Open Access

Co‑activation of Hedgehog and Wnt signaling pathways is associated with poor outcomes in triple negative breast cancer

  • Authors:
    • Kimberly M. Arnold
    • Ryan T. Pohlig
    • Jennifer Sims‑Mourtada
  • View Affiliations

  • Published online on: September 1, 2017     https://doi.org/10.3892/ol.2017.6874
  • Pages: 5285-5292
  • Copyright: © Arnold et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Hedgehog (HH) and Wnt pathway activation have been implicated in poor prognosis of breast cancer. Crosstalk between these two pathways has been demonstrated to be important in breast cancer progression, however the association between these two pathways and breast cancer survival rate is unknown. The present study comprised a cohort of 36 patients with triple negative breast cancer (TNBC) to investigate co‑activation of HH and canonical Wnt pathway in association to patient outcome. All patients had varying degrees of cytoplasmic sonic HH and glioma‑associated oncogene homolog (Gli)‑1 staining, which positively correlated with tumor stage. Nuclear β‑catenin was additionally correlated to tumor stage. A significant association was observed between nuclear Gli‑1 and nuclear β‑catenin. Co‑activation of HH and Wnt pathways was associated with poorer prognosis in TNBC patients resulting in a greater risk of early recurrence and decreased overall survival rate compared with patients with only one pathway activated. Therefore, the combined activation status of the HH and Wnt pathways may be a useful prognostic marker for TNBC patients at risk for early recurrence.
View Figures
View References

Related Articles

Journal Cover

November-2017
Volume 14 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Arnold KM, Pohlig RT and Sims‑Mourtada J: Co‑activation of Hedgehog and Wnt signaling pathways is associated with poor outcomes in triple negative breast cancer. Oncol Lett 14: 5285-5292, 2017
APA
Arnold, K.M., Pohlig, R.T., & Sims‑Mourtada, J. (2017). Co‑activation of Hedgehog and Wnt signaling pathways is associated with poor outcomes in triple negative breast cancer. Oncology Letters, 14, 5285-5292. https://doi.org/10.3892/ol.2017.6874
MLA
Arnold, K. M., Pohlig, R. T., Sims‑Mourtada, J."Co‑activation of Hedgehog and Wnt signaling pathways is associated with poor outcomes in triple negative breast cancer". Oncology Letters 14.5 (2017): 5285-5292.
Chicago
Arnold, K. M., Pohlig, R. T., Sims‑Mourtada, J."Co‑activation of Hedgehog and Wnt signaling pathways is associated with poor outcomes in triple negative breast cancer". Oncology Letters 14, no. 5 (2017): 5285-5292. https://doi.org/10.3892/ol.2017.6874