Open Access

Brain metastatic alveolar soft‑part sarcoma: Clinicopathological profiles, management and outcomes

  • Authors:
    • Xiaogang Tao
    • Zonggang Hou
    • Zhen Wu
    • Shuyu Hao
    • Baiyun Liu
  • View Affiliations

  • Published online on: September 14, 2017     https://doi.org/10.3892/ol.2017.6941
  • Pages: 5779-5784
  • Copyright: © Tao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Alveolar soft‑part sarcoma (ASPS) is a rare sarcoma that presents in the buttocks or thigh of young adults and often metastasizes to the brain. The present study examined the clinical features and morphology of brain metastatic ASPS. The case records of eight patients with brain metastatic ASPS admitted between November 2008 and March 2015 were reviewed. The relevant clinical data (including patient age and sex, neuroimaging studies, histopathological and immunohistochemical features, surgical records and follow‑up reports) were collected through a review of patient records. The sex distribution was 3:1 male to female and the age ranged between 15 and 33 years at the time of surgery. In total, five patients with brain metastases had concurrent pulmonary metastases. The lesions were hypointense on T1‑weighted images in every patient, hyperintense on T2‑weighted images in six patients and contrast enhancement was present in all patients. The most notable immunohistochemical feature was strong immunohistochemical staining for TFE3 in each patient. Gross total resection was performed in all eight patients, with two patients undergoing adjuvant radiotherapy and one undergoing adjuvant chemotherapy. Four recurrent cases were observed during the follow‑up. TFE3 staining and knowledge of its microscopic characteristics would facilitate earlier diagnosis: Early diagnosis with a multidisciplinary, multimodal approach to treatment is required to achieve extended disease‑free survival in patients with brain metastatic ASPS.
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November-2017
Volume 14 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Tao X, Hou Z, Wu Z, Hao S and Liu B: Brain metastatic alveolar soft‑part sarcoma: Clinicopathological profiles, management and outcomes. Oncol Lett 14: 5779-5784, 2017
APA
Tao, X., Hou, Z., Wu, Z., Hao, S., & Liu, B. (2017). Brain metastatic alveolar soft‑part sarcoma: Clinicopathological profiles, management and outcomes. Oncology Letters, 14, 5779-5784. https://doi.org/10.3892/ol.2017.6941
MLA
Tao, X., Hou, Z., Wu, Z., Hao, S., Liu, B."Brain metastatic alveolar soft‑part sarcoma: Clinicopathological profiles, management and outcomes". Oncology Letters 14.5 (2017): 5779-5784.
Chicago
Tao, X., Hou, Z., Wu, Z., Hao, S., Liu, B."Brain metastatic alveolar soft‑part sarcoma: Clinicopathological profiles, management and outcomes". Oncology Letters 14, no. 5 (2017): 5779-5784. https://doi.org/10.3892/ol.2017.6941