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Co‑activation of Hedgehog and Wnt signaling pathways is associated with poor outcomes in triple negative breast cancer

  • Authors:
    • Kimberly M. Arnold
    • Ryan T. Pohlig
    • Jennifer Sims‑Mourtada
  • View Affiliations / Copyright

    Affiliations: Center for Translational Cancer Research, Helen F. Graham Cancer Center, Newark, DE 19713, USA
    Copyright: © Arnold et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5285-5292
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    Published online on: September 1, 2017
       https://doi.org/10.3892/ol.2017.6874
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Abstract

Hedgehog (HH) and Wnt pathway activation have been implicated in poor prognosis of breast cancer. Crosstalk between these two pathways has been demonstrated to be important in breast cancer progression, however the association between these two pathways and breast cancer survival rate is unknown. The present study comprised a cohort of 36 patients with triple negative breast cancer (TNBC) to investigate co‑activation of HH and canonical Wnt pathway in association to patient outcome. All patients had varying degrees of cytoplasmic sonic HH and glioma‑associated oncogene homolog (Gli)‑1 staining, which positively correlated with tumor stage. Nuclear β‑catenin was additionally correlated to tumor stage. A significant association was observed between nuclear Gli‑1 and nuclear β‑catenin. Co‑activation of HH and Wnt pathways was associated with poorer prognosis in TNBC patients resulting in a greater risk of early recurrence and decreased overall survival rate compared with patients with only one pathway activated. Therefore, the combined activation status of the HH and Wnt pathways may be a useful prognostic marker for TNBC patients at risk for early recurrence.
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Copy and paste a formatted citation
Spandidos Publications style
Arnold KM, Pohlig RT and Sims‑Mourtada J: Co‑activation of Hedgehog and Wnt signaling pathways is associated with poor outcomes in triple negative breast cancer. Oncol Lett 14: 5285-5292, 2017.
APA
Arnold, K.M., Pohlig, R.T., & Sims‑Mourtada, J. (2017). Co‑activation of Hedgehog and Wnt signaling pathways is associated with poor outcomes in triple negative breast cancer. Oncology Letters, 14, 5285-5292. https://doi.org/10.3892/ol.2017.6874
MLA
Arnold, K. M., Pohlig, R. T., Sims‑Mourtada, J."Co‑activation of Hedgehog and Wnt signaling pathways is associated with poor outcomes in triple negative breast cancer". Oncology Letters 14.5 (2017): 5285-5292.
Chicago
Arnold, K. M., Pohlig, R. T., Sims‑Mourtada, J."Co‑activation of Hedgehog and Wnt signaling pathways is associated with poor outcomes in triple negative breast cancer". Oncology Letters 14, no. 5 (2017): 5285-5292. https://doi.org/10.3892/ol.2017.6874
Copy and paste a formatted citation
x
Spandidos Publications style
Arnold KM, Pohlig RT and Sims‑Mourtada J: Co‑activation of Hedgehog and Wnt signaling pathways is associated with poor outcomes in triple negative breast cancer. Oncol Lett 14: 5285-5292, 2017.
APA
Arnold, K.M., Pohlig, R.T., & Sims‑Mourtada, J. (2017). Co‑activation of Hedgehog and Wnt signaling pathways is associated with poor outcomes in triple negative breast cancer. Oncology Letters, 14, 5285-5292. https://doi.org/10.3892/ol.2017.6874
MLA
Arnold, K. M., Pohlig, R. T., Sims‑Mourtada, J."Co‑activation of Hedgehog and Wnt signaling pathways is associated with poor outcomes in triple negative breast cancer". Oncology Letters 14.5 (2017): 5285-5292.
Chicago
Arnold, K. M., Pohlig, R. T., Sims‑Mourtada, J."Co‑activation of Hedgehog and Wnt signaling pathways is associated with poor outcomes in triple negative breast cancer". Oncology Letters 14, no. 5 (2017): 5285-5292. https://doi.org/10.3892/ol.2017.6874
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