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The prognostic significance of tumor lymphangiogenesis and lymphatic vessel density in endometrioid carcinoma of the uterine corpus

  • Authors:
    • Mika Sakaki
    • Masanori Yasuda
    • Mitsutake Yano
    • Yoshiya Goto
    • Masaru Nakamura
    • Hidekazu Kayano
    • Kosei Hasegawa
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Saitama Medical University International Medical Center, Hidaka, Saitama 350‑1298, Japan, Faculty of Health Sciences, Saitama Medical University, Hidaka, Saitama 350‑1298, Japan, Department of Gynecologic Oncology, Saitama Medical University International Medical Center, Hidaka, Saitama 350‑1298, Japan
    Copyright: © Sakaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5313-5318
    |
    Published online on: September 4, 2017
       https://doi.org/10.3892/ol.2017.6885
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Abstract

The present study aimed to assess the prognostic significance of tumor lymphangiogenesis and lymphatic vessel density (LVD) in endometrioid carcinoma of the uterine corpus. The association between LVD and various factors, including lymphatic vessel invasion (LVI), and nodal metastases, were investigated. Among 202 surgically treated cases, 19 cases with nodal metastases with the infiltration reaching the outer‑half myometrium (N+ group) were selected. The LVDs of hotspots in each case were examined at 100x magnification on D2‑40 stained slides of the inner‑ and outer‑half myometrium of the peritumoral, and control compartments. Furthermore, for the peritumoral compartment, the LVDs in two types of areas, LVI‑present and LVI‑absent, were examined for each location of myometrium, which amounted to 6 spots/case. They were statistically compared. Second, to determine whether the existing myometrium influenced LVD, LVDs in the intratumoral compartment were investigated, which were defined as a region where residual muscular tissue was unrecognizable with desmin‑immnostaining. As a negative control group, LVDs of the inner‑ and outer‑half myometrium of the peritumoral, and control compartments of 29 cases without nodal metastases in stage IB (N‑ group) were examined. No significant association was identified between the LVD and frequency of LVI. However, the LVDs in the peritumoral compartment and inner‑half myometrium were higher compared those in the control compartment, and outer‑half myometrium in N+ and N‑ groups, respectively. No significant differences were identified in LVD of the peritumoral compartment between groups. The lymphatic vessels were absent where the existing muscular tissue was absent in 16/19 cases. Although higher LVDs in the peritumoral compartment suggested tumor lymphangiogenesis, it was not associated with LVI and nodal metastases. Other factors that influenced LVD were the location in the myometrium and the existing myometrium.
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Copy and paste a formatted citation
Spandidos Publications style
Sakaki M, Yasuda M, Yano M, Goto Y, Nakamura M, Kayano H and Hasegawa K: The prognostic significance of tumor lymphangiogenesis and lymphatic vessel density in endometrioid carcinoma of the uterine corpus. Oncol Lett 14: 5313-5318, 2017.
APA
Sakaki, M., Yasuda, M., Yano, M., Goto, Y., Nakamura, M., Kayano, H., & Hasegawa, K. (2017). The prognostic significance of tumor lymphangiogenesis and lymphatic vessel density in endometrioid carcinoma of the uterine corpus. Oncology Letters, 14, 5313-5318. https://doi.org/10.3892/ol.2017.6885
MLA
Sakaki, M., Yasuda, M., Yano, M., Goto, Y., Nakamura, M., Kayano, H., Hasegawa, K."The prognostic significance of tumor lymphangiogenesis and lymphatic vessel density in endometrioid carcinoma of the uterine corpus". Oncology Letters 14.5 (2017): 5313-5318.
Chicago
Sakaki, M., Yasuda, M., Yano, M., Goto, Y., Nakamura, M., Kayano, H., Hasegawa, K."The prognostic significance of tumor lymphangiogenesis and lymphatic vessel density in endometrioid carcinoma of the uterine corpus". Oncology Letters 14, no. 5 (2017): 5313-5318. https://doi.org/10.3892/ol.2017.6885
Copy and paste a formatted citation
x
Spandidos Publications style
Sakaki M, Yasuda M, Yano M, Goto Y, Nakamura M, Kayano H and Hasegawa K: The prognostic significance of tumor lymphangiogenesis and lymphatic vessel density in endometrioid carcinoma of the uterine corpus. Oncol Lett 14: 5313-5318, 2017.
APA
Sakaki, M., Yasuda, M., Yano, M., Goto, Y., Nakamura, M., Kayano, H., & Hasegawa, K. (2017). The prognostic significance of tumor lymphangiogenesis and lymphatic vessel density in endometrioid carcinoma of the uterine corpus. Oncology Letters, 14, 5313-5318. https://doi.org/10.3892/ol.2017.6885
MLA
Sakaki, M., Yasuda, M., Yano, M., Goto, Y., Nakamura, M., Kayano, H., Hasegawa, K."The prognostic significance of tumor lymphangiogenesis and lymphatic vessel density in endometrioid carcinoma of the uterine corpus". Oncology Letters 14.5 (2017): 5313-5318.
Chicago
Sakaki, M., Yasuda, M., Yano, M., Goto, Y., Nakamura, M., Kayano, H., Hasegawa, K."The prognostic significance of tumor lymphangiogenesis and lymphatic vessel density in endometrioid carcinoma of the uterine corpus". Oncology Letters 14, no. 5 (2017): 5313-5318. https://doi.org/10.3892/ol.2017.6885
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