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Correlation of MMP-9 and p53 protein expression with prognosis in metastatic spinal tumor of lung cancer

  • Authors:
    • Shuquan Zhang
    • Minfei Wu
    • Yi Zhao
    • Rui Gu
    • Chuangang Peng
    • Jiabei Liu
    • Qingsan Zhu
    • Ye Li
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Tianjin Nankai Hospital, Tianjin 300100, P.R. China, Department of Orthopedics, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China, Department of Surgery, Peking Union Medical College Hospital, Beijing 100032, P.R. China, Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5452-5456
    |
    Published online on: September 5, 2017
       https://doi.org/10.3892/ol.2017.6887
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Abstract

The aim of the study was to compare the protein expression of MMP-9 and p53 and examine their correlation with prognosis in lung cancer metastatic spinal tumor. Tissue samples were obtained from 30 cases of para-cancerous tissue (group I), 75 cases of non-metastatic lung cancer tissue (group II) and 100 cases of metastatic spinal tumor tissue of lung cancer (group III). The protein expression of MMP-9 and p53 was detected by immunohistochemistry and was present in all three groups. The positive rate for MMP-9 was 20, 67 and 83%, respectively. There was a significant difference among the three groups (p<0.05). The positive rate for p53 was 16.7, 78.7 and 92%, respectively. There was a highly significant difference among the three groups (p<0.01). There was a positive correlation between the protein expressions of MMP-9 and p53 (Spearman's correlation coefficient r=0.351, p<0.05). The positive or negative expression of the two proteins was statistically significant (p<0.05) for 5-year survival. The expression of MMP-9 and p53 proteins in metastatic spinal tumors of lung cancer showed increasing trends, and the expression of MMP-9 and p53 proteins was significantly higher compared to non-metastatic lung cancer tissue and para-cancerous tissue samples. This likely was associated with the invasion and metastasis of lung cancer to the spine. Survival analysis suggested that the overexpression of p53 and MMP-9 were correlated with poor prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang S, Wu M, Zhao Y, Gu R, Peng C, Liu J, Zhu Q and Li Y: Correlation of MMP-9 and p53 protein expression with prognosis in metastatic spinal tumor of lung cancer. Oncol Lett 14: 5452-5456, 2017.
APA
Zhang, S., Wu, M., Zhao, Y., Gu, R., Peng, C., Liu, J. ... Li, Y. (2017). Correlation of MMP-9 and p53 protein expression with prognosis in metastatic spinal tumor of lung cancer. Oncology Letters, 14, 5452-5456. https://doi.org/10.3892/ol.2017.6887
MLA
Zhang, S., Wu, M., Zhao, Y., Gu, R., Peng, C., Liu, J., Zhu, Q., Li, Y."Correlation of MMP-9 and p53 protein expression with prognosis in metastatic spinal tumor of lung cancer". Oncology Letters 14.5 (2017): 5452-5456.
Chicago
Zhang, S., Wu, M., Zhao, Y., Gu, R., Peng, C., Liu, J., Zhu, Q., Li, Y."Correlation of MMP-9 and p53 protein expression with prognosis in metastatic spinal tumor of lung cancer". Oncology Letters 14, no. 5 (2017): 5452-5456. https://doi.org/10.3892/ol.2017.6887
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang S, Wu M, Zhao Y, Gu R, Peng C, Liu J, Zhu Q and Li Y: Correlation of MMP-9 and p53 protein expression with prognosis in metastatic spinal tumor of lung cancer. Oncol Lett 14: 5452-5456, 2017.
APA
Zhang, S., Wu, M., Zhao, Y., Gu, R., Peng, C., Liu, J. ... Li, Y. (2017). Correlation of MMP-9 and p53 protein expression with prognosis in metastatic spinal tumor of lung cancer. Oncology Letters, 14, 5452-5456. https://doi.org/10.3892/ol.2017.6887
MLA
Zhang, S., Wu, M., Zhao, Y., Gu, R., Peng, C., Liu, J., Zhu, Q., Li, Y."Correlation of MMP-9 and p53 protein expression with prognosis in metastatic spinal tumor of lung cancer". Oncology Letters 14.5 (2017): 5452-5456.
Chicago
Zhang, S., Wu, M., Zhao, Y., Gu, R., Peng, C., Liu, J., Zhu, Q., Li, Y."Correlation of MMP-9 and p53 protein expression with prognosis in metastatic spinal tumor of lung cancer". Oncology Letters 14, no. 5 (2017): 5452-5456. https://doi.org/10.3892/ol.2017.6887
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