002. View Article : Google Scholar : PubMed/NCBI

79 

McCarthy JJ, Andrews JL, McDearmon EL, Campbell KS, Barber BK, Miller BH, Walker JR, Hogenesch JB, Takahashi JS and Esser KA: Identification of the circadian transcriptome in adult mouse skeletal muscle. Physiol Genomics. 31:86–95. 2007. View Article : Google Scholar : PubMed/NCBI

80 

Kornmann B, Preitner N, Rifat D, Fleury-Olela F and Schibler U: Analysis of circadian liver gene expression by ADDER, a highly sensitive method for the display of differentially expressed mRNAs. Nucleic Acids Res. 29:E51–E61. 2001. View Article : Google Scholar : PubMed/NCBI

81 

Duffield GE, Best JD, Meurers BH, Bittner A, Loros JJ and Dunlap JC: Circadian programs of transcriptional activation, signaling, and protein turnover revealed by microarray analysis of mammalian cells. Curr Biol. 12:551–557. 2002. View Article : Google Scholar : PubMed/NCBI

82 

Lin YM, Chang JH, Yeh KT, Yang MY, Liu TC, Lin SF, Su WW and Chang JG: Disturbance of circadian gene expression in hepatocellular carcinoma. Mol Carcinog. 47:925–933. 2008. View Article : Google Scholar : PubMed/NCBI

83 

Yang SL, Yu C, Jiang JX, Liu LP, Fang X and Wu C: Hepatitis B virus X protein disrupts the balance of the expression of circadian rhythm genes in hepatocellular carcinoma. Oncol Lett. 8:2715–2720. 2014.PubMed/NCBI

84 

Krugluger W, Brandstaetter A, Kállay E, Schueller J, Krexner E, Kriwanek S, Bonner E and Cross HS: Regulation of genes of the circadian clock in human colon cancer: Reduced period-1 and dihydropyrimidine dehydrogenase transcription correlates in high-grade tumors. Cancer Res. 67:7917–7922. 2007. View Article : Google Scholar : PubMed/NCBI

85 

Wang Y, Hua L, Lu C and Chen Z: Expression of circadian clock gene human Period2 (hPer2) in human colorectal carcinoma. World J Surg Oncol. 9:1662011. View Article : Google Scholar : PubMed/NCBI

86 

Mazzoccoli G, Panza A, Valvano MR, Palumbo O, Carella M, Pazienza V, Biscaglia G, Tavano F, Di Sebastiano P, Andriulli A and Piepoli A: Clock gene expression levels and relationship with clinical and pathological features in colorectal cancer patients. Chronobiol Int. 28:841–851. 2011. View Article : Google Scholar : PubMed/NCBI

87 

Oshima T, Takenoshita S, Akaike M, Kunisaki C, Fujii S, Nozaki A, Numata K, Shiozawa M, Rino Y, Tanaka K, et al: Expression of circadian genes correlates with liver metastasis and outcomes in colorectal cancer. Oncol Rep. 25:1439–1446. 2011. View Article : Google Scholar : PubMed/NCBI

88 

Wang X, Yan D, Teng M, Fan J, Zhou C, Li D, Qiu G, Sun X, Li T, Xing T, et al: Reduced expression of PER3 is associated with incidence and development of colon cancer. Ann Surg Oncol. 19:3081–3088. 2012. View Article : Google Scholar : PubMed/NCBI

89 

Karantanos T, Theodoropoulos G, Gazouli M, Vaiopoulou A, Karantanou C, Lymberi M and Pektasides D: Expression of clock genes in patients with colorectal cancer. Int J Biol Markers. 28:280–285. 2013. View Article : Google Scholar : PubMed/NCBI

90 

Wang L, Chen B, Wang Y, Sun N, Lu C, Qian R and Hua L: hClock gene expression in human colorectal carcinoma. Mol Med Rep. 8:1017–1022. 2013. View Article : Google Scholar : PubMed/NCBI

91 

Yu H, Meng X, Wu J, Pan C, Ying X, Zhou Y, Liu R and Huang W: Cryptochrome 1 overexpression correlates with tumor progression and poor prognosis in patients with colorectal cancer. PLoS One. 8:e616792013. View Article : Google Scholar : PubMed/NCBI

92 

Wang Y, Xing T, Huang L, Song G, Sun X, Zhong L, Fan J, Yan D, Zhou C, Cui F, et al: Period 1 and estrogen receptor-beta are downregulated in Chinese colon cancers. Int J Clin Exp Pathol. 8:8178–8188. 2015.PubMed/NCBI

93 

Zhao H, Zeng ZL, Yang J, Jin Y, Qiu MZ, Hu XY, Han J, Liu KY, Liao JW, Xu RH and Zou QF: Prognostic relevance of period1 (Per1) and period2 (Per2) expression in human gastric cancer. Int J Clin Exp Pathol. 7:619–630. 2014.PubMed/NCBI

94 

Hu ML, Yeh KT, Lin PM, Hsu CM, Hsiao HH, Liu YC, Lin HY, Lin SF and Yang MY: Deregulated expression of circadian clock genes in gastric cancer. BMC Gastroenterol. 14:672014. View Article : Google Scholar : PubMed/NCBI

95 

Relles D, Sendecki J, Chipitsyna G, Hyslop T, Yeo CJ and Arafat HA: Circadian gene expression and clinicopathologic correlates in pancreatic cancer. J Gastrointest Surg. 17:443–450. 2013. View Article : Google Scholar : PubMed/NCBI

96 

Yu C, Yang SL, Fang X, Jiang JX, Sun CY and Huang T: Hypoxia disrupts the expression levels of circadian rhythm genes in hepatocellular carcinoma. Mol Med Rep. 11:4002–4008. 2015. View Article : Google Scholar : PubMed/NCBI

97 

Benegiamo G, Mazzoccoli G, Cappello F, Rappa F, Scibetta N, Oben J, Greco A, Williams R, Andriulli A, Vinciguerra M and Pazienza V: Mutual antagonism between circadian protein period 2 and hepatitis C virus replication in hepatocytes. PLoS One. 8:e605272013. View Article : Google Scholar : PubMed/NCBI

98 

Kondratov R: Circadian clock and cancer therapy: An unexpected journey. Ann Med. 46:189–190. 2014. View Article : Google Scholar : PubMed/NCBI

99 

Innominato PF, Roche VP, Palesh OG, Ulusakarya A, Spiegel D and Lévi FA: The circadian timing system in clinical oncology. Ann Med. 46:191–207. 2014. View Article : Google Scholar : PubMed/NCBI

100 

Akgun Z, Saglam S, Yucel S, Gural Z, Balik E, Cipe G, Yildiz S, Kilickap S, Okyar A and Kaytan-Saglam E: Neoadjuvant chronomodulated capecitabine with radiotherapy in rectal cancer: A phase II brunch regimen study. Cancer Chemother Pharmacol. 74:751–756. 2014. View Article : Google Scholar : PubMed/NCBI

101 

Zarogoulidis P, Darwiche K, Huang H, Spyratos D, Yarmus L, Li Q, Kakolyris S, Syrigos K and Zarogoulidis K: Time recall; future concept of chronomodulating chemotherapy for cancer. Curr Pharm Biotechnol. 14:632–642. 2013. View Article : Google Scholar : PubMed/NCBI

102 

Chen D, Cheng J, Yang K, Ma Y and Yang F: Retrospective analysis of chronomodulated chemotherapy versus conventional chemotherapy with paclitaxel, carboplatin, and 5-fluorouracil in patients with recurrent and/or metastatic head and neck squamous cell carcinoma. Onco Targets Ther. 6:1507–1514. 2013.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yang SL, Ren QG, Wen L, Hu JL and Wang HY: Research progress on circadian clock genes in common abdominal malignant tumors (Review). Oncol Lett 14: 5091-5098, 2017.
APA
Yang, S., Ren, Q., Wen, L., Hu, J., & Wang, H. (2017). Research progress on circadian clock genes in common abdominal malignant tumors (Review). Oncology Letters, 14, 5091-5098. https://doi.org/10.3892/ol.2017.6856
MLA
Yang, S., Ren, Q., Wen, L., Hu, J., Wang, H."Research progress on circadian clock genes in common abdominal malignant tumors (Review)". Oncology Letters 14.5 (2017): 5091-5098.
Chicago
Yang, S., Ren, Q., Wen, L., Hu, J., Wang, H."Research progress on circadian clock genes in common abdominal malignant tumors (Review)". Oncology Letters 14, no. 5 (2017): 5091-5098. https://doi.org/10.3892/ol.2017.6856
Copy and paste a formatted citation
x
Spandidos Publications style
Yang SL, Ren QG, Wen L, Hu JL and Wang HY: Research progress on circadian clock genes in common abdominal malignant tumors (Review). Oncol Lett 14: 5091-5098, 2017.
APA
Yang, S., Ren, Q., Wen, L., Hu, J., & Wang, H. (2017). Research progress on circadian clock genes in common abdominal malignant tumors (Review). Oncology Letters, 14, 5091-5098. https://doi.org/10.3892/ol.2017.6856
MLA
Yang, S., Ren, Q., Wen, L., Hu, J., Wang, H."Research progress on circadian clock genes in common abdominal malignant tumors (Review)". Oncology Letters 14.5 (2017): 5091-5098.
Chicago
Yang, S., Ren, Q., Wen, L., Hu, J., Wang, H."Research progress on circadian clock genes in common abdominal malignant tumors (Review)". Oncology Letters 14, no. 5 (2017): 5091-5098. https://doi.org/10.3892/ol.2017.6856
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team